Combination of Ionising Irradiation and Hyperthermia Activates Programmed Apoptotic and Necrotic Cell Death Pathways in Human Colorectal Carcinoma Cells

2-Chloroethyl ethyl sulfide (CEES) or half-mustard gas, a sulfur mustard (HD) analog, is a genotoxic agent that causes oxidative stress and induces both apoptotic and necrotic cell death. Sodium pyruvate induced a necrosis-to-apoptosis shift in HaCaT cells exposed to CEES levels ≤ 1.5 mmol/L and lowered markers of DNA damage, oxidative stress, and inflammation. This study provides a rationale for the future development of multicomponent therapies for HD toxicity in the skin. We hypothesize that a combination of pyruvates with scavengers/antioxidants encapsulated in liposomes for optimal local delivery should be therapeutically beneficial against HD-induced skin injury. However, the latter suggestion should be verified in animal models exposed to HD.

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Combination treatment of ergosterol followed by amphotericin B induces necrotic cell death in human hepatocellular carcinoma cells

Oncotarget ◽

10.18632/oncotarget.20285 ◽

2017 ◽

Vol 8 (42) ◽

pp. 72727-72738 ◽

Cited By ~ 2

Author(s):

Yu-Chun Lin ◽

Bao-Hong Lee ◽

Jassey Alagie ◽

Ching-Hua Su

Keyword(s):

Hepatocellular Carcinoma ◽

Cell Death ◽

Amphotericin B ◽

Combination Treatment ◽

Carcinoma Cells ◽

Human Hepatocellular Carcinoma ◽

Necrotic Cell Death ◽

Necrotic Cell ◽

Hepatocellular Carcinoma Cells ◽

Human Hepatocellular Carcinoma Cells

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Iridoids from Valeriana jatamansi induce autophagy-associated cell death via the PDK1/Akt/mTOR pathway in HCT116 human colorectal carcinoma cells

Bioorganic Chemistry ◽

10.1016/j.bioorg.2019.03.020 ◽

2019 ◽

Vol 87 ◽

pp. 136-141 ◽

Cited By ~ 5

Author(s):

Yu-Zhu Tan ◽

Cheng Peng ◽

Chang-Jiang Hu ◽

Hong-Xiang Li ◽

Wen-Bing Li ◽

...

Keyword(s):

Cell Death ◽

Colorectal Carcinoma ◽

Mtor Pathway ◽

Carcinoma Cells ◽

Valeriana Jatamansi ◽

Human Colorectal Carcinoma

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MP83-07 ROLE OF HINT3 IN P21 INDUCED NECROTIC CELL DEATH UPON BCG EXPOSURE IN UROTHELIAL CARCINOMA CELLS

The Journal of Urology ◽

10.1016/j.juro.2016.02.2189 ◽

2016 ◽

Vol 195 (4S) ◽

Author(s):

Gopitkumar Shah ◽

Fanghong Chen ◽

GuangJian Zhang ◽

William See

Keyword(s):

Cell Death ◽

Urothelial Carcinoma ◽

Carcinoma Cells ◽

Necrotic Cell Death ◽

Necrotic Cell

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Cystein cathepsin and Hsp90 activities determine the balance between apoptotic and necrotic cell death pathways in caspase-compromised U937 cells

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research ◽

10.1016/j.bbamcr.2007.07.003 ◽

2007 ◽

Vol 1773 (10) ◽

pp. 1546-1557 ◽

Cited By ~ 3

Author(s):

Gergely Imre ◽

Zsuzsanna Dunai ◽

Istvan Petak ◽

Rudolf Mihalik

Keyword(s):

Cell Death ◽

Necrotic Cell Death ◽

U937 Cells ◽

Necrotic Cell ◽

Cell Death Pathways

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Reactive Oxygen Species, Apoptosis, and Mitochondrial Dysfunction in Hearing Loss

BioMed Research International ◽

10.1155/2015/617207 ◽

2015 ◽

Vol 2015 ◽

pp. 1-7 ◽

Cited By ~ 68

Author(s):

Teru Kamogashira ◽

Chisato Fujimoto ◽

Tatsuya Yamasoba

Keyword(s):

Reactive Oxygen Species ◽

Cell Death ◽

Hearing Loss ◽

Reactive Oxygen ◽

Necrotic Cell Death ◽

Ros Production ◽

Oxygen Species ◽

Necrotic Cell ◽

Cell Death Pathways ◽

Age Related

Reactive oxygen species (ROS) production is involved in several apoptotic and necrotic cell death pathways in auditory tissues. These pathways are the major causes of most types of sensorineural hearing loss, including age-related hearing loss, hereditary hearing loss, ototoxic drug-induced hearing loss, and noise-induced hearing loss. ROS production can be triggered by dysfunctional mitochondrial oxidative phosphorylation and increases or decreases in ROS-related enzymes. Although apoptotic cell death pathways are mostly activated by ROS production, there are other pathways involved in hearing loss that do not depend on ROS production. Further studies of other pathways, such as endoplasmic reticulum stress and necrotic cell death, are required.

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