Synthesis, characterization and DNA photocleavage study of a novel dehydroacetic acid based hydrazone Schiff’s base and its metal complexes

2014 ◽  
Vol 23 (7) ◽  
pp. 3327-3335 ◽  
Author(s):  
R. Pal ◽  
V. Kumar ◽  
A. K. Gupta ◽  
V. Beniwal
Keyword(s):  
Metal Complexes ◽  
Schiff’S Base ◽  
Dna Photocleavage ◽  
Dehydroacetic Acid

The formation constants of some metal complexes with 3-Acetyl-4-hydroxycoumarin, dehydroacetic acid, and their oximes

1971 ◽  
Vol 24 (5) ◽  
pp. 925 ◽  
Author(s):  
GCS Manku
Keyword(s):  
Metal Complexes ◽  
Sodium Perchlorate ◽  
Formation Constants ◽  
Ionic Concentration ◽  
Dehydroacetic Acid ◽  
Nitrogen Donors ◽  
Oxygen Donors

The formation constants (K1, K2, and β2) of the complexes of 3-acetyl-4- hydroxycoumarin (ahc) and dehydroacetic acid (dha) and their respective oximes, ahco and dhao, with iron(II), cobalt(II), nickel(II), copper(II), zinc(II), calcium(II), magnesium(II), cadmium(II), dioxouranium(VI), iron(III), aluminium(III), scandium(III), indium(III), yttrium(III), and lanthanon(III) ions (lanthanum to lutetium inclusive with the exception of promethium) have been determined pH-metrically at 35� in 50% v/v aqueous dioxan medium with 0.100M sodium perchlorate as the constant ionic concentration, using Calvin and Wilson's pH-metric technique. The trends in the formation constants of these complexes are discussed. It is observed that, except in the case of Co2+, Ni2+, and Cu2+ ions, for which chelation through nitrogen donors is more favoured, all other ions prefer coordination through oxygen donors.

scholarly journals Synthesis and Structural Studies of Transition Metal Complexes with Bidentate Schiff Base Derived from 3-Acetyl-6-methyl-(2H)-pyran-2,4(3H)-dione

2011 ◽  
Vol 8 (s1) ◽  
pp. S245-S252 ◽  
Author(s):  
Praveen S. Mane ◽  
Sanjiv M. Salunke ◽  
Balagi S. More
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Octahedral Geometry ◽  
Ligand Field ◽  
Schiff Base Ligands ◽  
H Nmr ◽  
Dehydroacetic Acid ◽  
Ligand Field Parameters

The solid complexes of Cu(II), Ni(II), Co(II), Mn(II) and Fe(III) with Schiff base ligands derived from heterocyclic compounds 3-acetyl-6-methyl-(2H)-pyran-2,4(3H)-dione (Dehydroacetic acid) ando-chloroaniline were synthesized and characterized by elemental analysis, conductance, magnetic, thermal, UV-Vis and1H-NMR spectroscopy. The ligand field parameters have been evaluated for Cu(II), Ni(II), Co(II), Mn(II) and Fe(III) complexes which suggest an octahedral geometry for each of them. The magnetic moment and spectral data suggest the dimeric nature of Mn(II) complexes with octahedral geometry. The fungicidal activities of the ligands and their metal complexes have been screened in vitro againstAspergillus nigerand the percentage inhibition of the metal complexes is found to be increased considerably then that of their corresponding ligands and the order is Cu>Ni>Fe>Mn>Co.

Prospects of Biologically Active Schiff's Base Ligand and Metal Complexes in Drug Discovery

2019 ◽  
Vol 11 (1) ◽  
pp. 144-154 ◽  
Author(s):  
Pallavi Jain ◽  
Garima Pandey ◽  
Dinesh Kumar ◽  
Sulekh Chandra
Keyword(s):  
Drug Discovery ◽  
Metal Complexes ◽  
Biologically Active ◽  
Schiff’S Base

Metal complexes of schiff's base derived from salicoylhydrazine and biacetylmonoxime

Polyhedron ◽  
1983 ◽  
Vol 2 (7) ◽  
pp. 583-585 ◽  
Author(s):  
M.M. Mostafa ◽  
M.A. Khattab ◽  
K.M. Ibrahim
Keyword(s):  
Metal Complexes ◽  
Schiff’S Base

scholarly journals Synthesis of Schiff’s Bases from 2-Amino-4H-1, 3-Oxazine / Thiazine and Substituted Aldehydes and their Transition Metal Complexes

2021 ◽  
Vol 04 (07) ◽  
Author(s):  
D.T. Biradar ◽  
Keyword(s):  
Acetic Acid ◽  
Metal Complexes ◽  
Bioactive Molecules ◽  
Schiff’S Bases ◽  
Schiff’S Base ◽  
One Pot ◽  
Solvent Free Condition ◽  
Synthetic Strategy ◽  
Schiff's Bases

Objective: Many methods can be found in literature for the synthesis a Oxazines and Thiazines. Few are reported for one-pot multi component cyclo-condensation of an alkayane urea / Thiourea and Aldehyde to 2- amino-4H-1, 3-Oxazines or Thiazines. Different catalysts are reported like Trifluoro-acetic acid, glacial acetic acid under reflux condition Mandal and Co-workers have utilized perchloric acid (HClO4) supported on silica gel as catalyst under solvent free condition ytterbium trifluorate [Yb(OTF)3] plays role of Lewis acid. It is also used in several Diel’s-Alder cyclo-addition reactions. Inspired these observations, development of simple effective synthetic strategy for the synthesis of 2-amino-4H-1, 3-Oxazium & Thiazines was attempted. Material and Methods: One pot multi-component synthesis of Schiff’s base as new ligand an their complexes with Ni, Fe, Co and Cu and developed using 2-amino-4H-1,3 Oxazines /Thiazines and substituted Aldehydes, different catalyst are used to synthesize of 2-amino 4H-1,3 Oxazines. Its characterization is confirmed by taking IR, NMR spectra. The Schiff’s base act as ligand is bidentate, when it is treated to metal complexes in 1:1 ratio (metal: ligand) complexes are formed. Result: By using the bioactive molecules like 2-amino-4H-1, 3 Oxazine / Thiazines, Schiff’s Bases can be synthesized by using different aldehydes. These Schiff’s Bases has antitumor, antipyretic, anti-inflammatory property. And these Schiff’s bases treated with bioactive metals like Co, Fe, Cu, Zn which enhances their bio-activity. Conclusion: All these synthesized Schiff’ Bases and their metal complexes having bioactive properties.

scholarly journals Spectral, Molecular Modeling, and Biological Activity Studies on New Schiff’s Base of Acenaphthaquinone Transition Metal Complexes

2021 ◽  
Vol 2021 ◽  
pp. 1-17
Author(s):  
Khlood S. Abou Melha ◽  
Gamil A. Al-Hazmi ◽  
Ismail Althagafi ◽  
Arwa Alharbi ◽  
Ali A. Keshk ◽  
...  
Keyword(s):  
Metal Complexes ◽  
Energy Gap ◽  
Free Ligand ◽  
Schiff’S Base ◽  
Strong Activity ◽  
Spectral Techniques ◽  
Dft Modeling ◽  
Base Derivative ◽  
Coordinated Water ◽  
Average Size

The newly synthesized Schiff’s base derivative, N-allyl-2-(2-oxoacenaphthylen-1(2H)-ylidene)hydrazine-1-carbothioamide, has been characterized by different spectral techniques. Its reaction with Co(II), Ni(II), and Zn(II) acetate led to the formation of 1 : 1 (M:L) complexes. The IR and NMR spectral data revealed keto-thione form for the free ligand. On chelation with Co(II) and Ni(II), it behaved as mononegative and neutral tridentate via O, N1, and S donors, respectively, while it showed neutral bidentate mode via O and N1 atoms with Zn(II). The electronic spectra indicated that all the isolated complexes have an octahedral structure. The thermal gravimetric analyses confirmed the suggested formula and the presence of coordinated water molecules. The XRD pattern of the metal complexes showed that both Co(II) and Ni(II) have amorphous nature, while Zn(II) complex has monoclinic crystallinity with an average size of 9.10 nm. DFT modeling of the ligand and complexes supported the proposed structures. The calculated HOMO-LUMO energy gap, ΔEH-L, of the ligand complexes was 1.96–2.49 eV range where HAAT < Zn(II) < Ni(II) < Co(II). The antioxidant activity investigation showed that the ligand and Zn(II) complex have high activity than other complexes, 88.5 and 88.6%, respectively. Accordingly, the antitumor activity of isolated compounds was examined against the hepatocellular carcinoma cell line (HepG2), where both HAAT and Zn(II) complex exhibited very strong activity, IC50 6.45 ± 0.25 and 6.39 ± 0.18 μM, respectively.

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