Toxic equivalency factors for dioxin-like PCBs

Ulf G. Ahlborg; Annika Hanberg

doi:10.1007/bf02986503

Toxic equivalency factors for tetra- through octachlorinated dibenzofurans in PLHC-1 fish hepatoma cell line

Marine Environmental Research ◽

10.1016/0141-1136(96)87098-x ◽

1996 ◽

Vol 42 (1-4) ◽

pp. 401

Author(s):

D.E. Tillitt ◽

M. Tysklind ◽

L. Eriksson ◽

K. Lundgren ◽

C. Rappe

Keyword(s):

Cell Line ◽

Hepatoma Cell ◽

Hepatoma Cell Line ◽

Equivalency Factors ◽

Toxic Equivalency Factors

The Utility of Toxic Equivalency Factors (TEFs) in Human and Ecological Risk Assessment

Human and Ecological Risk Assessment An International Journal ◽

10.1080/10807039991289572 ◽

1999 ◽

Vol 5 (1) ◽

pp. 7-8 ◽

Cited By ~ 2

Author(s):

Stephen M. Roberts

Keyword(s):

Risk Assessment ◽

Ecological Risk ◽

Ecological Risk Assessment ◽

Equivalency Factors ◽

Toxic Equivalency Factors

Exposure to mixtures and congeners of polychlorinated biphenyls

Clinical Chemistry ◽

10.1093/clinchem/40.7.1409 ◽

1994 ◽

Vol 40 (7) ◽

pp. 1409-1415 ◽

Cited By ~ 7

Author(s):

S Skerfving ◽

B G Svensson ◽

L Asplund ◽

L Hagmar

Keyword(s):

Polychlorinated Biphenyls ◽

Biological Samples ◽

Total Pcbs ◽

Limited Information ◽

Biomarkers Of Exposure ◽

Equivalency Factors ◽

Specific Analysis ◽

Toxic Equivalency Factors ◽

Toxic Equivalents ◽

The Relationship

Abstract There are 209 congeners of polychlorinated biphenyls (PCBs), the metabolism and toxicity of which vary by congeners. Use of PCBs is now restricted, but environmental contamination and human exposure persist. Analysis for "total PCBs" in biological samples gives limited information; congener-specific analysis is far more informative, but more complicated. Concentrations of congeners in serum/plasma, adipose tissue, or milk are useful biomarkers of exposure. Lipids may contain similar concentrations and congener patterns, but these vary between exposures and are different from those of the corresponding exposure mixtures; hence, analysis of lipids cannot be used to identify the original exposure. Some non- and mono-ortho congeners may attain a coplanar conformation, which renders them capable of a dioxin-like action. Toxic equivalency factors (TEFs) have been used to sum that risk as toxic equivalents (TEQs), which are considerably different from congener concentrations. No reliable data have been developed on the relationship between concentrations of "total PCBs" or congeners in biological samples and effects of PCBs on human health, mainly because of the various analytical procedures involved and confounding exposures.

Development of toxic equivalency factors for PCB congeners and the assessment of TCDD and PCB mixtures in rainbow trout

Environmental Toxicology and Chemistry ◽

10.1002/etc.5620140518 ◽

1995 ◽

Vol 14 (5) ◽

pp. 861-871 ◽

Cited By ~ 58

Author(s):

John L. Newsted ◽

Paul D. Jones ◽

John P. Giesy ◽

Robert A. Crawford ◽

Gerald T. Ankley ◽

...

Keyword(s):

Rainbow Trout ◽

Pcb Congeners ◽

Equivalency Factors ◽

Toxic Equivalency Factors

TOXIC EQUIVALENCY FACTORS CAN UNIFY EXPOSURE PARAMETERS IN ENVIRONMENTAL EPIDEMIOLOGY

Epidemiology ◽

10.1097/00001648-199607001-00279 ◽

1996 ◽

Vol 7 (Supplement) ◽

pp. S88

Author(s):

C E EASTERLY

Keyword(s):

Environmental Epidemiology ◽

Equivalency Factors ◽

Toxic Equivalency Factors

Development, validation and limitations of toxic equivalency factors

Chemosphere ◽

10.1016/0045-6535(92)90480-f ◽

1992 ◽

Vol 25 (1-2) ◽

pp. 61-64 ◽

Cited By ~ 73

Author(s):

S. Safe

Keyword(s):

Equivalency Factors ◽

Toxic Equivalency Factors

The 2005 WHO re-evaluation of toxic equivalency factors for dioxin like compounds—Implications for risk assessment and limitations of the concept

Toxicology Letters ◽

10.1016/j.toxlet.2006.06.116 ◽

2006 ◽

Vol 164 ◽

pp. S55-S56 ◽

Cited By ~ 6

Author(s):

Martin Van den Berg

Keyword(s):

Risk Assessment ◽

Equivalency Factors ◽

Toxic Equivalency Factors

Development of a laboratory analytical method beneficial to the policies of the Canada-wide standards for dioxins and furans

10.32920/ryerson.14652477 ◽

2021 ◽

Author(s):

Eric Paul Buan

Keyword(s):

Correction Factor ◽

Operating Cost ◽

Cost Savings ◽

World Health ◽

Enzyme Linked Immunosorbent Assay ◽

Equivalency Factors ◽

Soils And Sediments ◽

Toxic Equivalency Factors ◽

Toxic Equivalents ◽

Health Organization

An enzyme-linked immunosorbent assay (ELISA) was tested for its ability to screen for PCDD/F in soils and sediments at 50, 1000 and 10,000 picograms toxic equivalents per gram of soil pgTEQ g-₁ (n=48, r²=0.994, slope=0.94). These results relied on two concepts developed in this thesis. The first, a congener correction factor, corrects ELISA results for differences in how ELISA and GC-HRMS calculate the dioxin content of a sample. The congener correction factor increased the correlation between ELISA and GC-HRMS TEQ values calculated using World Health Organization (WHO) toxic equivalency factors (TEF) from 83% to 94%. The correlation between ELISA and GC-HRMS TEQ values calculated using North Atlantic Treaty Organization (NATO) TEF remained strong when the correction factor was applied, falling from 102% to 94%. The second concept, a sample algorithm allows ELIAS to efficiently measure unknown PCDD/F concentrations between 30 and 10,5000 pgTEQ g-¹. The algorithm successfully placed 24 of 28 samples into their correct concentration ranges in a maximum of two ELISA each. A cost analysis of using the algorithm predicted that ELISA can screen samples three times faster than GC-HRMS while at a 60% reduction in operating cost. The success of ELISA in conjunction with its time and cost savings indicate that it can replace GC-HRMS in situations where the high precision of GC-HRMS is not required.