scholarly journals Synthesis, Characterization and Antimicrobial Activity of some Metal Complexes Derived from Thiazole Schiff Bases with In-vitro Cytotoxicity and DNA Cleavage Studies

2017 ◽  
Vol 51 (3) ◽  
pp. 490-501 ◽  
Author(s):  
Shambuling Karabasannavar ◽  
Parvati Allolli ◽  
Irfan N. Shaikh ◽  
Basavaraj M. Kalshetty
Keyword(s):  
Antimicrobial Activity ◽  
Metal Complexes ◽  
Schiff Bases ◽  
Dna Cleavage ◽  
In Vitro Cytotoxicity

scholarly journals Synthesis, Characterisation, Antimicrobial activity and DNA Cleavage of (E)-2-((Tetrazolo[1,5-A]Quinolin-4- ylmethylene)Amino)Phenol Schiff base Metal complexes

2020 ◽  
Vol 13 (2) ◽  
pp. 29-37
Author(s):  
Anilkumar Ambala ◽  
Ch. Abraham Lincoln
Keyword(s):  
Antimicrobial Activity ◽  
Schiff Base ◽  
Metal Complexes ◽  
Dna Cleavage ◽  
Analytical Data ◽  
Amino Phenol ◽  
Ft Ir ◽  
Uv Visible ◽  
Schiff Base Metal Complexes

A series of novel (E)-2-((Tetrazolo[1,5-a]quinolin-4-ylmethylene)amino)phenol Cu(II), Co(II), Ni(II), Zn(II) and Mn (II) metal complexes have been synthesized 1:1 metal to ligand ratio, and these complexes were characterized by using analytical data such as FT-IR, UV-visible, Mass spectroscopy, SEM, EDX, TGA and magnetic moment measurements. The ligand and all the metal complexes were tested in vitro antimicrobial activity and DNA cleavage studies.

scholarly journals Parent and nano-encapsulated ytterbium(iii) complex toward binding with biological macromolecules, in vitro cytotoxicity, cleavage and antimicrobial activity studies

RSC Advances ◽  
2020 ◽  
Vol 10 (39) ◽  
pp. 23002-23015 ◽  
Author(s):  
Zahra Aramesh-Boroujeni ◽  
Shohreh Jahani ◽  
Mozhgan Khorasani-Motlagh ◽  
Kagan Kerman ◽  
Meissam Noroozifar
Keyword(s):  
Antimicrobial Activity ◽  
Dna Cleavage ◽  
In Vitro Cytotoxicity ◽  
Biological Macromolecules ◽  
Biological Applications

The biological applications of Yb-complexes including anticancer, antimicrobial and DNA cleavage ability, and their interaction with FS-DNA and BSA were examined.

Synthesis, characterization, antimicrobial, and DNA cleavage studies of metal complexes of coumarin Schiff bases

2010 ◽  
Vol 20 (4) ◽  
pp. 493-502 ◽  
Author(s):  
Mohammedshafi A. Phaniband ◽  
Shreedhar D. Dhumwad ◽  
Shashikanth R. Pattan
Keyword(s):  
Metal Complexes ◽  
Schiff Bases ◽  
Dna Cleavage

Synthesis, characterization, DNA cleavage, and in-vitro antimicrobial studies of Co(II), Ni(II), and Cu(II) complexes with Schiff bases of coumarin derivatives

2011 ◽  
Vol 64 (15) ◽  
pp. 2688-2697 ◽  
Author(s):  
Sangamesh A. Patil ◽  
Vinod H. Naik ◽  
Ajaykumar D. Kulkarni ◽  
Shrishila N. Unki ◽  
Prema S. Badami
Keyword(s):  
Schiff Bases ◽  
Dna Cleavage ◽  
Coumarin Derivatives ◽  
Antimicrobial Studies

para metallation of 3-acetyl-chromen-2-one Schiff bases in tetranuclear palladacycles: focus on their biomolecular interaction and in vitro cytotoxicity

2019 ◽  
Vol 48 (33) ◽  
pp. 12496-12511 ◽  
Author(s):  
G. Kalaiarasi ◽  
S. Dharani ◽  
V. M. Lynch ◽  
R. Prabhakaran
Keyword(s):  
Schiff Base ◽  
Schiff Bases ◽  
In Vitro Cytotoxicity ◽  
Biomolecular Interaction ◽  
Schiff Base Ligands

Three tetranuclear (1–3) complexes and a mononuclear (4) palladium(ii) complex were synthesized from 3-acetyl-chromen-2-one Schiff base ligands [H2-3MAC-Rtsc] (where R = H; CH3; C2H5[H2-3MAC-etsc] or C6H5) and potassium tetrachloropalladate.

scholarly journals Cu(II) and Ni(II) Complexes with New Tridentate NNS Thiosemicarbazones: Synthesis, Characterisation, DNA Interaction, and Antibacterial Activity

2019 ◽  
Vol 2019 ◽  
pp. 1-14 ◽  
Author(s):  
Dorian Polo-Cerón
Keyword(s):  
Metal Complexes ◽  
Dna Cleavage ◽  
Thermal Analyses ◽  
Dna Interaction ◽  
Antimicrobial Activities ◽  
Tridentate Ligand ◽  
Bacterial Strains ◽  
Azomethine Group ◽  
Broth Microdilution Method

This paper reports the synthesis and detailed characterisation of copper(II) and nickel(II) complexes with tridentate thiosemicarbazone ligands H2L1 and H2L2 derived from 2-acetylpyrazine. The ligands and their metal complexes were characterised by different physicochemical techniques, including elemental and thermogravimetric analysis; UV-Vis, IR, 1H-NMR, and 13C-NMR spectroscopy; molar conductance measurements; and mass spectrometry. The crystal structure of the H2L1 ligand was determined by single crystal X-ray diffraction studies. The spectral data showed that the thiosemicarbazone behaves as an NNS tridentate ligand through the nitrogen atoms of the azomethine group and pyrazine ring and the sulphur atom of the thioamide group. Elemental and thermal analyses indicated that the obtained metal complexes had a 1 : 1 stoichiometry (metal-ligand). The interactions between these complexes and calf thymus DNA (CT-DNA) were studied by electronic absorption and viscosity measurements. The activities of these compounds against oxidative DNA cleavage were examined by agarose gel electrophoresis. Cu(II) and Ni(II) complexes can wind DNA strands through groove interactions and promote strand breakage of the plasmid pmCherry under oxidative stress conditions. Moreover, all the complexes could interact more strongly with DNA than could with the free ligands. Finally, the antibacterial activities of the ligands and their complexes were determined by in vitro tests against Gram-positive bacterial strains (S. aureus ATCC 25923, L. monocytogenes ATCC 19115, and B. cereus ATCC 10876) and Gram-negative bacterial strains (E. coli ATCC 25922, S. typhimurium ATCC 14028, and K. pneumoniae ATCC BAA-2146) using the broth microdilution method. The metal complexes showed greater antimicrobial activities than the precursor ligands against some of the microorganisms.

New binuclear Ni(ii) metallates containing ONS chelators: synthesis, characterisation, DNA binding, DNA cleavage, protein binding, antioxidant activity, antimicrobial and in vitro cytotoxicity

2017 ◽  
Vol 41 (7) ◽  
pp. 2543-2560 ◽  
Author(s):  
G. Kalaiarasi ◽  
Ruchi Jain ◽  
H. Puschman ◽  
S. Poorna Chandrika ◽  
K. Preethi ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Dna Binding ◽  
Protein Binding ◽  
Hela Cell ◽  
Antiproliferative Activity ◽  
Dna Cleavage ◽  
In Vitro Cytotoxicity ◽  
Hela Cell Lines ◽  
Mcf 7

Four new binuclear nickel(ii) metallates showed promising antiproliferative activity against MCF-7 and HeLa cell lines and were much less toxic against HaCaT.

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