The relation of plasma total homocysteine levels to prevalent cardiovascular disease in older patients with ischemic stroke

2000 ◽  
Vol 12 (1) ◽  
pp. 48-52 ◽  
Author(s):  
A. Adunsky ◽  
A. Weitzman ◽  
Y. Fleissig ◽  
L. Levenkrohn ◽  
M. Arad ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Ischemic Stroke ◽  
Older Patients ◽  
Total Homocysteine ◽  
Plasma Total Homocysteine

Assessing Plasma Total Homocysteine in Patients with End-Stage Renal Disease

2007 ◽  
Vol 27 (5) ◽  
pp. 476-488 ◽  
Author(s):  
Bradley L. Urquhart ◽  
Andrew A. House
Keyword(s):  
Cardiovascular Disease ◽  
Risk Factor ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Elevated Plasma ◽  
Plasma Thcy ◽  
Total Homocysteine ◽  
Stage Renal Disease ◽  
End Stage ◽  
Plasma Total Homocysteine

Elevated plasma total homocysteine (tHcy) is a risk factor for cardiovascular disease; however, in light of several recent randomized trials, the issue of causality has been cast into doubt. Patients with end-stage renal disease are particularly interesting as they consistently have elevated tHcy and their leading causes of morbidity and mortality are related to cardiovascular disease. In the present article, we review the early evidence for the homocysteine theory of atherosclerosis, homocysteine metabolism, mechanisms of toxicity, and pertinent available clinical investigations. Where appropriate, the sparse evidence of homocysteine in peritoneal dialysis is reviewed. We conclude by addressing the difficulties associated with lowering plasma tHcy in patients with end-stage renal disease and suggest some novel methods for lowering tHcy in this resistant population. Finally, to address the issue of causality, we recommend that clinicians and scientists await the results of the FAVORIT trial before abandoning homocysteine as a modifiable risk factor for cardiovascular disease, as this study has recruited patients from a population with consistently elevated plasma tHcy who are known to respond to vitamin therapy.

Plasma Total Homocysteine and Hospitalizations for Cardiovascular Disease

2002 ◽  
Vol 162 (12) ◽  
pp. 1374 ◽  
Author(s):  
Eha Nurk ◽  
Grethe S. Tell ◽  
Stein Emil Vollset ◽  
Ottar Nygård ◽  
Helga Refsum ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Total Homocysteine ◽  
Plasma Total Homocysteine

scholarly journals The risk association of plasma total homocysteine with acute myocardial infarction is modified by serum vitamin A

2018 ◽  
Vol 25 (15) ◽  
pp. 1612-1620 ◽  
Author(s):  
Thomas Olsen ◽  
Kathrine J Vinknes ◽  
Gard FT Svingen ◽  
Eva R Pedersen ◽  
Indu Dhar ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Cardiovascular Disease ◽  
Acute Myocardial Infarction ◽  
Standard Deviation ◽  
Angina Pectoris ◽  
Stable Angina ◽  
Stable Angina Pectoris ◽  
Plasma Thcy ◽  
Total Homocysteine ◽  
Plasma Total Homocysteine

Background Plasma total homocysteine (tHcy) has been implicated in the development of cardiovascular disease, but the mechanisms remain unclear. Vitamin A (Vit-A) is involved in homocysteine metabolism and we therefore explored the potential interaction between plasma tHcy and serum Vit-A in relation to incident acute myocardial infarction. Methods Cox proportional hazards models were used to assess the prospective relationships between tHcy and acute myocardial infarction in 2205 patients from Western Norway undergoing elective coronary angiography for suspected stable angina pectoris. Results are reported as hazard ratio per standard deviation increase in log-transformed tHcy. An interaction term for tHcy × Vit-A was added to multivariate models including age, sex, smoking, apolipoprotein B fasting, statin and aspirin prescription and estimated glomerular filtration rate. Results Geometric mean (geometric standard deviation) age of the participants (64.3% men) was 62.3 (1.24) years. Plasma tHcy was higher among participants in the upper versus lower Vit-A tertile. During 7 (2.4) years of follow-up, 15.1% suffered an AMI. A significant association of plasma tHcy with AMI in the total study population was observed. When we stratified the population according to Vit-A tertiles, plasma tHcy was associated with acute myocardial infarction only in the upper Vit-A tertile (hazard ratio per SD: 1.25, 95% confidence interval: 1.04–1.53, pinteraction = 0.03). Conclusions The risk relationship between plasma tHcy and acute myocardial infarction was modified by serum concentrations of Vit-A in patients with suspected stable angina pectoris. This finding may clarify the relationship between tHcy and cardiovascular disease.

scholarly journals Nonfasting Plasma Total Homocysteine Levels and All-Cause and Cardiovascular Disease Mortality in Elderly Framingham Men and Women

1999 ◽  
Vol 159 (10) ◽  
pp. 1077 ◽  
Author(s):  
Andrew G. Bostom ◽  
Halit Silbershatz ◽  
Irwin H. Rosenberg ◽  
Jacob Selhub ◽  
Ralph B. D'Agostino ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Men And Women ◽  
Cardiovascular Disease Mortality ◽  
Disease Mortality ◽  
Total Homocysteine ◽  
Plasma Total Homocysteine

The effect of polymorphisms of MTHFR C677T, A1298C, MS A2756G and CBS 844ins68bp on plasma total homocysteine level and the risk of ischemic stroke in Thai children

2008 ◽  
Vol 122 (1) ◽  
pp. 33-37 ◽  
Author(s):  
Nongnuch Sirachainan ◽  
Werasak Sasanakul ◽  
Anannit Visudtibhan ◽  
Pornsri Tapanapruksakul ◽  
Pimlak Charoenkwan ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Homocysteine Level ◽  
Mthfr C677t ◽  
Total Homocysteine ◽  
Plasma Total Homocysteine ◽  
Ms A2756g
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