Regulatory network of miRNA on its target: coordination between transcriptional and post-transcriptional regulation of gene expression

2018 ◽  
Vol 76 (3) ◽  
pp. 441-451 ◽  
Author(s):  
Mengfan Pu ◽  
Jing Chen ◽  
Zhouteng Tao ◽  
Lingling Miao ◽  
Xinming Qi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Transcriptional Regulation ◽  
Regulatory Network ◽  
Regulation Of Gene Expression ◽  
Post Transcriptional Regulation

scholarly journals The architecture of the human RNA-binding protein regulatory network

2016 ◽  
Author(s):  
Alessandro Quattrone ◽  
Erik Dassi
Keyword(s):  
Gene Expression ◽  
Transcriptional Regulation ◽  
Regulatory Network ◽  
Rna Binding ◽  
Rna Binding Proteins ◽  
Regulation Of Gene Expression ◽  
Hierarchical Structures ◽  
Systematic Investigation ◽  
Regulatory Structure ◽  
Post Transcriptional Regulation

AbstractRNA-binding proteins (RBPs) are key players of post-transcriptional regulation of gene expression. These proteins influence both cellular physiology and pathology by regulating processes ranging from splicing and polyadenylation to mRNA localization, stability, and translation. To fine-tune the outcome of their regulatory action, RBPs rely on an intricate web of competitive and cooperative interactions. Several studies have described individual interactions of RBPs with RBP mRNAs, suggestive of a RBP-RBP regulatory structure. Here we present the first systematic investigation of this structure, based on a network including almost fifty thousand experimentally determined interactions between RBPs and bound RBP mRNAs.Our analysis identified two features defining the structure of the RBP-RBP regulatory network. What we call “RBP clusters” are groups of densely interconnected RBPs which co-regulate their targets, suggesting a tight control of cooperative and competitive behaviors. “RBP chains”, instead, are hierarchical structures driven by evolutionarily ancient RBPs, which connect the RBP clusters and could in this way provide the flexibility to coordinate the tuning of a broad set of biological processes.The combination of these two features suggests that RBP chains may use the modulation of their RBP targets to coordinately control the different cell programs controlled by the RBP clusters. Under this island-hopping model, the regulatory signal flowing through the chains hops from one RBP cluster to another, implementing elaborate regulatory plans to impact cellular phenotypes. This work thus establishes RBP-RBP interactions as a backbone driving post-transcriptional regulation of gene expression to allow the fine-grained control of RBPs and their targets.

Post-transcriptional regulation of gene expression in hippocampal neurons by glutamate receptor activation

1995 ◽  
Vol 693 (1-2) ◽  
pp. 124-132 ◽  
Author(s):  
Emma R. Jakoi ◽  
David M. Panchision ◽  
Claudia M. Gerwin ◽  
Robert J. DeLorenzo
Keyword(s):  
Gene Expression ◽  
Transcriptional Regulation ◽  
Glutamate Receptor ◽  
Hippocampal Neurons ◽  
Regulation Of Gene Expression ◽  
Receptor Activation ◽  
Post Transcriptional Regulation

Post-transcriptional regulation of gene expression

Methods ◽  
2017 ◽  
Vol 126 ◽  
pp. 1-2 ◽  
Author(s):  
Howard D. Lipshitz ◽  
Julie M. Claycomb ◽  
Craig A. Smibert
Keyword(s):  
Gene Expression ◽  
Transcriptional Regulation ◽  
Regulation Of Gene Expression ◽  
Post Transcriptional Regulation

Transcriptional and post-transcriptional regulation of gene expression in developing barley endosperm

1989 ◽  
Vol 217 (2-3) ◽  
Author(s):  
Mikael Blom Sørensen ◽  
Verena Cameron-Mills ◽  
Anders Brandt
Keyword(s):  
Gene Expression ◽  
Transcriptional Regulation ◽  
Regulation Of Gene Expression ◽  
Barley Endosperm ◽  
Post Transcriptional Regulation

scholarly journals Post-transcriptional regulation of gene expression by degradation of messenger RNAs

2003 ◽  
Vol 195 (3) ◽  
pp. 356-372 ◽  
Author(s):  
Annamaria Bevilacqua ◽  
Maria Cristina Ceriani ◽  
Sergio Capaccioli ◽  
Angelo Nicolin
Keyword(s):  
Gene Expression ◽  
Transcriptional Regulation ◽  
Regulation Of Gene Expression ◽  
Messenger Rnas ◽  
Post Transcriptional Regulation
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