scholarly journals 4.1 The B Allele of the BsmI Vitamin D Receptor (VDR) Gene Polymorphism is Independently Associated to LVH and to Higher Progression Rate of LVH in End-Stage Renal Disease (ESRD) Patients

2008 ◽  
Vol 15 (3) ◽  
pp. 203-203
Author(s):  
A. Testa ◽  
F. Mallamaci ◽  
F. Benedetto ◽  
A. Pisano ◽  
G. Tripepi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Gene Polymorphism ◽  
Renal Disease ◽  
Vitamin D Receptor ◽  
End Stage Renal Disease ◽  
Progression Rate ◽  
Vdr Gene ◽  
Stage Renal Disease ◽  
End Stage ◽  
Esrd Patients

scholarly journals Association of vitamin D receptor TaqI and ApaI genetic polymorphisms with nephrolithiasis and end stage renal disease: a meta-analysis

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Tajamul Hussain ◽  
Shaik M. Naushad ◽  
Anwar Ahmed ◽  
Salman Alamery ◽  
Arif A. Mohammed ◽  
...  
Keyword(s):  
Vitamin D ◽  
Renal Disease ◽  
Vitamin D Receptor ◽  
End Stage Renal Disease ◽  
Meta Analysis ◽  
Fixed Effect ◽  
Renal Diseases ◽  
Vdr Gene ◽  
Stage Renal Disease ◽  
End Stage

Abstract Background The deficiency of vitamin D receptor (VDR) or its ligand, vitamin D3, is linked to the development of renal diseases. The TaqI (rs731236) and ApaI (rs7975232) polymorphisms of VDR gene are widely studied for their association with renal disease risk. However, studies have largely been ambiguous. Methods Meta-analysis was carried out to clarify the association of TaqI (2777 cases and 3522 controls) and ApaI (2440 cases and 3279 controls) polymorphisms with nephrolithiasis (NL), diabetic nephropathy (DN) and end stage renal disease (ESRD). Results The VDR TaqI C-allele under allele contrast was significantly associated with ESRD in both fixed effect and random effect models, and ApaI C-allele with ESRD only under fixed effect model. Cochrane Q-test showed no evidence of heterogeneity for TaqI polymorphism and a significant heterogeneity for Apa I polymorphism. No publication bias was observed for both the polymorphisms. Conclusions The present meta-analysis identifies TaqI and ApaI polymorphisms of VDR gene as risk factors for renal diseases.

scholarly journals Apa I polymorphism in the vitamin D receptor gene may affect the parathyroid response in Japanese with end-stage renal disease

1998 ◽  
Vol 53 (2) ◽  
pp. 454-458 ◽  
Author(s):  
Keitaro Yokoyama ◽  
Takashi Shigematsu ◽  
Toshihiko Tsukada ◽  
Yousuke Ogura ◽  
Fumi Takemoto ◽  
...  
Keyword(s):  
Vitamin D ◽  
Renal Disease ◽  
Vitamin D Receptor ◽  
End Stage Renal Disease ◽  
Receptor Gene ◽  
Vitamin D Receptor Gene ◽  
Stage Renal Disease ◽  
End Stage

scholarly journals Vitamin D receptor genetic variants among patients with end-stage renal disease

Renal Failure ◽  
2010 ◽  
Vol 32 (8) ◽  
pp. 969-977 ◽  
Author(s):  
Gaurav Tripathi ◽  
Richa Sharma ◽  
Raj K. Sharma ◽  
Sushil Kumar Gupta ◽  
Satya Narayan Sankhwar ◽  
...  
Keyword(s):  
Vitamin D ◽  
Renal Disease ◽  
Vitamin D Receptor ◽  
Genetic Variants ◽  
End Stage Renal Disease ◽  
Stage Renal Disease ◽  
End Stage

scholarly journals Parathyroid Hormone Status in Patients with End Stage Renal Disease on Maintenance Haemodialysis

2014 ◽  
Vol 4 (1) ◽  
pp. 13-17
Author(s):  
SM Sajjad ◽  
YA Zaman ◽  
MA Rahim ◽  
A Mahmuda ◽  
WMM Haque ◽  
...  
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Calcium Phosphate ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Maintenance Haemodialysis ◽  
Stage Renal Disease ◽  
End Stage ◽  
Esrd Patients ◽  
Pth Level

Objective: To evaluate parathyroid hormone (PTH) status among end stage renal disease (ESRD) patients on maintenance haemodialysis (MHD). Methodology: This descriptive cross-sectional study was done in the Department of Nephrology, BIRDEM General Hospital, Dhaka, from April to September 2011. Results: A total of 50 patients were included in this study with a 3:2 male predominance. Mean age was 54.6 (range 34-76) years. Mean duration of ESRD was 3.73 years. All the patients were diabetic and other common co-morbidities were hypertension (76%), dyslipidaemia (56%), ischaemic heart disease (48%) and stroke (12%). They were receiving calcium (72%), vitamin D (40%), both calcium and vitamin D (38%) supplementation and 20% were not on any medication for treatment of chronic kidney disease mineral bone disorder (CKD-MBD). Mean pre-dialysis values of urea and creatinine were 30.28 mg/dl and 8.67 mg/dl respectively. Mean (± SD) serum level of calcium, phosphate and PTH were 8.32 (±1.26) mg/dl, 4.42 (±1.54) mg/dl and 125.45±117.71 pg/ml respectively. In 76% of the study subjects, PTH level was above normal. Significant difference (P=<0.05) in PTH levels was observed among patients with and without any medication for prevention of CKD-MBD but the levels were within the acceptable range. Serum calcium level in the study subjects had significant positive relationship with serum PTH level. It was also observed that PTH level had significant negative relationship with phosphate level. Conclusion: PTH level was higher in ESRD patients on MHD specially those who were not on any medication than those who took calcium, vitamin D or both but it was still within the acceptable reference range. In such patients, serum calcium, phosphate and PTH levels should be monitored periodically. DOI: http://dx.doi.org/10.3329/birdem.v4i1.18547 Birdem Med J 2014; 4(1): 13-17

scholarly journals Levels of vitamin D receptor and CYP24A1 in patients with end-stage renal disease

2016 ◽  
Vol 16 (2) ◽  
pp. 462 ◽  
Author(s):  
Jia-Jun Ye ◽  
Tian-Biao Zhou ◽  
Yun-Fang Zhang ◽  
Qi Wang ◽  
Yan-Yan Su ◽  
...  
Keyword(s):  
Vitamin D ◽  
Renal Disease ◽  
Vitamin D Receptor ◽  
End Stage Renal Disease ◽  
Stage Renal Disease ◽  
End Stage

scholarly journals The Influence of −174 G/C Interleukin 6 Promoter Gene Polymorphism to Interleukin 6 Concentration in the End Stage Renal Disease Patients with Dialysis: A Single-center Experience in Indonesia

2020 ◽  
Vol 8 (A) ◽  
pp. 563-566
Author(s):  
Riri Andri Muzasti ◽  
Herman Hariman ◽  
Elvita Rahmi Daulay
Keyword(s):  
Kidney Disease ◽  
Gene Polymorphism ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Promoter Region ◽  
Pcr Rflp ◽  
Promoter Gene ◽  
Stage Renal Disease ◽  
End Stage ◽  
Esrd Patients

BACKGROUND: Chronic kidney disease (CKD) is classified as a multifactorial disease as a combination of genetic and environmental factors that affect the onset and progression of end-stage renal disease (ESRD). In the last decades are recognized that inflammation, where the critical modulator is cytokines, can occur before the onset of kidney disease and can be a causative factor in the development of CKD. Interleukin (IL)-6 has several polymorphisms in the promoter region, such as 174 G-C, 634 C-G, 572 G-C, and 597 G-A. G/C single nucleotide polymorphism of the IL-6 gene at position 174 in the promoter region is reported to affect the level of IL-6 expression. Unfortunately, there is a lack of data about the genotype frequencies of -174 G/C IL-6 promoter gene polymorphism in Indonesian with ESRD. AIM: This study aimed to analyze whether −174 G/C IL-6 promoter gene polymorphism influences the concentration of IL-6 in ESRD patients with dialysis in Indonesia. METHODS: We recruited 95 outpatients who were undergoing regular hemodialysis for ≥3 months at the Rasyida Renal Hospital, Medan, in this cross-sectional study. IL-6 genotype polymorphism was analyzed using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. The enzyme-linked immunosorbent assay method was performed to assess the quantitative IL-6 serum. RESULTS: PCR-RFLP examination showed the frequency distribution of the IL-6 genotype -174 G/C gene; 72 (75.8%) respondents had GG genotypes; 22.1% of respondents had the CG genotype, and (2.1%) had the CC genotypes. Patients with the CC genotype were statistically significant to have higher IL-6 concentration compared to other genotypes (p < 0.001). Likewise, with diabetic patients, statistics showed higher IL-6 concentration compared to non-diabetics patients (p < 0.001). CONCLUSION: This is the first study showing that -174 G/C IL-6 promoter gene polymorphism influences the IL-6 concentrations in ESRD patients with dialysis in Indonesia. Multicenter studies are needed to validate these findings.

scholarly journals Association of Vitamin D Receptor TaqI and ApaI Genetic Polymorphisms with Nephrolithiasis and End Stage Renal Disease: A Meta-Analysis and an Investigation into Latitudinal Effect on Disease Penetrance

2019 ◽  
Author(s):  
Tajamul Hussain ◽  
Shaik M. Naushad ◽  
Anwar Ahmed ◽  
Salman Alamery ◽  
Arif A. Mohammed ◽  
...  
Keyword(s):  
Vitamin D ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Disease Risk ◽  
Meta Analysis ◽  
Renal Diseases ◽  
Vdr Gene ◽  
Disease Penetrance ◽  
Stage Renal Disease ◽  
End Stage

Abstract Background: The deficiency of vitamin D receptor (VDR) or its ligand, vitamin D3, is linked to the development of renal diseases. The TaqI (rs731236) and ApaI (rs7975232) polymorphisms of VDR gene are widely studied for their association with renal disease risk. However, studies have largely been ambiguous. Objectives: Here, a meta-analysis comprising 2669 renal disease cases and 3342 controls was carried out to clarify the association of TaqI and ApaI polymorphisms with nephrolithiasis (NL), diabetic nephropathy (DN) and end stage renal disease (ESRD). Methods and Results: The VDR TaqI C-allele under allele contrast and fixed effect models was significantly associated with NL and ESRD, and Apal T-allele with ESRD only under fixed effect model. Cochrane Q-test showed no evidence of heterogeneity for TaqI polymorphism and a significant heterogeneity for Apa I polymorphism. No publication bias was observed for both the polymorphisms. Interestingly, increased disease penetrance with an increase in latitude from south to north across the globe was found only in the case of Taql polymorphism but not with Apal. Conclusions and Implications: The present meta-analysis identifies TaqI and ApaI polymorphisms of VDR gene as significant risk factors for renal diseases. Besides, increased disease penetrance with Taql polymorphism from south to north may corroborate with combined effect of defective VDR expression and decreased vitamin D synthesis due shorter durations of sun exposure with increasing latitude. On the other hand, possibility of Apal polymorphism in linkage disequilibrium with an adjacent functional polymorphism and lack of their co-segregation may have resulted in reduced disease penetrance. Present findings may have implications in understanding the role of gene-environmental interaction in renal disease risk.

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