Comprehensive therapy of pancreatic cancer by integrative traditional and western medicine

Background and Aims: Pancreatic cancer has the lowest survival rate of all cancers (4%), and it accounts for 1.9% of new cancer cases in Hong Kong. Combined treatment with Chinese herbal medicine (CHM) and Western medicine has yielded promising results, leading to improved prognosis and overall survival. This retrospective case series aimed to illustrate the improved survival and quality of life outcomes of pancreatic cancer patients administered CHM based on traditional Chinese medicine theory. Methods: To investigate the effectiveness of CHM in prolonging overall survival, 182 patients diagnosed with pancreatic cancer who received CHM treatment were observed from 2005 to 2015. Results: One hundred eighty-two pancreatic cancer patients were treated with CHM; 21 patients died. The mean and median survival of these patients were 29.6 and 15.2 months, respectively; the 1-year survival rate was 76% (range = 4 months to 9 years). These results are better than those reported in patients treated with Western medicine, suggesting the need for further study of CHM. Conclusion: A superior clinical outcome may be obtained with CHM treatment. The case series illustrates the potential benefits and safety issues of CHM in pancreatic cancer patients that could be relevant for developing strategies to increase individualization of pancreatic cancer treatment and improve survival. This study may facilitate interprofessional communication and improved clinical management of pancreatic cancer patients.

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Clinical observation on the different frequency hearing damages in sudden deafness treated by electroacupuncture combined with western medicine comprehensive therapy

World Journal of Acupuncture - Moxibustion ◽

10.1016/s1003-5257(12)60023-3 ◽

2012 ◽

Vol 22 (2) ◽

pp. 22-27 ◽

Cited By ~ 2

Author(s):

Ling QIU ◽

Xu ZHENG ◽

Fang XIE ◽

Min ZHANG ◽

Ji ZHANG ◽

...

Keyword(s):

Western Medicine ◽

Clinical Observation ◽

Sudden Deafness ◽

Comprehensive Therapy

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Survival Benefit of Metformin Adjuvant Treatment For Pancreatic Cancer Patients: a Systematic Review and Meta-Analysis

Cellular Physiology and Biochemistry ◽

10.1159/000493214 ◽

2018 ◽

Vol 49 (3) ◽

pp. 837-847 ◽

Cited By ~ 12

Author(s):

Guoxing Wan ◽

Xue Sun ◽

Fang Li ◽

Xuanbin Wang ◽

Chen Li ◽

...

Keyword(s):

Pancreatic Cancer ◽

Cancer Patients ◽

Adjuvant Treatment ◽

Survival Benefit ◽

Meta Analysis ◽

Clinical Stage ◽

Stage I ◽

Metformin Therapy ◽

Risk Of Death ◽

Comprehensive Therapy

Background/Aims: Previous studies on the effect of metformin therapy on survival of pancreatic cancer patients obtained inconsistent findings. To reevaluate the prognostic value of metformin adjuvant treatment, a meta-analysis was carried out. Methods: Relevant articles addressing the association between metformin use and pancreatic cancer survival were electronically searched to identify eligible studies. Pooled hazard ratios (HRs) and 95% confidence intervals (95% CIs) were calculated to assess the strength of the association. Results: Totally, seventeen studies involving 36791 participants were included. Overall, metformin use was found to be significantly associated with a favorable OS (HR=0.88, 95% CI=0.80-0.97). Subgroup analyses by ethnicity showed a significantly reduced risk of death for metformin users compared with non-users in Asians (HR=0.74, 95% CI=0.58-0.94) but nonsignificant in Caucasians. When stratified by clinical stage, a remarkable reduction of mortality risk in patients at stage I-II treated with metformin (HR=0.76, 95% CI=0.68-0.86) was found as well as the group at stage I-IV (HR=0.88, 95% CI=0.79-0.99), but not in patients at stage III-IV. In the stratification analyses based on treatment strategy, metformin therapy was found to be associated with a better clinical outcome in patients receiving surgery or comprehensive therapy (HR=0.73, 95% CI=0.62-0.87; HR=0.88, 95% CI=0.79-0.97) but not chemotherapy. However, the overall analysis failed to show a significant association between metformin use and DFS (HR=1.54, 95% CI=0.94 -2.50) with only 2 studies enrolled. Conclusion: The current study has evidenced a significant association of metformin adjuvant treatment with the survival benefit for pancreatic cancer patients, suggesting a potentially available option for the treatment. Further investigation is needed.

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Study on the treatment of pancreatic cancer with integrated traditional Chinese and Western medicine

Medicine ◽

10.1097/md.0000000000017975 ◽

2019 ◽

Vol 98 (47) ◽

pp. e17975 ◽

Cited By ~ 1

Author(s):

Juling Jiang ◽

Rui Liu ◽

Zhenhua Zhang ◽

Xiwen Zhang ◽

Runzhi Qi ◽

...

Keyword(s):

Pancreatic Cancer ◽

Western Medicine

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Therapeutic evaluation on advanced pancreatic cancer Treated by Integrative Chinese and western medicine — Clinical analysis of 56 cases

Chinese Journal of Integrative Medicine ◽

10.1007/bf02836354 ◽

2003 ◽

Vol 9 (1) ◽

pp. 39-43 ◽

Cited By ~ 6

Author(s):

Liu Lu-ming ◽

Wu Liang-cun ◽

Lin Sheng-you ◽

Yang Wei-hong ◽

Guo Yong ◽

...

Keyword(s):

Pancreatic Cancer ◽

Western Medicine ◽

Advanced Pancreatic Cancer ◽

Clinical Analysis ◽

Therapeutic Evaluation

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Integrative therapy for advanced pancreatic cancer using Kampo and western medicine: A case report

EXPLORE ◽

10.1016/j.explore.2020.07.003 ◽

2020 ◽

Author(s):

Masayuki Shimizu ◽

Shin Takayama ◽

Akiko Kikuchi ◽

Ryutaro Arita ◽

Rie Ono ◽

...

Keyword(s):

Pancreatic Cancer ◽

Case Report ◽

Western Medicine ◽

Advanced Pancreatic Cancer ◽

Integrative Therapy

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Effectiveness of Comprehensive Traditional Chinese Therapy in Treating Granulomatous Lobular Mastitis: a Systematic Review and a Meta-analysis

10.21203/rs.3.rs-136205/v1 ◽

2020 ◽

Author(s):

Hongyi Liang ◽

Hanhan Chen ◽

Guangxi Shi ◽

Xiaofei Liu ◽

Jingwei Li

Keyword(s):

Chinese Medicine ◽

Traditional Chinese Medicine ◽

Recurrence Rate ◽

Western Medicine ◽

Statistical Difference ◽

Effective Rate ◽

Maximum Diameter ◽

Cochrane Library ◽

Comprehensive Therapy ◽

Significant Difference

Abstract Background: With the development of Traditional Chinese Medicine (TCM), comprehensive traditional Chinese therapy is often used to treat Granulomatous Lobular Mastitis (GLM), but the effectiveness and risk are still controversial. This study is aimed to evaluate the efficacy of comprehensive therapy of traditional Chinese medicine on GLM.Methods: Articles in both international databases (PubMed, EMBASE, Cochrane Library, Web of Science and Clinicaltrials.gov) and Chinese databases (Chinese National Knowledge Internet (CNKI), Chinese Biomedical Databases (CBM), VIP Chinese periodical service platform and Wan Fang Digital Journals)) were searched. Original studies which reported the effective rate and/or recurrence rate and/or maximum diameter of the mass of comprehensive traditional Chinese therapy were included. The 95% confidence interval (95% CI) for effective rate, recurrence rate and maximum diameter of the mass were calculated and analyzed by review manager 5.3.Results: Eight eligible trials with 309 cases and 265 controls were included, six in Chinese and two in English. Statistical analysis suggested a statistical difference in effective rate (RR = 0.86, 95% CI [0.74, 1.00], P = 0.047) between comprehensive traditional Chinese therapy group and control. Meanwhile, there was statistical difference found in recurrence rate between comprehensive traditional Chinese therapy and western medicine therapy (RR = 3.09, 95% CI [1.50, 6.40], P = 0.002). Besides, no statistical difference existed in maximum diameter of the mass between the two therapies (RR = -5.25, 95% CI [-125.42, 114.93], P = 0.93).Conclusion: Although there was no significant difference in the reduction of breast mass size between comprehensive traditional Chinese therapy and western medicine alone, comprehensive traditional Chinese therapy demonstrated the efficacy in improving the effective rate and reducing the recurrence rate. For GLM patients, comprehensive traditional Chinese therapy could be a potential option.

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