Three basic patterns of changes in serum thyroid hormone levels in Graves’ disease during the one-year period after radioiodine therapy

2005 ◽  
Vol 19 (4) ◽  
pp. 297-308 ◽  
Author(s):  
Masayuki Nakajo ◽  
Shinsaku Tsuchimochi ◽  
Hiroaki Tanabe ◽  
Yoshiaki Nakabeppu ◽  
Megumi Jinguji
1998 ◽  
Vol 13 (8) ◽  
pp. 419-420 ◽  
Author(s):  
J Rudolf ◽  
M Grond ◽  
M Neveling ◽  
W-D Heiss

SummaryWe report a 27-year-old female patient with prior history of Graves' disease and relapsing episodes of tachycardia, hyperpyrexia, muscular rigidity and coma. With the subsequent manifestation of an acute schizophreniform psychotic disorder unresponsive to neuroleptics, the primary syndrome was re-classified as febrile catatony. Hyperthyroidism was ruled out with normal serum thyroid hormone levels, as were toxic effects of thyrostatic treatment, drug-induced hypothyroidism and a malignant neuroleptic syndrome. All psychiatric symptoms subsided completely following subtotal thyroidectomy. Febrile catatatony has to be added to the spectrum of psychotic phenomena that may be caused by Graves' disease, irrespective of serum thyroid hormone levels.


2017 ◽  
Vol 6 (4) ◽  
pp. 200-205 ◽  
Author(s):  
Jan Calissendorff ◽  
Henrik Falhammar

Background Graves’ disease is a common cause of hyperthyroidism. Three therapies have been used for decades: pharmacologic therapy, surgery and radioiodine. In case of adverse events, especially agranulocytosis or hepatotoxicity, pre-treatment with Lugol’s solution containing iodine/potassium iodide to induce euthyroidism before surgery could be advocated, but this has rarely been reported. Methods All patients hospitalised due to uncontrolled hyperthyroidism at the Karolinska University Hospital 2005–2015 and treated with Lugol’s solution were included. All electronic files were carefully reviewed manually, with focus on the cause of treatment and admission, demographic data, and effects of iodine on thyroid hormone levels and pulse frequency. Results Twenty-seven patients were included. Lugol’s solution had been chosen due to agranulocytosis in 9 (33%), hepatotoxicity in 2 (7%), other side effects in 11 (41%) and poor adherence to medication in 5 (19%). Levels of free T4, free T3 and heart rate decreased significantly after 5–9 days of iodine therapy (free T4 53–20 pmol/L, P = 0.0002; free T3 20–6.5 pmol/L, P = 0.04; heart rate 87–76 beats/min P = 0.0007), whereas TSH remained unchanged. Side effects were noted in 4 (15%) (rash n = 2, rash and vomiting n = 1, swelling of fingers n = 1). Thyroidectomy was performed in 26 patients (96%) and one was treated with radioiodine; all treatments were without serious complications. Conclusion Treatment of uncontrolled hyperthyroidism with Lugol’s solution before definitive treatment is safe and it decreases thyroid hormone levels and heart rate. Side effects were limited. Lugol’s solution could be recommended pre-operatively in Graves’ disease with failed medical treatment, especially if side effects to anti-thyroid drugs have occurred.


Kanzo ◽  
1978 ◽  
Vol 19 (1) ◽  
pp. 67-74
Author(s):  
Kenichi KITANI ◽  
Masahiko IUCHI ◽  
Kyoko SHIBATA

2012 ◽  
Vol 97 (9) ◽  
pp. 3170-3178 ◽  
Author(s):  
Annemieke J. Lem ◽  
Yolanda B. de Rijke ◽  
Hans van Toor ◽  
Maria A. J. de Ridder ◽  
Theo J. Visser ◽  
...  

1989 ◽  
Vol 87 (5) ◽  
pp. 558-561 ◽  
Author(s):  
Paula T. Trzepacz ◽  
Irwin Klein ◽  
Michelle Roberts ◽  
Joel Greenhouse ◽  
Gerald S. Levey

Critical Care ◽  
2013 ◽  
Vol 17 (S3) ◽  
Author(s):  
J Vidart ◽  
SM Wajner ◽  
BD Schaan ◽  
AL Maia

Author(s):  
Salih Saygin Eker ◽  
Cengiz Akkaya ◽  
Asli Sarandol ◽  
Sengul Cangur ◽  
Emre Sarandol ◽  
...  

1983 ◽  
Vol 29 (10) ◽  
pp. 1866-1867 ◽  
Author(s):  
F L Van de Vyver ◽  
J Kruse ◽  
L Muylle ◽  
O Bouque ◽  
P P Blockx

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