Experimental and Theoretical Investigations of a Ferrous / Ascorbate Complex

<p>The importance of trace metal ions in biological processes has been known for some time, but the role of chelating molecules in the human body is a comparatively new and interesting field of research Schubert, j., 1966, Scientific American, 214, no. 5, 40. Among the important complexes occuring in the body are haemoglobin, containing iron, and vitamin B-12, containing cobalt, both essential to human health. Other well-known naturally occuring complexes include cytochrome oxidase, containing both iron and copper, and chlorophyll, containing magnesium. The transition metal ions of the First Transition Series are well-known for their ability to form complexes with suitable ligands, and in particular with chelate ligands which can seize the metal ion like a claw (chele means claw in Greek). Many of these complexes have been characterized experimentally, and their properties interpreted by theoretical calculations. However, the complexes arising from biological systems are much more difficult to study, partly because of their greater size and special properties.</p>

Experimental and Theoretical Investigations of a Ferrous / Ascorbate Complex

<p>The importance of trace metal ions in biological processes has been known for some time, but the role of chelating molecules in the human body is a comparatively new and interesting field of research Schubert, j., 1966, Scientific American, 214, no. 5, 40. Among the important complexes occuring in the body are haemoglobin, containing iron, and vitamin B-12, containing cobalt, both essential to human health. Other well-known naturally occuring complexes include cytochrome oxidase, containing both iron and copper, and chlorophyll, containing magnesium. The transition metal ions of the First Transition Series are well-known for their ability to form complexes with suitable ligands, and in particular with chelate ligands which can seize the metal ion like a claw (chele means claw in Greek). Many of these complexes have been characterized experimentally, and their properties interpreted by theoretical calculations. However, the complexes arising from biological systems are much more difficult to study, partly because of their greater size and special properties.</p>

Medicinal Utility of Some Schiff Bases and their Complexes with First Transition Series Metals: A Review

Schiff based ligands and their complexes have emerged as potential drug candidates. Owing to their excellent chelating tendency, they easily coordinate with transition metals which have vacant orbitals. Transition metal complexes have several advantages because of their better acceptability and low toxicity in biological systems. These metals also serve as micronutrients and as co-factors of various metallo-enzymes which justifies the need of their designing and synthesis. Many modifications have been suggested in the ligand moiety for the purpose of activity enhancement and some of them have been described in the present review. These modifications have enhanced better potency against a number of diseases and resulting in low toxicity and better solubility in vivo. The transition metal complexes with Schiff based complexes have exhibited an array of activities including anticancer, antioxidant and antimicrobial. Their analytical applications have also been reported. The present review summarizes some of the recent advances in the field of synthesis and designing of new Schiff based complexes particularly with first transition series metals and their medicinal applications.

Antimicrobial Activities of Schiff Base Metal Complexes of First Transition Series

The correlative antimicrobial analysis of amino acid Schiff base and derivatized tren metal complexes: A= [MLCl2], B= [ML(CH3OH)2], respectively, against fungal strains, Candida parapsilosis, Candida albicans, Candida krusei, and Cryptococcus neoformans and (Gram-negative) P. aeruginosa, E. coli, S. typhimurium, and S. pyogenes, Methicillin-resistant Staphylococcus aureus (MRSA), S. mutans (Gram-positive) bacterial strains had been done by disk diffusion method following McFarland protocol. [CuLCl2] and [Cu (CH3OH)2] manifest overwhelming activity against microbes than other metal complexes of cobalt, nickel and zinc. Minimum inhibition concentration data also shows that copper complexes have the lowest MIC values against these tested microorganisms. The significance of this investigation is to uncover shielding and constructive therapeutic agents that wield against bacterial and fungal infection.

The Carbonate-Hosted Tullacondra Cu-Ag Deposit, Mallow, Ireland

The Tullacondra Cu-Ag deposit is located on the southern margin of the Lower Carboniferous Irish Midlands orefield and contains historical reserves of approximately 4.2 Mt at 0.7% Cu and 27.5 ppm Ag. The deposit is hosted within the hanging wall of a feeder fault, the EW-trending Tullacondra Fault, where sulfides and sulfosalts containing elevated Cu, Ag, As, and Sb deposited, whereas Zn and Pb are nearly absent. The deposition of Cu sulfides in Tullacondra took place along bedding and bedding-parallel dissolution seams, suggesting an epigenetic mineralization that formed: (a) the Transition Series-hosted mineralized zone containing elevated Cu associated with Ag, As, and Sb; (b) the Lower Limestone Shale-hosted mineralized zone, Cu-dominated and depleted in other metals, and (c) a near-vertical mineralized zone associated with fractures related to the Tullacondra Fault. Some similarities are shared with Irish-type Zn-Pb deposits, such as structural and stratigraphic controls, and elevated Cu, Ag, As, and Sb within feeder-fault proximal zones (such as in Lisheen and Silvermines). Whether Tullacondra mineralization was part of the Irish-type system or not, our deposit geometry evaluation, whole-rock geochemistry, paragenetic sequence, and texture relationships indicate that Cu-Ag deposition involved the reaction of metal-bearing fluids with carbonate rocks.

COMPLEXION OF NONIONIC MACROMOLECULES WITH 3RD METAL IONS OF THE TRANSITION SERIES

The article discusses the formation of complexes between transition metal ions and a copolymer of crotonaldehyde with N-vinylpyrrolidone. Complexation of copolymers with metal ions in solutions has been studied by methods of IR-UV spectroscopy, sedimentation, diffusion and viscosimetry. Coordination of the metal with the copolymer occurs through the oxygen atom of the cycloamide and aldehyde groups.

First Transition series metal-organic frameworks: Synthesis, properties and applications

Metal organic frameworks (MOFs) have engrossed massive consideration in the last decade, owing to their better adsorption properties as compared to those of the organic as well as inorganic materials...