Parathyroid hormone regulates osterix and Runx2 mRNA expression predominantly through protein kinase A signaling in osteoblast-like cells

2006 ◽  
Vol 29 (2) ◽  
pp. 101-108 ◽  
Author(s):  
B. L. Wang ◽  
C. L. Dai ◽  
J. X. Quan ◽  
Z. F. Zhu ◽  
F. Zheng ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Protein Kinase ◽  
Mrna Expression ◽  
Protein Kinase A ◽  
Kinase A

Involvement of protein kinase A in histamine-mediated inhibition of IL-2 mRNA expression in mouse splenocytes

1999 ◽  
Vol 41 (2) ◽  
pp. 77-87 ◽  
Author(s):  
Larisa Y. Poluektova ◽  
Gregory K. Huggler ◽  
Eric B. Patterson ◽  
Manzoor M. Khan
Keyword(s):  
Protein Kinase ◽  
Mrna Expression ◽  
Protein Kinase A ◽  
Mouse Splenocytes ◽  
Kinase A

scholarly journals Parathyroid hormone-related peptide regulation of chick tibial growth plate chondrocyte maturation requires protein kinase A

2002 ◽  
Vol 20 (5) ◽  
pp. 1079-1090 ◽  
Author(s):  
Michael J. Zuscik ◽  
Regis J. O'Keefe ◽  
Thomas E. Gunter ◽  
J. Edward Puzas ◽  
Edward M. Schwarz ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Protein Kinase ◽  
Protein Kinase A ◽  
Growth Plate ◽  
Chondrocyte Maturation ◽  
Related Peptide ◽  
Growth Plate Chondrocyte ◽  
Parathyroid Hormone Related Peptide ◽  
Tibial Growth Plate ◽  
Kinase A

Regulation of arginine vasopressin mRNA in rat fetal hypothalamic cell culture. Role of protein kinases and glucocorticoids

1993 ◽  
Vol 10 (1) ◽  
pp. 51-57 ◽  
Author(s):  
S-B Hu ◽  
L A Tannahill ◽  
S L Lightman
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Mrna Expression ◽  
Protein Kinase A ◽  
Arginine Vasopressin ◽  
In Situ Hybridization Histochemistry ◽  
Kinase C ◽  
Kinase A

ABSTRACT Studies have been performed to investigate the regulation of arginine vasopressin (AVP) mRNA expression in fetal hypothalamic cultures. AVP mRNA-positive neurones were identified by in-situ hybridization histochemistry, and changes in mRNA expression were quantitated by nuclease protection assay. Both protein kinase C and protein kinase A activators increased the expression of AVP mRNA, in contrast to dexamethasone, which inhibited the responses to both protein kinase C and protein kinase A activation.

Inhibition of PAH transport by parathyroid hormone in OK cells: involvement of protein kinase C pathway

1997 ◽  
Vol 273 (5) ◽  
pp. F674-F679 ◽  
Author(s):  
Junya Nagai ◽  
Ikuko Yano ◽  
Yukiya Hashimoto ◽  
Mikihisa Takano ◽  
Ken-Ichi Inui
Keyword(s):  
Protein Kinase C ◽  
Parathyroid Hormone ◽  
Protein Kinase ◽  
Protein Kinase A ◽  
Regulatory Control ◽  
Dependent Manner ◽  
Transcellular Transport ◽  
Ok Cells ◽  
Kinase C ◽  
Kinase A

We have previously shown that the p-aminohippurate (PAH) transport system in OK kidney epithelial cell line is under the regulatory control of protein kinase C. Parathyroid hormone (PTH) could activate protein kinase C, as well as protein kinase A, in OK cells. In the present study, the effect of PTH on PAH transport was studied in OK cells. PTH inhibited the transcellular transport of PAH from the basal to the apical side, as well as the accumulation of PAH in OK cells. Basolateral PAH uptake was inhibited by PTH in a dose- and time-dependent manner. Protein kinase A activators did not affect the transcellular transport or the accumulation of PAH. The PTH-induced inhibition of the accumulation of PAH was blocked by a protein kinase C inhibitor staurosporine. These results suggest that PTH inhibits the PAH transport in OK cells and that the messenger system mediated by protein kinase C, not protein kinase A, plays an important role in the regulation of PAH transport by PTH.

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