Synthesis, characterization, antimicrobial, and DNA cleavage studies of metal complexes of coumarin Schiff bases

2010 ◽  
Vol 20 (4) ◽  
pp. 493-502 ◽  
Author(s):  
Mohammedshafi A. Phaniband ◽  
Shreedhar D. Dhumwad ◽  
Shashikanth R. Pattan
Keyword(s):  
Metal Complexes ◽  
Schiff Bases ◽  
Dna Cleavage

scholarly journals DNA Cleavage, Cytotoxic Activities, and Antimicrobial Studies of Ternary Copper(II) Complexes of Isoxazole Schiff Base and Heterocyclic Compounds

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Vijay Kumar Chityala ◽  
K. Sathish Kumar ◽  
Ramesh Macha ◽  
Parthasarathy Tigulla ◽  
Shivaraj
Keyword(s):  
Antitumor Activity ◽  
Metal Complexes ◽  
Schiff Bases ◽  
Dna Cleavage ◽  
Spectral Studies ◽  
Planar Geometry ◽  
Cytotoxic Activities ◽  
Significant Activity ◽  
Antimicrobial Studies ◽  
Hela Cell Lines

Novel mixed ligand bivalent copper complexes [Cu. L. A. ClO4] and [Cu. L. A] where “L” is Schiff bases, namely 2-((3,4-dimethylisoxazol-5-ylimino)methyl)-4-bromophenol (DMIIMBP)/2-((3,4-dimethylisoxazol-5-ylimino)methyl)-4-chlorophenol (DMIIMCP), and “A” is heterocyclic compound, such as 1,10-phenanthroline (phen)/2,21-bipyridyl (bipy)/8-hydroxyquinoline (oxine)/5-chloro-8-hydroxyquinoline (5-Cl-oxine), have been synthesized. These complexes have been characterized by IR, UV-Vis, ESR, elemental analysis, magnetic moments, TG, and DTA. On the basis of spectral studies and analytical data, five-coordinated square pyramidal/four-coordinated square planar geometry is assigned to all complexes. The ligands and their ternary complexes with Cu(II) have been screened for antimicrobial activity against bacteria and fungi by paper disc method. The antimicrobial studies of Schiff bases and their metal complexes showed significant activity and further it is observed that the metal complexes showed more activity than corresponding Schiff bases. In vitro antitumor activity of Cu(II) complexes was assayed against human cervical carcinoma (HeLa) cancer cells and it was observed that few complexes exhibit good antitumor activity on HeLa cell lines. The DNA cleavage studies have also been carried out on pBR 322 and it is observed that these Cu(II) complexes are capable of cleaving supercoiled plasmid DNA in the presence of H2O2and UV light.

DNA cleavage mechanism by metal complexes of Cu(II), Zn(II) and VO(IV) with a schiff-base ligand

Biochimie ◽  
2021 ◽  
Vol 186 ◽  
pp. 43-50
Author(s):  
María R. Rodríguez ◽  
Martín J. Lavecchia ◽  
Beatriz S. Parajón-Costa ◽  
Ana C. González-Baró ◽  
María R. González-Baró ◽  
...  
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Schiff Base Ligand ◽  
Dna Cleavage

Synthesis, structural characterisation, bio-potential efficiency and DNA cleavage applications of nicotinamide metal complexes

2013 ◽  
Vol 1040 ◽  
pp. 192-205 ◽  
Author(s):  
C. Surendra Dilip ◽  
V. Siva Kumar ◽  
S. John Venison ◽  
I. Vetha potheher ◽  
D. Rajalaxmi (a) Subahashini
Keyword(s):  
Metal Complexes ◽  
Dna Cleavage ◽  
Structural Characterisation ◽  
Potential Efficiency

Metal complexes as ligands. VII. Copper bromide complexes with bidentate schiff bases

1969 ◽  
Vol 3 ◽  
pp. 81-86 ◽  
Author(s):  
C.M. Harris ◽  
P.J. Milham ◽  
J.M. James ◽  
E. Sinn
Keyword(s):  
Metal Complexes ◽  
Schiff Bases ◽  
Copper Bromide
Sign in / Sign up

Export Citation Format

Share Document