scholarly journals GAMBARAN HISTOPATOLOGI TUMOR KELENJAR LIUR DI MANADO PERIODE JULI 2010 – JULI 2013

e-CliniC ◽  
2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Marcella P. J. Merung
Keyword(s):  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Salivary Glands ◽  
Mucoepidermoid Carcinoma ◽  
Cell Lymphoma ◽  
Large Cell ◽  
Basal Cell Adenoma ◽  
Cell Adenoma ◽  
Adenoid Cystic ◽  
Large Cell Lymphoma

Abstract: Salivary glands tumor is relatively rare. In Indonesia, there’s still no complete data about the estimated incidence of salivary glands tumor. Objective:To determine the histopathology of the salivary gland tumor in Manado from July 2010 to July 2013. Methode: This was a descriptive retrospective study. Result: There were 70 patients had salivary gland tumorswith52.9% femaleand47.1% male). By age groups found that ≤16 age group for 1,4%, 17 - 30 for 28.6%, 31 – 40 for18.%), 41 – 50 for21.4%, 51 – 60 for14.3%, 61 – 70 for8.6%, ≥71 for 7.1%. By classification histopathology, Pleiomorphic adenoma for 57.2%, Whartin’s tumor for 11.4%, Oncocytoma, Mucoepidermoid carcinoma, and Adenocarcinoma each for 5.7%, Adenoid cystic carcinoma for4.3%,Cystadenoma for 3.0%, Myoepithelioma, Basal cell adenoma, Canalicular adenoma, Cystadenocarcinoma,and Large cell lymphoma malignant each for 1.4%. By the location, parotis gland for 47.1%, submandibula gland for 27.1%, minor salivary gland for 12.9% and the other location for 12.9%. Conclusion: Female is more than male, the highest incidence is in the group 17-30 years old, the most common benign tumors is pleomorphic adenoma while the most common type of malignant tumors is mucoepidermoid carcinoma and adenocarcinoma. The most frequent tumor’s location is parotid gland. Keywords: Salivary glands tumor, histopathology.   Abstrak: Tumor kelenjar liur merupakan tumor yang jarang ditemukan. Indonesia masih belum ada data lengkap mengenai insiden tumor kelenjar liur.Tujuan: Untuk mengetahui gambaran histopatologi tumor kelenjar liur di Manado periode Juli 2010 – Juli 2013. Metode:Penelitian ini bersifat deskriptif retrospektif. Hasil: Dari 70 penderita tumor kelenjar liurditemukan perempuan 52,9% dan laki-laki 47,1%. Kelompok usia ≤16 tahun sebanyak 1,4%, 17 - 30 tahun sebanyak 28,6%,31 – 40 tahun sebanyak 18,6%, 41 – 50 tahun sebanyak 21,4%, 51 – 60 tahun sebanyak 14,3%, 61 – 70 tahun sebanyak 8,6%, ≥71 tahun sebanyak 7,1%. Berdasarkan klasifikasi histopatologi jenis Pleimorphic adenoma sebanyak 57,2%, Whartin’s tumor sebanyak 11,4%, Oncocytoma,Mucoepidermoid carcinoma, dan Adenocarcinoma masing-masing sebanyak 5,7%,Adenoid cystic carcinoma sebanyak 4,3%, Cystadenoma sebanyak 3,0%, Myoepithelioma,Basal cell adenoma,Canalicular adenoma, Cystadenocarcinoma,dan Large cell lymphoma malignant masing-masing sebanyak 1,4%. Berdasarkan lokasi tumor, kelenjar parotis sebanyak 47,1%, kelenjar submandibula sebanyak 27,1%, kelenjar liur minor sebanyak 12,9% dan lokasi yang tidak jelas sebanyak 12,9%. Kesimpulan:Penderita perempuan lebih banyak dari laki-laki, insiden tertinggi pada kelompok usia17 – 30 tahun, tumor jinak paling banyak ditemukan adalah pleomorphic adenoma sedangkan tipe ganas adalah mucoepidermoid carcinoma dan adenocarcinoma. Lokasi tumor tersering adalah kelenjar parotis. Kata Kunci: Tumor kelenjar liur, histopatologi.

Kallikrein-related peptidase 10 expression in salivary gland tissues and tumours

2012 ◽  
Vol 27 (4) ◽  
pp. 381-388 ◽  
Author(s):  
Mark R. Darling ◽  
Nelly N. Hashem ◽  
Irene Zhang ◽  
Mohamed Mohamed ◽  
Kevin Fung ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Mucoepidermoid Carcinoma ◽  
Salivary Gland Tumour ◽  
Immunoperoxidase Staining ◽  
Aberrant Expression ◽  
Adenoid Cystic ◽  
Gland Tumour

Objectives Kallikrein-related peptidase 10 (KLK10) has been implicated in the development of several types of cancer. The purpose of this study was to analyze the expression of KLK10 in 3 types of salivary gland tumour and normal salivary glands. Materials and methods: A standard immunoperoxidase staining technique was used to assess the Immunoexpression profile of KLK10 in normal salivary glands and 3 types of salivary gland tumour: pleomorphic adenoma, adenoid cystic carcinoma and mucoepidermoid carcinoma. Results Pleomorphic adenomas showed significantly lower KLK10 levels than control tissues. Neither of the malignant tumours (adenoid cystic carcinoma and mucoepidermoid carcinoma) showed a significant alteration in the immunoreactive scores of KLK10 in comparison with the normal salivary gland tissues. KLK10 immunoreactive scores were comparable in adenoid cystic carcinoma and mucoepidermoid carcinoma. Pleomorphic adenoma had significantly lower levels of KLK10 than mucoepidermoid carcinoma. Conclusions The finding of lower KLK10 levels in pleomorphic adenoma suggests aberrant expression in a tumour that develops primarily from myoepithelial cells. A kallikrein cascade may play a role in the development and/or outcome of some salivary gland tumours.

Congenital Hybrid Basal Cell Adenoma—Adenoid Cystic Carcinoma of the Salivary Gland

1986 ◽  
Vol 6 (2-3) ◽  
pp. 199-208 ◽  
Author(s):  
Preston R. Simpson ◽  
Joe C. Rutledge ◽  
Steven D. Schaefer ◽  
Robert C. Anderson
Keyword(s):  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Basal Cell ◽  
Basal Cell Adenoma ◽  
Cell Adenoma ◽  
Adenoid Cystic

scholarly journals PROFIL PENDERITA TUMOR KELENJAR LIUR DI RSUP PROF. DR. R.D. KANDOU MANADO PERIODE JULI 2012-JUNI 2015

e-CliniC ◽  
2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Wirawan Iman ◽  
Marselus Merung ◽  
Ainun Aschorijanto
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Cell Carcinoma ◽  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Basal Cell ◽  
Mucoepidermoid Carcinoma ◽  
Acinic Cell Carcinoma ◽  
Basal Cell Adenoma ◽  
Cell Adenoma

Abstract: Salivary glands tumours are relatively rare to find. There is still no adequate data about the incidence of salivary gland tumours in Indonesia. The main objective of this research was to cognise the profile of salivary glands tumours patients in Prof. Dr. R.D. Kandou Central General Hospital Manado from July 2012 to June 2015. Methods used is descriptive retrospective. The results showed there are 37 patients with salivary gland(s) tumour(s). Male was 59,5% and female was 40,5%. By age groups found that <19 years for 2.7%, 19-30 years for 8,2%, 31-45 years for 21.6%, 46-60 years for 37,8%, >60 years for 29,7%. Based on the histopathological classification, pleomorphic adenoma for 56.8%, Whartin's tumor for 8.1%, myoepithelioma for 2,7%, basal cell adenoma for 2.7%, oncocytoma for 2.7%, cystadenoma for 5.4%, canalicular adenoma for 2.7%, mucoepidermoid carcinoma for 10.8%, adenocarcinoma for 5.4%, and acinic cell carcinoma for 2.7%. Based on the location of the tumours’ appearance, parotid gland for 83.8%, submandibular gland for 13.5%, minor salivary glands for 2.7%. Based by the incidences annually, first year for 21.6%, second year for 32.3%, and the third year for 46.1%.Conclusion: Males are more than females, most commonly found in the age group of 51-60 years, the most commonly benign tumour found is the pleomorphic adenoma, the most commonly found malign tumour is mucoepidermoid carcinoma, the most commonly location of the tumours’ appearance is the parotid gland. The salivary glands tumours continued to increase during the last three years.Suggestion: Still necessary to do further research about salivary glands tumours.Keywords: salivary glands tumours, age, gender, histopathology, location, profileAbstrak : Tumor kelenjar liur adalah tumor yang relatif sedikit dijumpai ditemukan. Belum ditemukan data yang lengkap tentang kejadian tumor kelenjar liur di Indonesia. Tujuan utama dari penelitian ini adalah untuk mengetahui profil penderita tumor kelenjar liur di RSUP Prof. Dr. R.D. Kandou Manado periode Juli 2012-Juni 2015. Metode penelitian yang digunakan adalah deskriptif retrospektif. Hasil penelitian memperlihatkan terdapat 37 penderita tumor kelenjar liur. Laki-laki sebanyak 59,5% dan perempuan 40,5%. Kelompok usia <16 tahun sebanyak 2,7%, 16-30 tahun sebanyak 8,1%, 31-45 tahun sebanyak 21,6%, 46-60 tahun sebanyak 37,8%, >60 tahun sebanyak 29,7%. Berdasarkan klasifikasi histopatologi jenis pleomorphic adenoma sebanyak 56,8%, Whartin’s tumor sebanyak 8,2%, myoepithelioma sebanyak 2,7%, basal cell adenoma sebanyak 2,7%, oncocytoma sebanyak 2,7%, cystadenoma sebanyak 5,4%, canalicular adenoma sebanyak 2,7%, mucoepidermoid carcinoma sebanyak 10,8%, adenocarcinoma sebanyak 5,4%, acinic cell carcinoma sebanyak 2,7%. Berdasarkan lokasi munculnya tumor, kelenjar parotis sebanyak 83,8%, kelenjar submandibula sebanyak 13,5%, kelenjar liur minor sebanyak 2,7%. Berdasarkan jumlah pertahunnya, tahun pertama sebanyak 21,6%, tahun kedua sebanyak 32,3%, dan tahun ketiga sebanyak 46,1%.Kesimpulan : Penderita laki-laki lebih banyak daripada perempuan, paling banyak ditemukan pada kelompok usia 46-60 tahun, tumor jinak yang paling banyak ditemukan adalah pleomorphic adenoma, tumor ganas yang paling banyak ditemukan adalah mucoepidermoid carcinoma, lokasi tersering munculnya tumor adalah kelenjar parotis. Penderita tumor kelenjar liur terus meningkat selama tiga tahun terakhir.Saran : Perlu dilakukan penelitian lebih lanjut tentang tumor kelenjar liurKata Kunci : tumor kelenjar liur, usia, jenis kelamin, histopatologi, lokasi, profil

scholarly journals Expression of galectin-3 in adenoid cystic carcinoma & mucoepidermoid carcinoma of salivary glands- a study from Pakistan

2017 ◽  
Vol 5 (1) ◽  
pp. 10
Author(s):  
Sunila Hussain ◽  
Muhammad Rashid Siraj ◽  
Rabia Anjum ◽  
Ihtesham-ud-Din Qureshi ◽  
A H Nagi ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Salivary Glands ◽  
Mucoepidermoid Carcinoma ◽  
Tertiary Care ◽  
Cell Types ◽  
Lymph Node Status ◽  
Staining Reaction ◽  
Adenoid Cystic ◽  
Galectin 3

Background: Adenoid cystic carcinoma (AdCC) and mucoepidermoid carcinoma (MEC) are the commonest salivary gland malignancies in Pakistan constituting almost 75% of all malignant salivary gland tumours.Objective: The objective of this study was to determine the expression of galectin-3 (Gal-3) in AdCC and MEC of salivary glands and to see its relationship with histological differentiation in these tumours.Method: This descriptive study was conducted at the Department of Morbid Anatomy and Histopathology/ Oral Pathology, University of Health Sciences Lahore, Pakistan. Biopsies and detailed clinical data of 20 cases each of adenoid cystic carcinoma and mucoepidermoid carcinoma reported at local tertiary care hospitals from Jan. 2014 to Sep. 2015 were retrieved. The histologic diagnosis was made on Hematoxylin and Eosin staining. The tumours were graded into grades I, II & III according to the most recent grading criteria. AdCC was studied with respect to its morphological patterns (tubular, cribriform and solid) while MEC was studied with special concern to the cell types seen in it (mucous, intermediate, squamous and clear cells). Immunohistochemical expression of galectin-3 was determined in these tumours with respect to histological grades, patterns and cell types seen.Results: Moderate positivity (55%) for anti-galectin-3 antibody was the most frequently observed score for galectin-3 in both MEC and AdCC. Moderate positive (55%) staining reaction was followed by weak positive (30%) staining reaction in AdCC. Total score for antigalectin-3 antibody, positive stromal reaction (intensity) and location of cellular signals for anti-galectin-3 antibody were all found to be significantly associated with grades of AdCC. Also, histological pattern of AdCC (tubular, cribriform and solid) were significantly associated with type of anti-galectin-3 staining pattern of cells (p<0.001). In MEC, moderate positive (55%) staining for anti-galectin-3 antibody was followed by strong positive reaction (30%). The total score for anti-galectin-3 antibody was significantly associated with grades of the tumour and lymph node status. Also, the type of staining reaction in cells was significantly associated with cell type (mucous, squamous and intermediate cells).Conclusion: It can be concluded from the current study that expression of Gal-3 decreases with decreasing differentiation in parenchyma of malignant tumours while its expression in tumour extracellular environment increases with increasing grade of the tumour.Also, it can be concluded that nuclear expression of Gal-3 is associated tumour differentiation and cytoplasmic expression with tumour cell proliferation.

Basal-cell adenoma of the salivary gland: A benign adenoma that cytologically mimics adenoid cystic carcinoma

1988 ◽  
Vol 4 (4) ◽  
pp. 342-346 ◽  
Author(s):  
Michael W. Stanley ◽  
Charles A. Horwitz ◽  
Michelle J. Henry ◽  
Linda G. Burton ◽  
Torsten Lowhagen
Keyword(s):  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Basal Cell ◽  
Basal Cell Adenoma ◽  
Cell Adenoma ◽  
Adenoid Cystic ◽  
Benign Adenoma

scholarly journals Salivary Gland Tumors in Maxillofacial Region: A Retrospective Study of 130 Cases in a Southern Iranian Population

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Mahmoud Shishegar ◽  
Mohamad J. Ashraf ◽  
Negar Azarpira ◽  
Bijan Khademi ◽  
Basir Hashemi ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Retrospective Study ◽  
Adenoid Cystic Carcinoma ◽  
Salivary Glands ◽  
Mucoepidermoid Carcinoma ◽  
Salivary Gland Tumors ◽  
Iranian Population ◽  
Benign Tumors ◽  
Invasive Squamous Cell Carcinoma ◽  
Adenoid Cystic

Tumors of the salivary glands are uncommon head and neck neoplasia. We conducted a retrospective study of 392 cases over the last 6 years in Shiraz, south of Iran, to investigate the clinicopathological features of these tumors in Iranian population. The age of the patients ranged from 8 to 85 years, with the mean age years and male-to-female (M : F) ratio was 1.02 : 1. For benign tumors, there was a propensity towards females, whereas the malignant tumor was more common in males. The ratio of benign tumors to malignancies was 2.19 : 1. Pleomorphic adenoma (PA) was the most common tumor and accounted for 85% of all benign tumors, followed by Warthin's tumor (8.6%). Of the 125 malignancies, adenoid cystic carcinoma (40%), mucoepidermoid carcinoma (24%) and invasive squamous cell carcinoma (16%) were the most common histological types. Most of the salivary gland tumors (75%) originated from major salivary glands and the remained (25%) originated from minor glands. The parotid gland was the most common site both in benign and malignant tumors. Most of our findings were similar to those in the literature, with some variations. The salivary tumors slightly predominated in males. Adenoid cystic carcinoma and mucoepidermoid carcinoma constituted the most common malignancies.

scholarly journals Differential challenges in salivary gland neoplasms

2021 ◽  
pp. 2-2
Author(s):  
Nikola Zivkovic ◽  
Milos Kostic ◽  
Ana Cvetanovic ◽  
Maja Jovicic-Milentijevic ◽  
Milan Spasic ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Optical Density ◽  
Morphometric Analysis ◽  
Malignant Tumors ◽  
Basal Cell Adenoma ◽  
Proliferative Index ◽  
Cell Adenoma ◽  
Adenoid Cystic ◽  
Integrated Optical

Salivary gland tumors are neoplasms characterized by a high level of pleomorphism and histological overlap. One tumor may contain several cell types; therefore, it is necessary to include immunohistochemical staining, as well as morphometric analysis of tumor cells as prerequisites for an appropriate diagnosis. Our research included 120 tumors, such as pleomorphic adenoma, Warthin tumor, basal cell adenoma, myoepithelioma, adenoid cystic carcinoma, mucoepidermoid carcinoma, salivary duct carcinoma, polymorphous low-grade carcinoma and myoepithelial carcinoma. The aim of the study was to differentiate benign and malignant tumors based on the characteristics of nuclei. The expression of Ki67 and the morphometric nuclear parameters - area, perimeter, Feret diameter, integrated optical density, circularity, and roundness, were analyzed. It was observed that the Ki67 proliferative index was statistically significantly higher in malignant tumors (P<0.001). Adenoid cystic carcinoma exhibited the highest value, whereas the lowest value was exhibited in basal cell adenoma. Morphometric analysis showed statistically significantly increased values of integrated optical density (P<0.001) and nuclear size parameters (P<0.05) in malignant tumors. The determination of the Ki67 proliferative index and morphometric analysis of the integrated optical density and area can differentiate benign from malignant tumors with high precision. The presented values suggest the obtained results as cut-off values.

scholarly journals SALIVARY GLANDS;

2017 ◽  
Vol 24 (11) ◽  
pp. 1661-1668
Author(s):  
Sunila Hussain ◽  
Nadia Naseem ◽  
Muhammad Rashid Siraj ◽  
Fakeha Rehman ◽  
Ihtesham-u-Din Qureshi ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Adenoid Cystic Carcinoma ◽  
Salivary Glands ◽  
Mucoepidermoid Carcinoma ◽  
Local Population ◽  
Age Group ◽  
Equal Distribution ◽  
Adenoid Cystic ◽  
Grade Iii

Objectives: Adenoid cystic carcinoma (AdCC) and mucoepidermoid carcinoma(MEC) are the commonest salivary gland malignancies in Pakistan constituting almost 75%of all malignant salivary gland tumours. The objective of this study was explore the clinical &morphological spectrum of these tumours in local population and to grade them w.r.t. moderngrading criteria. Study Design: Descriptive study. Setting: Department of Morbid Anatomy andHistopathology/ Oral Pathology, University of Health Sciences Lahore, Pakistan. Period: Jan.2014 to Sep. 2015. Method: Paraffin embedded blocks and detailed clinical data of 20 caseseach of adenoid cystic carcinoma and mucoepidermoid carcinoma reported at local tertiarycare hospitals. The histologic diagnosis was made on Hematoxylin and Eosin staining. Thetumours were graded into grades I, II & III according to the most recent grading criteria. AdCCwas studied with respect to its morphological patterns (tubular, cribriform and solid) while MECwas studied with special concern to the cell types seen in it (mucous, intermediate, squamousand clear cells). Results: The most frequently observed age group for the patients of AdCCwas the 5th (45%) decade with mean age of 41.50±12.224 years and a female predilection of1.5:1. Minor salivary glands were the commonest site involved (80%) of which palate was mostfrequently affected (37.5%) followed by maxilla (25%). Grade I (75%) was most frequently notedgrade in AdCC. Cribriform pattern (60%) was the most frequently encountered predominanthistological pattern followed by equal distribution of tubular and solid Patterns (20% each).MEC affected most patients in 3rd (30%) decade with mean age of and 32.35±13.674 yearsand male predilection (60%). Parotid gland (70%) was the commonest site involved followedby maxilla (10%). Histologically, grade III (40%) was most frequently noted followed by gradeI (35%) and grade II (25%). Squamous cells (65%) were the predominant cell type in mostcases followed by mucous cells in (35%) cases. Conclusion: Adenoid cystic carcinoma andmucoepidermoid carcinoma both affect a younger age group in our population with a female(1.5:1) and male (1:1.5) predilection respectively. The most favoured site for AdCC and MEC ispalate and parotid gland respectively. Grade I AdCC and cribriform pattern are the commonestgrade and pattern encountered in this study. On the other hand, high grade (Grade III) MECis the most regularly encountered grade in MEC. So, proper grading and staging along withmeticulous surgical approach is needed to improve the life expectancy in these patients.

Estrogen receptor expression in salivary gland mucoepidermoid carcinoma and adenoid cystic carcinoma

2004 ◽  
Vol 10 (3) ◽  
pp. 166-168 ◽  
Author(s):  
Fábio Ramôa Pires ◽  
Danyel Elias da Cruz Perez ◽  
Oslei Paes de Almeida ◽  
Luiz Paulo Kowalski
Keyword(s):  
Estrogen Receptor ◽  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Mucoepidermoid Carcinoma ◽  
Receptor Expression ◽  
Estrogen Receptor Expression ◽  
Adenoid Cystic

scholarly journals Ki-67 Index in Salivary Gland Neoplasms

2016 ◽  
Vol 6 (1) ◽  
pp. 1-7
Author(s):  
Suma Kaza ◽  
T Jaya Mastan Rao ◽  
Anupama Mikkilineni ◽  
G Venkata Ratnam ◽  
D Ranga Rao
Keyword(s):  
Salivary Gland ◽  
Pleomorphic Adenoma ◽  
Mucoepidermoid Carcinoma ◽  
Salivary Gland Neoplasms ◽  
Carcinoma Ex Pleomorphic Adenoma ◽  
Myoepithelial Carcinoma ◽  
Cell Adenoma ◽  
Ki 67 ◽  
Adenoid Cystic ◽  
Epithelial Myoepithelial Carcinoma

Abstract Assessment of proliferation is a means of predicting local recurrence and metastatic potential of malignancies. A mitotic count is not an ideal marker for proliferation in certain situations, such as salivary gland neoplasms. Ki-67 expression as a proliferation marker has been investigated in many human tumors. In the present study, Mitotic index (MI) and Ki-67 index were studied in pleomorphic adenoma, basal cell adenoma, mucoepidermoid carcinoma, adenoid cystic carcinoma epithelial myoepithelial carcinoma, carcinoma ex Pleomorphic adenoma and adenocarcinoma of salivary glands. The results were compared. The MI was similar in benign neoplasms, mucoepidermoid carcinoma and epithelial myoepithelial carcinoma, whereas it was high in carcinoma ex pleomorphic adenoma, adenocarcinoma and adenoid cystic carcinoma. The Ki-67 index was different in basal cell adenoma and pleomorphic adenoma. It was helpful in differentiating high grade and low grade mucoepidermoid carcinoma. It highlighted the malignant behavior of epithelial myoepithelial carcinoma. It was concluded that Ki-67 in benign neoplasms is 5% or less and in malignant ones more than 23% with a few exceptions. In mucoepidermoid carcinoma and epithelial myoepithelial carcinoma, Ki-67 index was found to be a better indicator for aggressiveness. These findings will be presented in this paper, with review of literature. How to cite this article Kaza S, Rao TJM, Mikkilineni A, Ratnam GV, Rao DR. Ki-67 Index in Salivary Gland Neoplasms. Int J Phonosurg Laryngol 2016;6(1):1-7.

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