scholarly journals Immunogenicity and In Vivo Efficacy of Recombinant Plasmodium falciparum Merozoite Surface Protein-1 in Aotus Monkeys

1995 ◽  
Vol 1 (3) ◽  
pp. 325-332 ◽  
Author(s):  
Sanjai Kumar ◽  
Anjali Yadava ◽  
David B. Keister ◽  
Jing Hui Tian ◽  
Michael Ohl ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Surface Protein ◽  
Merozoite Surface Protein ◽  
In Vivo Efficacy ◽  
Merozoite Surface Protein 1 ◽  
Falciparum Merozoite

IgG subclass antibodies to three variants of Plasmodium falciparum merozoite surface protein-1 (PfMSP-119) in an area with unstable malaria transmission in Iran

Acta Tropica ◽  
2011 ◽  
Vol 119 (2-3) ◽  
pp. 84-90 ◽  
Author(s):  
Akram Abouie Mehrizi ◽  
Sara Asgharpour ◽  
Ali-Hatef Salmanian ◽  
Navid Dinparast Djadid ◽  
Sedigheh Zakeri
Keyword(s):  
Plasmodium Falciparum ◽  
Malaria Transmission ◽  
Surface Protein ◽  
Merozoite Surface Protein ◽  
Igg Subclass ◽  
Merozoite Surface Protein 1 ◽  
Falciparum Merozoite

Analysis of sequence diversity in the Plasmodium falciparum merozoite surface protein-1 (MSP-1)

1993 ◽  
Vol 59 (1) ◽  
pp. 1-14 ◽  
Author(s):  
Louis H. Miller ◽  
Theodore Roberts ◽  
Mohammed Shahabuddin ◽  
Thomas F. McCutchan
Keyword(s):  
Plasmodium Falciparum ◽  
Surface Protein ◽  
Merozoite Surface Protein ◽  
Sequence Diversity ◽  
Merozoite Surface Protein 1 ◽  
Falciparum Merozoite

Solution structure of an EGF module pair from the Plasmodium falciparum merozoite surface protein 1 1 1Edited by P. E. Wright

1999 ◽  
Vol 289 (1) ◽  
pp. 113-122 ◽  
Author(s):  
William D. Morgan ◽  
Berry Birdsall ◽  
Thomas A. Frenkiel ◽  
Michael G. Gradwell ◽  
Petra A. Burghaus ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Solution Structure ◽  
Surface Protein ◽  
Merozoite Surface Protein ◽  
Merozoite Surface Protein 1 ◽  
Falciparum Merozoite

N-terminal amino acid sequence of the Plasmodium falciparum merozoite surface protein-1 polypeptides

1994 ◽  
Vol 66 (1) ◽  
pp. 157-160 ◽  
Author(s):  
William H.L. Stafford ◽  
Michael J. Blackman ◽  
Alan Harris ◽  
Shafrira Shai ◽  
Muni Grainger ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Amino Acid ◽  
Amino Acid Sequence ◽  
Surface Protein ◽  
Merozoite Surface Protein ◽  
Terminal Amino Acid ◽  
Merozoite Surface Protein 1 ◽  
Falciparum Merozoite ◽  
Terminal Amino ◽  
Terminal Amino Acid Sequence

scholarly journals Immunoglobulin G Subclass-Specific Responses against Plasmodium falciparum Merozoite Antigens Are Associated with Control of Parasitemia and Protection from Symptomatic Illness

2009 ◽  
Vol 77 (3) ◽  
pp. 1165-1174 ◽  
Author(s):  
Danielle I. Stanisic ◽  
Jack S. Richards ◽  
Fiona J. McCallum ◽  
Pascal Michon ◽  
Christopher L. King ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Immunoglobulin G ◽  
Vaccine Development ◽  
Surface Protein ◽  
Merozoite Surface Protein ◽  
Igg Subclass ◽  
Apical Membrane Antigen 1 ◽  
Falciparum Merozoite ◽  
Merozoite Antigens

ABSTRACT Substantial evidence indicates that antibodies to Plasmodium falciparum merozoite antigens play a role in protection from malaria, although the precise targets and mechanisms mediating immunity remain unclear. Different malaria antigens induce distinct immunoglobulin G (IgG) subclass responses, but the importance of different responses in protective immunity from malaria is not known and the factors determining subclass responses in vivo are poorly understood. We examined IgG and IgG subclass responses to the merozoite antigens MSP1-19 (the 19-kDa C-terminal region of merozoite surface protein 1), MSP2 (merozoite surface protein 2), and AMA-1 (apical membrane antigen 1), including different polymorphic variants of these antigens, in a longitudinal cohort of children in Papua New Guinea. IgG1 and IgG3 were the predominant subclasses of antibodies to each antigen, and all antibody responses increased in association with age and exposure without evidence of increasing polarization toward one subclass. The profiles of IgG subclasses differed somewhat for different alleles of MSP2 but not for different variants of AMA-1. Individuals did not appear to have a propensity to make a specific subclass response irrespective of the antigen. Instead, data suggest that subclass responses to each antigen are generated independently among individuals and that antigen properties, rather than host factors, are the major determinants of IgG subclass responses. High levels of AMA-1-specific IgG3 and MSP1-19-specific IgG1 were strongly predictive of a reduced risk of symptomatic malaria and high-density P. falciparum infections. However, no antibody response was significantly associated with protection from parasitization per se. Our findings have major implications for understanding human immunity and for malaria vaccine development and evaluation.

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