Changes in oxygen consumption of isolated heart muscle from animals treated with cardio-active drugs

1985 ◽  
Vol 5 (1) ◽  
pp. 20-22
Author(s):  
Liu Gui-de ◽  
Yu Wan-li ◽  
Wang Cong-ming
Keyword(s):  
Oxygen Consumption ◽  
Heart Muscle ◽  
Isolated Heart

Some factors influencing O2 consumption of isolated heart muscle

1960 ◽  
Vol 198 (6) ◽  
pp. 1153-1156 ◽  
Author(s):  
William J. Whalen
Keyword(s):  
Oxygen Consumption ◽  
Heart Muscle ◽  
Isolated Heart ◽  
O2 Consumption ◽  
Starling’S Law ◽  
Factors Influencing ◽  
Mammalian Myocardium ◽  
Per Se ◽  
Relationship Of

Oxygen consumption and resting and developed tension in isolated strips of mammalian myocardium were simultaneously measured in specially constructed chambers. In a resting preparation the O2 consumption increased significantly as the length of the muscle was increased. The evidence suggests that the augmented Qo2 (µl/mg dry wt/hr.) is largely a result of the lengthening, per se, and is not due to the maintenance of tension. In the beating preparation, variations in rate and length accounted for most of the change in the O2 uptake, tension being a less significant factor. The possible relationship of these findings to ‘Starling's law of the heart’ is discussed.

scholarly journals Oxygen Consumption of the Isolated Heart of Octopus: Effects of Power Output and Hypoxia

1987 ◽  
Vol 131 (1) ◽  
pp. 137-157
Author(s):  
D. F. HOULIHAN ◽  
C. AGNISOLA ◽  
N. M. HAMILTON ◽  
I. TRARA GENOINO
Keyword(s):  
Oxygen Consumption ◽  
Output Power ◽  
Power Output ◽  
Isolated Heart ◽  
Back Pressure ◽  
Octopus Vulgaris ◽  
Total Oxygen ◽  
Coronary Veins ◽  
Output Flow

A technique is described which allowed the measurement of the oxygen consumption of the isolated heart of Octopus vulgaris. Contraction of the heart resulted in an aortic output and a flow through the heart muscle into coronary veins (the coronary output). The flow and oxygen content of the aortic output and the coronary output were measured with variable input pressures and constant output back pressure (volume loaded), variable output back pressure and constant aortic output (pressure loaded), and during hypoxia. Volume loading of the heart resulted in an increase in aortic output, power output and total oxygen consumption. Pressure loading increased power output and total oxygen consumption of the heart. Exposure to hypoxia decreased the aortic output, power output and total cardiac oxygen consumption. In the response of the heart to reduced work, brought about either by a reduced input pressure or by hypoxic perfusate, the power output was linearly related to the total oxygen consumption of the heart. The oxygen extracted from the coronary output accounted for 80–100% of the total oxygen consumption of the heart. Coronary output amounted to 30% of the total cardiac output at maximum power output. In volume-loaded hearts the volume of the coronary output increased as aortic output increased; in pressure-loaded hearts coronary output increased as power output increased, but aortic output remained constant. In hypoxia, the coronary output increased as the aortic output fell. At a perfusate Po2 of around 50 Torr (1 Torr = 133 Pa), the aortic output ceased although the heart continued to beat and the coronary output continued, accounting for all of the oxygen consumption of the heart. The coronary output flow in vitro therefore has the capacity to be varied independently of the aortic output flow to maintain the oxygen supply to the perfused cardiac muscle.

Excitability and Refractory Period of Isolated Heart Muscle of the Cat

1951 ◽  
Vol 164 (3) ◽  
pp. 589-600 ◽  
Author(s):  
Joseph R. DiPalma ◽  
Antonio V. Mascatello
Keyword(s):  
Heart Muscle ◽  
Refractory Period ◽  
Isolated Heart

Determinants of hypoxic contracture in isolated heart muscle preparations

1979 ◽  
Vol 13 (2) ◽  
pp. 86-94 ◽  
Author(s):  
M. J. LEWIS ◽  
A. C. GREY ◽  
A. H. HENDERSON
Keyword(s):  
Heart Muscle ◽  
Isolated Heart

Convenient apparatus for recording contractions of isolated heart muscle

1965 ◽  
Vol 20 (4) ◽  
pp. 755-757 ◽  
Author(s):  
John R. Blinks
Keyword(s):  
Papillary Muscle ◽  
Heart Muscle ◽  
Isolated Heart ◽  
Organ Bath ◽  
Muscle Preparation ◽  
Isolated Atria ◽  
Double Muscle ◽  
Stimulating Electrodes ◽  
Chronotropic Effects ◽  
Isolated Organ Bath

A simple and convenient apparatus for physiological or pharmacological experiments on preparations of isolated heart muscle is described. Provision is made for recording independently from two preparations mounted in the same bath. Electrodes for stimulation or recording are incorporated in the clamps that hold the tissue. The construction ensures the maintenance of a high oxygen tension at the surface of the tissue without the mechanical artifacts that result from bubbling oxygen directly past it. papillary muscle; isolated organ bath; isolated atria; double muscle preparation; circulating salt solution; stimulating electrodes; concentration-effect curves; inotropic and chronotropic effects; oxygenation Submitted on November 5, 1964

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