Hexarelin, a synthetic GH-releasing peptide, is a powerful stimulus of GH secretion in pubertal children and in adults but not in prepubertal children and in elderly subjects

1998 ◽  
Vol 21 (8) ◽  
pp. 494-500 ◽  
Author(s):  
J. Bellone ◽  
E. Bartolotta ◽  
C. Sgattoni ◽  
G. Aimaretti ◽  
E. Arvat ◽  
...  
Keyword(s):  
Elderly Subjects ◽  
Prepubertal Children ◽  
Gh Secretion ◽  
Powerful Stimulus

Effects of an Acetylcholine Precursor on GH Secretion in Elderly Subjects

1994 ◽  
pp. 328-337
Author(s):  
Gian Paolo Ceda ◽  
Gian Piero Marzani ◽  
Valeria Tontodonati ◽  
Emanuela Piovani ◽  
Alberto Banchini ◽  
...  
Keyword(s):  
Elderly Subjects ◽  
Gh Secretion

scholarly journals Plasma ghrelin concentrations in elderly subjects: comparison with anorexic and obese patients

2002 ◽  
Vol 175 (1) ◽  
pp. R1-R5 ◽  
Author(s):  
AE Rigamonti ◽  
AI Pincelli ◽  
B Corra ◽  
R Viarengo ◽  
SM Bonomo ◽  
...  
Keyword(s):  
Food Intake ◽  
Serum Insulin ◽  
Normal Weight ◽  
Elderly Subjects ◽  
Baseline Serum ◽  
Insulin Levels ◽  
Gh Secretion ◽  
Fasting Plasma ◽  
Age Related ◽  
Igf I

Ghrelin, a novel endogenous ligand for the GH secretagogue receptor, has been reported to stimulate GH secretion and food intake in both humans and other animals. Interestingly, recent data indicate that ghrelin is up- and down-regulated in anorexia nervosa (AN) and obesity, which are also known to be accompanied by increased and reduced GH levels respectively. Ageing is associated with a gradual but progressive reduction in GH secretion, and by alterations in appetite and food intake. The role of ghrelin in the decline of somatotroph function and the anorexia of ageing is unknown. To investigate the influence of age on circulating levels of ghrelin, a total of 19 young and old normal weight subjects (Y-NW, n=12; O-NW, n=7), six patients with active AN (A-AN), and seven patients with morbid obesity (OB) were studied. In addition to fasting plasma ghrelin concentrations, baseline serum TSH, IGF-I and insulin levels were measured. Mean plasma ghrelin concentrations in A-AN or OB were higher and lower respectively than those present in Y-NW. Interestingly, mean plasma ghrelin concentrations in O-NW were significantly lower than those present in Y-NW and superimposable on those of OB. The mean fasting plasma ghrelin concentrations in all groups of subjects were negatively correlated with body mass index and serum insulin levels, but not with TSH and IGF-I levels. This study provides evidence of an age-related decline of plasma ghrelin concentrations, which might explain, at least partially, the somatotroph dysregulation and the anorexia of the elderly subject.

scholarly journals Leptin, Cortisol, and GH Secretion Interactions in Short Normal Prepubertal Children

2001 ◽  
Vol 86 (8) ◽  
pp. 3729-3734 ◽  
Author(s):  
Lucia Ghizzoni ◽  
George Mastorakos ◽  
Maria E. Street ◽  
Gemma Mazzardo ◽  
Alessandra Vottero ◽  
...  
Keyword(s):  
Prepubertal Children ◽  
Gh Secretion

Reproducibility of 24-h growth hormone profiles in children

1992 ◽  
Vol 126 (2) ◽  
pp. 109-112 ◽  
Author(s):  
Kerstin Albertsson-Wikland ◽  
Sten Rosberg
Keyword(s):  
Time Interval ◽  
Individual Child ◽  
High Reproducibility ◽  
Normal Height ◽  
Prepubertal Children ◽  
Gh Secretion ◽  
Biological Phenomena ◽  
High Degree ◽  
Mean Time ◽  
Peak Widths

The rate of GH secretion and the pattern of GH peaks were compared in a group of nine prepubertal children during their prepubertal period in repeated 24-h GH profiles. At investigation, the children were 6–1 3 years old (at first profile 6–11 years old) and of normal height (±2 sd). Two profiles were obtained per child, (with a mean time interval of 1.5 years, range 0.7 to 3.5 years. The calculated GH secretions of the first and second profiles were compared. As a group, no significant differences in secreted amount of GH, when expressed as data from the second profile as a percentage of data from the first profile (93±8%), number of peaks (98±7%) or mean peak amplitudes (92±11%), were obtained. Between the repeated curves of an individual child, maximal difference in secretion, number of peaks and mean peak amplitudes ranged around±30%, with a mean intraindividual cv of 12%. The reproducibility in the peak distribution for all profiles was also analysed. The relative frequencies is a percentage of the GH peak amplitudes and peak widths were virtually identical in the repeated profiles. Reproducibility of the temporal pattern of profiles was analysed using time-series analysis (Fourier analysis) and showed no difference in rhythmicity between the different occasions. In conclusion, a high reproducibility of both GH secretion and GH pattern was found for the whole group of prepubertal children. The high degree of reproducibility of the 24-h GH profiles of the whole group of children indicated that the information from these curves, in terms of both pattern and total secretion, can be used for clinical as well as for physiological purposes. The intraindividual reproducibility was less pronounced, however, leading to a sound scepticism when relating biological phenomena to a single profile of an individual child.

Urinary GH Secretion Correlates with Plasma GH Levels during Sleep and GHRH Stimulation Tests but Not during the L-Dopa Stimulation Test in Prepubertal Children

1993 ◽  
Vol 39 (1-2) ◽  
pp. 19-24 ◽  
Author(s):  
D. Porguet ◽  
A. Fjellestad-Paulsen ◽  
J. Leger ◽  
D. Simon ◽  
P. Czernichow ◽  
...  
Keyword(s):  
Stimulation Test ◽  
Prepubertal Children ◽  
Gh Secretion ◽  
Stimulation Tests ◽  
Plasma Gh

Pyridostigmine partially restores the GH responsiveness to GHRH in normal aging

1990 ◽  
Vol 123 (2) ◽  
pp. 169-173 ◽  
Author(s):  
E. Ghigo ◽  
S. Goffi ◽  
E. Arvat ◽  
M. Nicolosi ◽  
M. Procopio ◽  
...  
Keyword(s):  
Normal Subjects ◽  
The Elderly ◽  
Normal Aging ◽  
Elderly Subjects ◽  
Plasma Growth Hormone ◽  
Gh Secretion ◽  
Combined Administration ◽  
Basal Plasma ◽  
Young Subjects ◽  
Plasma Gh

Abstract. In 11 elderly normal subjects and in 17 young healthy subjects we studied the response of plasma growth hormone to GH-releasing hormone (GHRH(29), 1 μg/kg iv) alone and preceded by pyridostigmine ( 120 mg orally 60 min before GHRH), a cholinesterase inhibitor likely able to suppress somatostatin release. The GH response to pyridostigmine alone was also examined. Basal plasma GH levels were similar in elderly and young subjects. In the elderly, GHRH induced a GH rise (AUC, median and range: 207.5, 43.5-444.0 μg · 1−1 · h−1) which was lower (p = 0.006) than that observed in young subjects (548.0, 112.5-2313.5 μg · 1−1 · h−1). The pyridostigmine-induced GH rise in the elderly was similar to that in young subjects (300.5, 163.0-470.0 vs 265.0, 33.0-514.5 μg · 1−1 · h−1). Pyridostigmine potentiated the GH responsiveness to GHRH in both elderly (437.5, 152.0-1815.5 μg · 1−1 · h−1; p = 0.01 vs GHRH alone) and young subjects (2140.0, 681.5-4429.5 μg · 1−1 · h−1; p = 0.0001 vs GHRH alone). However, the GH response to pyridostigmine + GHRH was significantly lower (p = 0.0001) in elderly than in young subjects. In conclusion, the cholinergic enhancement by pyridostigmine is able to potentiate the blunted GH response to GHRH in elderly subjects, inducing a GH increase similar to that observed after GHRH alone in young adults. This finding suggests that an alteration of somatostatinergic tone could be involved in the reduced GH secretion in normal aging. However, a decreased GH response to combined administration of pyridostigmine and GHRH in elderly subjects suggests that other abnormalities may coexist, leading to the secretory hypoactivity of somatotropes.

Direct Double Monoclonal Immunoradiometric Assay of Urinary Human Growth Hormone

1992 ◽  
Vol 38 (9) ◽  
pp. 1717-1721 ◽  
Author(s):  
D Porquet ◽  
O Rigal ◽  
D E Brion ◽  
F Valade ◽  
J Leger ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Human Growth ◽  
Sample Volume ◽  
Immunoradiometric Assay ◽  
Prepubertal Children ◽  
Gh Secretion ◽  
Analytical Recovery ◽  
Stimulation Tests ◽  
Normal Stature ◽  
Dilution Experiments

Abstract Several reports indicate that urinary growth hormone (GH) excretion might reflect central release of the hormone, and that measurement of urinary GH shows promise in the investigation of physiological and pathological GH secretion. We have developed and evaluated a direct immunoradiometric assay (IRMA) in which two monoclonal antibodies are used to measure GH in the urine of children. The detection limit is approximately 0.018 pmol/L for a sample volume of 2 mL. Within- and between-run variations (CVs) were 5.6% and 14.2%, respectively. Analytical recovery and dilution experiments showed the specificity of the method for GH. In normal-stature prepubertal children ages 3-12 years, 24-h urinary GH excretion was 0.189 (SD 0.100) pmol and correlated well with the amount of GH in the first morning miction, which showed wide day-to-day variations. Like others, we found a strong correlation between GH concentrations in serum and urine during stimulation tests with GH-releasing hormone (somatoliberin) and (or) during physiological nocturnal secretion, confirming that urinary GH measurement may be of help in investigating patients (particularly young children) with diseases in which GH secretion is impaired.

scholarly journals Prevalence of IGF1 deficiency in prepubertal children with isolated short stature

2009 ◽  
Vol 161 (1) ◽  
pp. 43-50 ◽  
Author(s):  
T Edouard ◽  
S Grünenwald ◽  
I Gennero ◽  
J P Salles ◽  
M Tauber
Keyword(s):  
Short Stature ◽  
Gestational Age ◽  
Bone Age ◽  
Pediatric Endocrinology ◽  
Exclusion Criteria ◽  
Prepubertal Children ◽  
Gh Secretion ◽  
Appropriate For Gestational Age ◽  
Low Levels ◽  
Igf1 Deficiency

Background/aims‘Primary IGF1 deficiency (IGFD)’ is defined by low levels of IGF1 without a concomitant impairment in GH secretion in the absence of secondary cause. The aims of this study were to evaluate the prevalence of non-GH deficient IGFD in prepubertal children with isolated short stature (SS) and to describe this population.MethodsThis retrospective study included all children with isolated SS seen in our Pediatric Endocrinology Unit from January 2005 to December 2007. Children were included based on the following criteria: i) SS with current height SDS ≤ −2.5, ii) age≥2 years, and iii) prepubertal status. Exclusion criteria were: i) identified cause of SS and ii) current or past therapy with rhGH. IGF1-deficient children were defined as children without GH deficiency and with IGF1 levels below or equal to −2 SDS.ResultsAmong 65 children with isolated SS, 13 (20%) had low IGF1 levels, consistent with a diagnosis of primary IGFD, four of which were born small for gestational age and nine were born appropriate for gestational age. When compared with non-IGFD children, IGFD children had higher birth weight (−0.7 vs −1 SDS, P=0.02) and birth height (−1.7 vs −2 SDS, P=0.04) and more delayed bone age (2.6 vs 1.7 years, P=0.03).ConclusionThe prevalence of primary IGFD was 20% in children with isolated SS. Concerning the pathophysiology, our study emphasizes that IGFD in some children may be secondary to nutritional deficiency or to maturational delay.

Measurement of Spontaneous, 12-Hour Sleep-Associated GH Secretion in Prepubertal Children with Short Stature: Clinical Relevance and Practicability?

1996 ◽  
Vol 46 (1) ◽  
pp. 33-37 ◽  
Author(s):  
H. Schmidt ◽  
H.G. Dörr ◽  
O. Butenandt ◽  
A. Galli-Tsinopoulou ◽  
W. Kiess
Keyword(s):  
Short Stature ◽  
Clinical Relevance ◽  
Prepubertal Children ◽  
Gh Secretion
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