The Role of Free Radicals as Mediators of Endothelial Cell Injury in Hyperhomocysteinemia

1992 ◽  
Vol 161 (9) ◽  
pp. 561-564 ◽  
Author(s):  
R. Clarke ◽  
E. Naughten ◽  
S. Cahalane ◽  
K. O. Sullivan ◽  
P. Mathias ◽  
...  
Keyword(s):  
Free Radicals ◽  
Endothelial Cell ◽  
Cell Injury ◽  
Endothelial Cell Injury

NHE blockade inhibits chemokine production and NF-κB activation in immunostimulated endothelial cells

2002 ◽  
Vol 283 (2) ◽  
pp. C396-C403 ◽  
Author(s):  
Zoltán H. Németh ◽  
Edwin A. Deitch ◽  
Qi Lu ◽  
Csaba Szabó ◽  
György Haskó
Keyword(s):  
Endothelial Cell ◽  
Inflammatory Response ◽  
Cell Injury ◽  
Suppressive Effect ◽  
Nuclear Factor ◽  
Chemokine Production ◽  
Endothelial Cell Injury ◽  
Monocyte Chemoattractant ◽  
Maximal Activation

Na+/H+exchanger (NHE) activation has been documented to contribute to endothelial cell injury caused by inflammatory states. However, the role of NHEs in regulation of the endothelial cell inflammatory response has not been investigated. The present study tested the hypothesis that NHEs contribute to endothelial cell inflammation induced by endotoxin or interleukin (IL)-1β. NHE inhibition using amiloride, 5-( N-ethyl- N-isopropyl)-amiloride, and 5-( N-methyl- N-isobutyl)amiloride as well as the non-amiloride NHE inhibitors cimetidine, clonidine, and harmaline suppressed endotoxin-induced IL-8 and monocyte chemoattractant protein (MCP)-1 production by human umbilical endothelial vein cells (HUVECs). The suppressive effect of amiloride on endotoxin-induced IL-8 production was associated with a decreased accumulation of IL-8 mRNA. NHE inhibitors suppressed both inhibitory (I)κB degradation and nuclear factor (NF)-κB DNA binding, suggesting that a decrease in activation of the IκB-NF-κB system contributed to the suppression of HUVEC inflammatory response by NHE blockade. NHE inhibition decreased also the IL-1β-induced HUVEC inflammatory response, because amiloride suppressed IL-1β-induced E-selectin expression on HUVECs. These results demonstrate that maximal activation of the HUVEC inflammatory response requires a functional NHE.

scholarly journals The Role of Endothelial Cell Injury in Thrombotic Microangiopathy

2010 ◽  
Vol 56 (6) ◽  
pp. 1168-1174 ◽  
Author(s):  
Ryan J. Goldberg ◽  
Takahiko Nakagawa ◽  
Richard J. Johnson ◽  
Joshua M. Thurman
Keyword(s):  
Endothelial Cell ◽  
Thrombotic Microangiopathy ◽  
Cell Injury ◽  
Endothelial Cell Injury

scholarly journals Homocystine-induced arteriosclerosis. The role of endothelial cell injury and platelet response in its genesis.

1976 ◽  
Vol 58 (3) ◽  
pp. 731-741 ◽  
Author(s):  
L A Harker ◽  
R Ross ◽  
S J Slichter ◽  
C R Scott
Keyword(s):  
Endothelial Cell ◽  
Cell Injury ◽  
Platelet Response ◽  
Endothelial Cell Injury

The Role of Endothelial Cell Injury and Platelet Response in Atherogenesis

1978 ◽  
Vol 39 (02) ◽  
pp. 312-321 ◽  
Author(s):  
Laurence A Harker ◽  
Russell Ross ◽  
John A Glomset
Keyword(s):  
Endothelial Cell ◽  
Cell Injury ◽  
Platelet Response ◽  
Endothelial Cell Injury
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