scholarly journals Intervening before the onset of Type 1 diabetes: baseline data from the European Nicotinamide Diabetes Intervention Trial (ENDIT)

Diabetologia ◽  
2003 ◽  
Vol 46 (9) ◽  
pp. 1296-1296
Keyword(s):  
Type 1 Diabetes ◽  
Baseline Data ◽  
Intervention Trial ◽  
Diabetes Intervention

scholarly journals The Role of Autoantibodies to Zinc Transporter 8 in Prediction of Type 1 Diabetes in Relatives: Lessons from the European Nicotinamide Diabetes Intervention Trial (ENDIT) Cohort

2012 ◽  
Vol 97 (2) ◽  
pp. 632-637 ◽  
Author(s):  
Anna E. Long ◽  
A. Talia Gooneratne ◽  
Saba Rokni ◽  
Alistair J. K. Williams ◽  
Polly J. Bingley
Keyword(s):  
Type 1 Diabetes ◽  
Genetic Risk ◽  
Zinc Transporter ◽  
Intervention Trial ◽  
First Degree Relatives ◽  
Zinc Transporter 8 ◽  
Increased Risk ◽  
Diabetes Intervention

Context: Antibodies to islet autoantigens are detectable many years before clinical onset of type 1 diabetes and can be used to identify individuals at increased risk of diabetes. Zinc transporter 8 is a recently identified islet autoantigen. Objective: Our aim was to determine whether addition of zinc transporter 8 autoantibodies (ZnT8A) improved prediction of type 1 diabetes in a well-characterized cohort of islet cell antibody (ICA)-positive first-degree relatives. We were particularly interested in the role of ZnT8A in prediction in antibody-positive relatives with intermediate and low overall risk of diabetes. Participants and Methods: ZnT8A were assayed in baseline samples from 526 ICA-positive first-degree relatives randomized in the European Nicotinamide Diabetes Intervention Trial. Antibodies to insulin, glutamate decarboxylase, islet antigen-2 (IA-2A) and IA-2β (IA-2βA), and human leukocyte antigen type had been previously determined. Risk of diabetes was assessed by survival analysis. Results: Of 221 ZnT8A-positive individuals, 113 developed diabetes during follow-up (5-yr cumulative risk, 55%). In multivariate models based on other autoantibodies, ZnT8A improved prediction in relatives at low genetic risk of diabetes (P = 0.030) and over age 20 yr (P = 0.026), but not in those with ICA alone or with one additional autoantibody (P = 0.696), IA-2A-negative relatives (P = 0.361), those at high or intermediate genetic risk, or younger relatives. Conclusions: ZnT8A are useful additional risk markers in relatives at low genetic risk of diabetes and older individuals, but they add relatively little in younger populations because of the precise prediction possible with current autoantibody combinations.

scholarly journals Insulin Resistance and Progression to Type 1 Diabetes in the European Nicotinamide Diabetes Intervention Trial (ENDIT)

Diabetes Care ◽  
2007 ◽  
Vol 31 (1) ◽  
pp. 146-150 ◽  
Author(s):  
P. J. Bingley ◽  
J. L Mahon ◽  
E. A.M. Gale ◽  
Keyword(s):  
Insulin Resistance ◽  
Type 1 Diabetes ◽  
Intervention Trial ◽  
Diabetes Intervention

scholarly journals Evaluation of Long-Term Treatment Effect in a Type 1 Diabetes Intervention Trial: Differences After Stimulation With Glucagon or a Mixed Meal

Diabetes Care ◽  
2014 ◽  
Vol 37 (5) ◽  
pp. 1384-1391 ◽  
Author(s):  
Paolo Pozzilli ◽  
Itamar Raz ◽  
Dana Peled ◽  
Dana Elias ◽  
Ann Avron ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Treatment Effect ◽  
Term Treatment ◽  
Intervention Trial ◽  
Mixed Meal ◽  
Long Term Treatment ◽  
Diabetes Intervention

scholarly journals Picky Eaters Improved Diet Quality in a Randomized Behavioral Intervention Trial in Youth with Type 1 Diabetes

2018 ◽  
Vol 118 (2) ◽  
pp. 308-316
Author(s):  
Tonja R. Nansel ◽  
Leah M. Lipsky ◽  
Denise L. Haynie ◽  
Miriam H. Eisenberg ◽  
Katie Dempster ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Behavioral Intervention ◽  
Diet Quality ◽  
Intervention Trial
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