Estrogen receptor expression in salivary gland mucoepidermoid carcinoma and adenoid cystic carcinoma

2004 ◽  
Vol 10 (3) ◽  
pp. 166-168 ◽  
Author(s):  
Fábio Ramôa Pires ◽  
Danyel Elias da Cruz Perez ◽  
Oslei Paes de Almeida ◽  
Luiz Paulo Kowalski
Keyword(s):  
Estrogen Receptor ◽  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Mucoepidermoid Carcinoma ◽  
Receptor Expression ◽  
Estrogen Receptor Expression ◽  
Adenoid Cystic

scholarly journals Immunohistochemical Study of Estrogen Receptor Expression in Adenoid Cystic Carcinoma and Mucoepidermoid Carcinoma of the Salivary Gland

2016 ◽  
Vol 8 (2) ◽  
pp. 3-3
Author(s):  
Seyed Hossein Tabatabaei ◽  
Najmeh Jafari ◽  
Mahmood Akhavan Tafti ◽  
Ali Tavakoli Hosseini
Keyword(s):  
Estrogen Receptor ◽  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Mucoepidermoid Carcinoma ◽  
Immunohistochemical Study ◽  
Receptor Expression ◽  
Estrogen Receptor Expression ◽  
Adenoid Cystic

Kallikrein-related peptidase 10 expression in salivary gland tissues and tumours

2012 ◽  
Vol 27 (4) ◽  
pp. 381-388 ◽  
Author(s):  
Mark R. Darling ◽  
Nelly N. Hashem ◽  
Irene Zhang ◽  
Mohamed Mohamed ◽  
Kevin Fung ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Mucoepidermoid Carcinoma ◽  
Salivary Gland Tumour ◽  
Immunoperoxidase Staining ◽  
Aberrant Expression ◽  
Adenoid Cystic ◽  
Gland Tumour

Objectives Kallikrein-related peptidase 10 (KLK10) has been implicated in the development of several types of cancer. The purpose of this study was to analyze the expression of KLK10 in 3 types of salivary gland tumour and normal salivary glands. Materials and methods: A standard immunoperoxidase staining technique was used to assess the Immunoexpression profile of KLK10 in normal salivary glands and 3 types of salivary gland tumour: pleomorphic adenoma, adenoid cystic carcinoma and mucoepidermoid carcinoma. Results Pleomorphic adenomas showed significantly lower KLK10 levels than control tissues. Neither of the malignant tumours (adenoid cystic carcinoma and mucoepidermoid carcinoma) showed a significant alteration in the immunoreactive scores of KLK10 in comparison with the normal salivary gland tissues. KLK10 immunoreactive scores were comparable in adenoid cystic carcinoma and mucoepidermoid carcinoma. Pleomorphic adenoma had significantly lower levels of KLK10 than mucoepidermoid carcinoma. Conclusions The finding of lower KLK10 levels in pleomorphic adenoma suggests aberrant expression in a tumour that develops primarily from myoepithelial cells. A kallikrein cascade may play a role in the development and/or outcome of some salivary gland tumours.

scholarly journals Multiple Malignant Salivary Gland Neoplasms: Mucoepidermoid Carcinoma of Palate and Adenoid Cystic Carcinoma of Floor of Mouth

2007 ◽  
Vol 2 (1) ◽  
pp. 41-48 ◽  
Author(s):  
Joseph C. Whitt ◽  
Duane R. Schafer ◽  
Michael D. Callihan
Keyword(s):  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Mucoepidermoid Carcinoma ◽  
Salivary Gland Neoplasms ◽  
Floor Of Mouth ◽  
Adenoid Cystic

scholarly journals GAMBARAN HISTOPATOLOGI TUMOR KELENJAR LIUR DI MANADO PERIODE JULI 2010 – JULI 2013

e-CliniC ◽  
2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Marcella P. J. Merung
Keyword(s):  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Salivary Glands ◽  
Mucoepidermoid Carcinoma ◽  
Cell Lymphoma ◽  
Large Cell ◽  
Basal Cell Adenoma ◽  
Cell Adenoma ◽  
Adenoid Cystic ◽  
Large Cell Lymphoma

Abstract: Salivary glands tumor is relatively rare. In Indonesia, there’s still no complete data about the estimated incidence of salivary glands tumor. Objective:To determine the histopathology of the salivary gland tumor in Manado from July 2010 to July 2013. Methode: This was a descriptive retrospective study. Result: There were 70 patients had salivary gland tumorswith52.9% femaleand47.1% male). By age groups found that ≤16 age group for 1,4%, 17 - 30 for 28.6%, 31 – 40 for18.%), 41 – 50 for21.4%, 51 – 60 for14.3%, 61 – 70 for8.6%, ≥71 for 7.1%. By classification histopathology, Pleiomorphic adenoma for 57.2%, Whartin’s tumor for 11.4%, Oncocytoma, Mucoepidermoid carcinoma, and Adenocarcinoma each for 5.7%, Adenoid cystic carcinoma for4.3%,Cystadenoma for 3.0%, Myoepithelioma, Basal cell adenoma, Canalicular adenoma, Cystadenocarcinoma,and Large cell lymphoma malignant each for 1.4%. By the location, parotis gland for 47.1%, submandibula gland for 27.1%, minor salivary gland for 12.9% and the other location for 12.9%. Conclusion: Female is more than male, the highest incidence is in the group 17-30 years old, the most common benign tumors is pleomorphic adenoma while the most common type of malignant tumors is mucoepidermoid carcinoma and adenocarcinoma. The most frequent tumor’s location is parotid gland. Keywords: Salivary glands tumor, histopathology.   Abstrak: Tumor kelenjar liur merupakan tumor yang jarang ditemukan. Indonesia masih belum ada data lengkap mengenai insiden tumor kelenjar liur.Tujuan: Untuk mengetahui gambaran histopatologi tumor kelenjar liur di Manado periode Juli 2010 – Juli 2013. Metode:Penelitian ini bersifat deskriptif retrospektif. Hasil: Dari 70 penderita tumor kelenjar liurditemukan perempuan 52,9% dan laki-laki 47,1%. Kelompok usia ≤16 tahun sebanyak 1,4%, 17 - 30 tahun sebanyak 28,6%,31 – 40 tahun sebanyak 18,6%, 41 – 50 tahun sebanyak 21,4%, 51 – 60 tahun sebanyak 14,3%, 61 – 70 tahun sebanyak 8,6%, ≥71 tahun sebanyak 7,1%. Berdasarkan klasifikasi histopatologi jenis Pleimorphic adenoma sebanyak 57,2%, Whartin’s tumor sebanyak 11,4%, Oncocytoma,Mucoepidermoid carcinoma, dan Adenocarcinoma masing-masing sebanyak 5,7%,Adenoid cystic carcinoma sebanyak 4,3%, Cystadenoma sebanyak 3,0%, Myoepithelioma,Basal cell adenoma,Canalicular adenoma, Cystadenocarcinoma,dan Large cell lymphoma malignant masing-masing sebanyak 1,4%. Berdasarkan lokasi tumor, kelenjar parotis sebanyak 47,1%, kelenjar submandibula sebanyak 27,1%, kelenjar liur minor sebanyak 12,9% dan lokasi yang tidak jelas sebanyak 12,9%. Kesimpulan:Penderita perempuan lebih banyak dari laki-laki, insiden tertinggi pada kelompok usia17 – 30 tahun, tumor jinak paling banyak ditemukan adalah pleomorphic adenoma sedangkan tipe ganas adalah mucoepidermoid carcinoma dan adenocarcinoma. Lokasi tumor tersering adalah kelenjar parotis. Kata Kunci: Tumor kelenjar liur, histopatologi.

Estrogen receptor assay in polymorphous low-grade adenocarcinoma and adenoid cystic carcinoma of salivary gland origin

1994 ◽  
Vol 77 (1) ◽  
pp. 36-40 ◽  
Author(s):  
Arthur S. Miller ◽  
Grace G. Hartman ◽  
Sow-Yeh Chen ◽  
Pamela R. Edmonds ◽  
Signe A. Brightman ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Low Grade ◽  
Adenoid Cystic ◽  
Receptor Assay

scholarly journals Expression of galectin-3 in adenoid cystic carcinoma & mucoepidermoid carcinoma of salivary glands- a study from Pakistan

2017 ◽  
Vol 5 (1) ◽  
pp. 10
Author(s):  
Sunila Hussain ◽  
Muhammad Rashid Siraj ◽  
Rabia Anjum ◽  
Ihtesham-ud-Din Qureshi ◽  
A H Nagi ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Salivary Glands ◽  
Mucoepidermoid Carcinoma ◽  
Tertiary Care ◽  
Cell Types ◽  
Lymph Node Status ◽  
Staining Reaction ◽  
Adenoid Cystic ◽  
Galectin 3

Background: Adenoid cystic carcinoma (AdCC) and mucoepidermoid carcinoma (MEC) are the commonest salivary gland malignancies in Pakistan constituting almost 75% of all malignant salivary gland tumours.Objective: The objective of this study was to determine the expression of galectin-3 (Gal-3) in AdCC and MEC of salivary glands and to see its relationship with histological differentiation in these tumours.Method: This descriptive study was conducted at the Department of Morbid Anatomy and Histopathology/ Oral Pathology, University of Health Sciences Lahore, Pakistan. Biopsies and detailed clinical data of 20 cases each of adenoid cystic carcinoma and mucoepidermoid carcinoma reported at local tertiary care hospitals from Jan. 2014 to Sep. 2015 were retrieved. The histologic diagnosis was made on Hematoxylin and Eosin staining. The tumours were graded into grades I, II & III according to the most recent grading criteria. AdCC was studied with respect to its morphological patterns (tubular, cribriform and solid) while MEC was studied with special concern to the cell types seen in it (mucous, intermediate, squamous and clear cells). Immunohistochemical expression of galectin-3 was determined in these tumours with respect to histological grades, patterns and cell types seen.Results: Moderate positivity (55%) for anti-galectin-3 antibody was the most frequently observed score for galectin-3 in both MEC and AdCC. Moderate positive (55%) staining reaction was followed by weak positive (30%) staining reaction in AdCC. Total score for antigalectin-3 antibody, positive stromal reaction (intensity) and location of cellular signals for anti-galectin-3 antibody were all found to be significantly associated with grades of AdCC. Also, histological pattern of AdCC (tubular, cribriform and solid) were significantly associated with type of anti-galectin-3 staining pattern of cells (p<0.001). In MEC, moderate positive (55%) staining for anti-galectin-3 antibody was followed by strong positive reaction (30%). The total score for anti-galectin-3 antibody was significantly associated with grades of the tumour and lymph node status. Also, the type of staining reaction in cells was significantly associated with cell type (mucous, squamous and intermediate cells).Conclusion: It can be concluded from the current study that expression of Gal-3 decreases with decreasing differentiation in parenchyma of malignant tumours while its expression in tumour extracellular environment increases with increasing grade of the tumour.Also, it can be concluded that nuclear expression of Gal-3 is associated tumour differentiation and cytoplasmic expression with tumour cell proliferation.

scholarly journals Salivary Gland Tumors in Maxillofacial Region: A Retrospective Study of 130 Cases in a Southern Iranian Population

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Mahmoud Shishegar ◽  
Mohamad J. Ashraf ◽  
Negar Azarpira ◽  
Bijan Khademi ◽  
Basir Hashemi ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Retrospective Study ◽  
Adenoid Cystic Carcinoma ◽  
Salivary Glands ◽  
Mucoepidermoid Carcinoma ◽  
Salivary Gland Tumors ◽  
Iranian Population ◽  
Benign Tumors ◽  
Invasive Squamous Cell Carcinoma ◽  
Adenoid Cystic

Tumors of the salivary glands are uncommon head and neck neoplasia. We conducted a retrospective study of 392 cases over the last 6 years in Shiraz, south of Iran, to investigate the clinicopathological features of these tumors in Iranian population. The age of the patients ranged from 8 to 85 years, with the mean age years and male-to-female (M : F) ratio was 1.02 : 1. For benign tumors, there was a propensity towards females, whereas the malignant tumor was more common in males. The ratio of benign tumors to malignancies was 2.19 : 1. Pleomorphic adenoma (PA) was the most common tumor and accounted for 85% of all benign tumors, followed by Warthin's tumor (8.6%). Of the 125 malignancies, adenoid cystic carcinoma (40%), mucoepidermoid carcinoma (24%) and invasive squamous cell carcinoma (16%) were the most common histological types. Most of the salivary gland tumors (75%) originated from major salivary glands and the remained (25%) originated from minor glands. The parotid gland was the most common site both in benign and malignant tumors. Most of our findings were similar to those in the literature, with some variations. The salivary tumors slightly predominated in males. Adenoid cystic carcinoma and mucoepidermoid carcinoma constituted the most common malignancies.

scholarly journals Angiogenesis and Lymphangiogenesis in Salivary Gland Adenoid Cystic Carcinoma and Mucoepidermoid Carcinoma

2019 ◽  
Vol 20 (12) ◽  
pp. 3547-3553
Author(s):  
Mohammad Koochek Dezfuli ◽  
Maryam Seyedmajidi ◽  
Shima Nafarzadeh ◽  
Farzad Yazdani ◽  
Ali Bijani
Keyword(s):  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Mucoepidermoid Carcinoma ◽  
Adenoid Cystic

Study of FHIT and WWOX expression in mucoepidermoid carcinoma and adenoid cystic carcinoma of salivary gland

Oral Oncology ◽  
2010 ◽  
Vol 46 (3) ◽  
pp. 195-199 ◽  
Author(s):  
Nazmiye Dincer ◽  
Gaye Güler Tezel ◽  
Arzu Sungur ◽  
Cigdem Himmetoglu ◽  
Kay Huebner ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Mucoepidermoid Carcinoma ◽  
Adenoid Cystic

scholarly journals SALIVARY GLANDS;

2017 ◽  
Vol 24 (11) ◽  
pp. 1661-1668
Author(s):  
Sunila Hussain ◽  
Nadia Naseem ◽  
Muhammad Rashid Siraj ◽  
Fakeha Rehman ◽  
Ihtesham-u-Din Qureshi ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Adenoid Cystic Carcinoma ◽  
Salivary Glands ◽  
Mucoepidermoid Carcinoma ◽  
Local Population ◽  
Age Group ◽  
Equal Distribution ◽  
Adenoid Cystic ◽  
Grade Iii

Objectives: Adenoid cystic carcinoma (AdCC) and mucoepidermoid carcinoma(MEC) are the commonest salivary gland malignancies in Pakistan constituting almost 75%of all malignant salivary gland tumours. The objective of this study was explore the clinical &morphological spectrum of these tumours in local population and to grade them w.r.t. moderngrading criteria. Study Design: Descriptive study. Setting: Department of Morbid Anatomy andHistopathology/ Oral Pathology, University of Health Sciences Lahore, Pakistan. Period: Jan.2014 to Sep. 2015. Method: Paraffin embedded blocks and detailed clinical data of 20 caseseach of adenoid cystic carcinoma and mucoepidermoid carcinoma reported at local tertiarycare hospitals. The histologic diagnosis was made on Hematoxylin and Eosin staining. Thetumours were graded into grades I, II & III according to the most recent grading criteria. AdCCwas studied with respect to its morphological patterns (tubular, cribriform and solid) while MECwas studied with special concern to the cell types seen in it (mucous, intermediate, squamousand clear cells). Results: The most frequently observed age group for the patients of AdCCwas the 5th (45%) decade with mean age of 41.50±12.224 years and a female predilection of1.5:1. Minor salivary glands were the commonest site involved (80%) of which palate was mostfrequently affected (37.5%) followed by maxilla (25%). Grade I (75%) was most frequently notedgrade in AdCC. Cribriform pattern (60%) was the most frequently encountered predominanthistological pattern followed by equal distribution of tubular and solid Patterns (20% each).MEC affected most patients in 3rd (30%) decade with mean age of and 32.35±13.674 yearsand male predilection (60%). Parotid gland (70%) was the commonest site involved followedby maxilla (10%). Histologically, grade III (40%) was most frequently noted followed by gradeI (35%) and grade II (25%). Squamous cells (65%) were the predominant cell type in mostcases followed by mucous cells in (35%) cases. Conclusion: Adenoid cystic carcinoma andmucoepidermoid carcinoma both affect a younger age group in our population with a female(1.5:1) and male (1:1.5) predilection respectively. The most favoured site for AdCC and MEC ispalate and parotid gland respectively. Grade I AdCC and cribriform pattern are the commonestgrade and pattern encountered in this study. On the other hand, high grade (Grade III) MECis the most regularly encountered grade in MEC. So, proper grading and staging along withmeticulous surgical approach is needed to improve the life expectancy in these patients.

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