Vergleich von Blutfluß und Benzodiazepin-Rezeptorverteilung bei fokaler Epilepsie: Vorläufige Ergebnisse einer SPECT-Studie

1989 ◽  
Vol 28 (05) ◽  
pp. 181-186
Author(s):  
A. Ludolph ◽  
O. Schober ◽  
G. Lottes ◽  
I. Böttger ◽  
H.-F. Beer ◽  
...  
Keyword(s):  
Human Brain ◽  
Receptor Binding ◽  
Brain Area ◽  
Brain Perfusion ◽  
Partial Epilepsy ◽  
Cerebral Lesion ◽  
Receptor Ligand ◽  
Receptor Mapping ◽  
Hmpao Spect ◽  
99Mtc Hmpao

99mTc-HMPAO-SPECT and SPECT with the 123I-labelled benzodiazepine (Bz) receptor ligand Ro 16-0154 were performed in 10 patients suffering from partial epilepsy, without cerebral lesion in MRT or CT. 2 h p.i. of Ro 16-0154 the distribution of activity correlated with the known distribution of Bz- receptors in the human brain. Perfusion and receptor-binding were found decreased in 7 patients of each study in the suspicious brain-area. 123l-labelled Ro 16-0154 is suitable for Bz-receptor mapping by SPECT. The decrease of Bz-receptor binding in epileptic foci, as described in PET-studies, was also detected by SPECT in 7 of 10 patients.

Atlas of 99mTc-HMPAO SPECT brain perfusion in pediatric brain disorders

2021 ◽  
Vol 2 (2) ◽  
Author(s):  
Saleh A Othman ◽  
Keyword(s):  
Blood Flow ◽  
Neuronal Activity ◽  
Pediatric Patients ◽  
Brain Perfusion ◽  
Brain Disorders ◽  
Hmpao Spect ◽  
Perfusion Scan ◽  
Pediatric Brain ◽  
The Brain ◽  
99Mtc Hmpao

Background: Blood flow to the brain is in parallel with brain metabolism in almost all brain disorders except in brain tumors and therefore regional cerebral blood flow can be used as a marker of metabolic brain activity and hence it is closely linked to neuronal activity, the activity distribution is presumed to reflect neuronal activity levels in different areas of the brain. Purpose: The aim of this work is to demonstrate to pediatrician in general and pediatric neurologist in particular the variations in cerebral perfusion during normal development which should be taken into consideration at the time of interpreting SPECT brain perfusion scan in different pediatric brain disorders. Method: Brain SPECT was performed 10 minutes after an intravenous injection of 11.1 MBq/kg (0.3 mCi/kg), and the minimum dose is 185 MBq (5 mCi) of 99mTc-HMPAO (4). Results: This was a retrospective analysis of SPECT brain perfusion scan of pediatric patients performed between October 2015 and December 2019 at our institution. We selected normal and abnormal studies in pediatric population with age range (5 months - 14 years). Conclusion: Although anatomic cross sectional imaging give details of neurological structural changes, SPECT perfusion mirrors indirectly both metabolic and neuronal activity changes. Therefore, accurate interpretation of SPECT perfusion will consolidate its role as part of the diagnostic protocol and used when the findings of other imaging modalities do not explain the symptoms or fail partially or completely in determining the etiology of brain disorders in pediatric patients.

Vergleich von MRT- und SPECT-Befunden bei Patienten mit zerebraler Mikroangiopathie

1991 ◽  
Vol 30 (05) ◽  
pp. 161-169 ◽  
Author(s):  
C. Weiller ◽  
R. Weigmann ◽  
H.-J. Kaiser ◽  
U. Büll ◽  
R. Schneider ◽  
...  
Keyword(s):  
White Matter Lesions ◽  
Central Nervous System Disease ◽  
Deep White Matter ◽  
Cranial Ct ◽  
System Disease ◽  
Ct Findings ◽  
Hmpao Spect ◽  
Significant Difference ◽  
Cerebral Microangiopathy ◽  
99Mtc Hmpao

Lacunar infarctions and periventricular hypodensity are assumed to be typical CT patterns of cerebral microangiopathy (MA). In 17 patients with such findings and in 6 controls without any signs of central nervous system disease cranial CT, MRT and 99mTc-HMPAO-SPECT were employed. In 7 patients with CT findings of minor MA demonstrated in comparison to controls no significant difference. In 10 cases with CT findings of pronounced MA periventricular rCBF was significantly reduced compared to controls. rCBF of temporal and parietal cortex were not diminished compared to controls. In 14 patients studied with MRT deep white matter lesions were found which appeared solitary, multiple or confluent. Employing 99mTc-HMPAO-SPECT, cerebral MA revealed rCBF reduction in periventricular brain tissue by cerebellar standardization.

Vorläufige Ergebnisse von 99mTc-HMPAO-SPECT-Untersuchungen bei endogenen Psychosen

1989 ◽  
Vol 28 (03) ◽  
pp. 88-91
Author(s):  
J. Schröder ◽  
H. Henningsen ◽  
H. Sauer ◽  
P. Georgi ◽  
K.-R. Wilhelm
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Regions Of Interest ◽  
Post Mortem ◽  
Regional Cerebral Blood ◽  
Hmpao Spect ◽  
Endogenous Psychoses ◽  
The Brain ◽  
99Mtc Hmpao

18 psychopharmacologically treated patients (7 schizophrenics, 5 schizoaffectives, 6 depressives) were studied using 99mTc-HMPAO-SPECT of the brain. The regional cerebral blood flow was measured in three transversal sections (infra-/supraventricular, ventricular) within 6 regions of interest (ROI) respectively (one frontal, one parietal and one occipital in each hemisphere). Corresponding ROIs of the same section in each hemisphere were compared. In the schizophrenics there was a significantly reduced perfusion in the left frontal region of the infraventricular and ventricular section (p < 0.02) compared with the data of the depressives. The schizoaffectives took an intermediate place. Since the patients were treated with psychopharmaca, the result must be interpreted cautiously. However, our findings seem to be in accordance with post-mortem-, CT- and PET-studies presented in the literature. Our results suggest that 99mTc-HMPAO-SPECT may be helpful in finding cerebral abnormalities in endogenous psychoses.

123J-Iomazenil- und 99mTc-HMPAO in der Diagnostik fokaler Epilepsien: Vergleich von unbehandelten und behandelten Patienten

1994 ◽  
Vol 33 (01) ◽  
pp. 01-07
Author(s):  
M. Cordes ◽  
B. Schmitz ◽  
J. Hierholzer ◽  
R. Siekmann ◽  
U. Keske ◽  
...  
Keyword(s):  
Hmpao Spect ◽  
99Mtc Hmpao

ZusammenfassungDie Daten von insgesamt 20 Patienten mit fokalen Epilepsien (beh.: 7; unbeh.: 13) wurden mit dem Ziel ausgewertet, Unterschiede in der Bindung der Radiotracer HMPAO und IM घ zwischen behandelten und unbehandelten Patienten herauszufinden. CT und MIRT zeigten keine pathologischen Befunde. Bei allen Patienten wurden mittels SPECT die Gesamthirnaktivität und durch Anwendung der ROI-Technik regionale Impulsdichten (Rl) bestimmt und der spezifische und unspezifische Anteil der Rl des BZ-Antagonisten für jede Region berechnet. In der Gruppe der beh. Patienten konnte eine signifikant höhere normalisierte Gesamtbindung von IMZ gefunden werden (p <0,001). Die spezifische Bindung von IMZ und die Gesamtbindung von HMPAO zeigten keine Unterschiede zwischen beiden Gruppen. Die IMZ-SPECT hatte in unserem Kollektiv gegenüber der HMPAO-SPECT in bezug auf das EEG eine höhere Sensitivität bei geringerer Spezifität im Nachweis einer Minderanreicherung des Tracers in Arealen mit fokaler hypersynchroner Erregungssteigerung.

Kortikale Dysplasie als epileptogener Fokus: Verminderte Bindung von I-Iomazenil bei unauffälliger 99mTc-HMPAO SPECT

1992 ◽  
Vol 31 (04) ◽  
pp. 142-144
Author(s):  
C. Lehmenkühler ◽  
J. Sciuk ◽  
G. Schuierer ◽  
P. Bartenstein
Keyword(s):  
Hmpao Spect ◽  
99Mtc Hmpao

ZusammenfassungIn kortikalen Arealen, die einem epileptischen Fokus assoziiert sind, korreliert meist eine verminderte Benzodiazepin-Rezeptorbindung, darstellbar mit 123I- Iomazeml, mit einer Minderung des regionalen zerebralen Blutflusses. Anhand eines Fallbeispiels mit ausgeprägter Minderung der 123l-lomazenilbindung im epileptischen Fokus bei ungestörtem regionalen zerebralen Blutfluß wird illustriert und diskutiert, daß bei einer Minderanreicherung von 123I-Iomazenil im epileptischen Fokus eine Alteration des GABAergen Systems anzunehmen ist.

Diagnostik der SDAT mittels HMPAO-SPECT und Serumvitamin-B12-Spiegel

1995 ◽  
Vol 34 (03) ◽  
pp. 104-109 ◽  
Author(s):  
H. J. Gallowitsch ◽  
I. Gomez ◽  
E. Kresnik ◽  
H. Plöb ◽  
P. Lind ◽  
...  
Keyword(s):  
Vitamin B12 ◽  
Hmpao Spect ◽  
99Mtc Hmpao

ZusammenfassungDie alleinige klinische Abklärung dementieller Zustandsbilder, so auch der senilen Demenz vom Alzheimertyp (SDAT), ist schwierig. Durch die Kombination von 99mTc-HMPAO-Gehirn-SPECT und Serumvitamin-B12-Bestimmung erwarteten wir eine Beschleunigung und Verbesserung der Diagnostik der SDAT. Von 116 Patienten, die in 4 Gruppen, entsprechend ihrem 99mTc-HMPAO-Verteilungsmuster eingeteilt worden waren, konnten bei 17 klinisch sehr wahrscheinlichen SDAT-Patienten bei 15 Auffälligkeiten mit Hinweis auf SDAT im Gehirn SPECT gefunden werden. Ein Teil der Patienten wies einen niedrig-normalen bzw. pathologisch niedrigen Vitamin-B12-Spiegel auf. Andere Untersuchungen würden durch die Kombination von Gehirn-SPECT und Serumvitamin-B12-Bestimmung nicht überflüssig werden, obwohl beide Untersuchungen Informationen lieferten, die die Zuordnung zur Diagnose SDAT erleichterten. Die zusätzliche Serumvitamin-B12-Bestimmung stellt keinen wesentlichen Mehraufwand dar.

Absolute SPECT/CT quantification of cerebral uptake of 99mTc-HMPAO for patients with neurocognitive disorders

2016 ◽  
Vol 55 (04) ◽  
pp. 158-165 ◽  
Author(s):  
Friedrich Welz ◽  
James Sanders ◽  
Torsten Kuwert ◽  
Juan Maler ◽  
Johannes Kornhuber ◽  
...  
Keyword(s):  
Tissue Concentration ◽  
Tracer Uptake ◽  
Planar Imaging ◽  
Quantitative Spect ◽  
Dementia Patients ◽  
Hmpao Spect ◽  
Patient Groups ◽  
The Absolute ◽  
99Mtc Hmpao

SummaryIt was reported from planar imaging studies that the cerebral uptake of injected 99mTc-HMPAO activity is about 4–7% in humans. Recent work has shown that modern SPECT/ CT devices are able to quantify the tissue concentration of radioactivity in vivo in absolute units (Bq/ml), while avoiding the limitations of planar techniques. The aims of this study were (a) to determine the cerebral uptake of 99mTc-HMPAO in absolute units in SPECT/CT, (b) to investigate potential differences in absolute tracer uptake for patients suspected of dementia. Patients, methods: We performed 99mTc-HMPAO SPECT/CT in 65 patients with suspected dementia. 99mTc-HMPAO uptake was determined using a previously published quantitative SPECT/CT protocol. The absolute HMPAO uptake and the results of a regionalized analysis were compared for MMSE and NINCDS-ADRDA based patient groups. Results: The mean absolute uptake of 99mTc-HMPAO for our patient population was 4.3 ± 0.8% of the injected dose. The uptake, as well as the regionalized analysis yielded significantly different results for low ( 23) and high (>23) MMSE groups and also for some of the NINCDS-ADRDA groups. Conclusion: Our results show that the absolute cerebral uptake of 99mTc-HMPAO is in the range of previously reported results, obtained by planar techniques. Absolute uptake is significantly different between the patient groups.

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