Designing RNA folding cooperativity

2008 ◽  
pp. 56-61
Author(s):  
Eivind Tøstesen ◽  
Shi-Jie Chen ◽  
Ken A. Dill
Keyword(s):  
Rna Folding

Transcription regulation through nascent RNA folding

2021 ◽  
pp. 166975
Author(s):  
Leonard Schärfen ◽  
Karla M. Neugebauer
Keyword(s):  
Transcription Regulation ◽  
Rna Folding ◽  
Nascent Rna

scholarly journals Hinge Stiffness Is a Barrier to RNA Folding

2008 ◽  
Vol 379 (4) ◽  
pp. 859-870 ◽  
Author(s):  
Jörg C. Schlatterer ◽  
Lisa W. Kwok ◽  
Jessica S. Lamb ◽  
Hye Yoon Park ◽  
Kurt Andresen ◽  
...  
Keyword(s):  
Rna Folding

Tertiary RNA Folding-Targeted Drug Screening Strategy Using a Protein Nanopore

2021 ◽  
Vol 93 (5) ◽  
pp. 2811-2819
Author(s):  
Dong-Hwa Lee ◽  
Sohee Oh ◽  
Kyungeun Lim ◽  
Boah Lee ◽  
Gwan-Su Yi ◽  
...  
Keyword(s):  
Drug Screening ◽  
Rna Folding ◽  
Screening Strategy ◽  
Targeted Drug

scholarly journals Conserved long-range base pairings are associated with pre-mRNA processing of human genes

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Svetlana Kalmykova ◽  
Marina Kalinina ◽  
Stepan Denisov ◽  
Alexey Mironov ◽  
Dmitry Skvortsov ◽  
...  
Keyword(s):  
Long Range ◽  
Rna Folding ◽  
Current Knowledge ◽  
Rna Structures ◽  
Base Pairs ◽  
Protein Coding ◽  
Proximity Ligation ◽  
Transcriptional Suppression ◽  
Human Genes ◽  
Cleavage And Polyadenylation

AbstractThe ability of nucleic acids to form double-stranded structures is essential for all living systems on Earth. Current knowledge on functional RNA structures is focused on locally-occurring base pairs. However, crosslinking and proximity ligation experiments demonstrated that long-range RNA structures are highly abundant. Here, we present the most complete to-date catalog of conserved complementary regions (PCCRs) in human protein-coding genes. PCCRs tend to occur within introns, suppress intervening exons, and obstruct cryptic and inactive splice sites. Double-stranded structure of PCCRs is supported by decreased icSHAPE nucleotide accessibility, high abundance of RNA editing sites, and frequent occurrence of forked eCLIP peaks. Introns with PCCRs show a distinct splicing pattern in response to RNAPII slowdown suggesting that splicing is widely affected by co-transcriptional RNA folding. The enrichment of 3’-ends within PCCRs raises the intriguing hypothesis that coupling between RNA folding and splicing could mediate co-transcriptional suppression of premature pre-mRNA cleavage and polyadenylation.

Functional Roles of Chelated Magnesium Ions in RNA Folding and Function

Biochemistry ◽  
2021 ◽  
Author(s):  
Ryota Yamagami ◽  
Jacob P. Sieg ◽  
Philip C. Bevilacqua
Keyword(s):  
Rna Folding ◽  
Magnesium Ions ◽  
Functional Roles ◽  
And Function
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