scholarly journals Progression to type 1 diabetes in islet cell antibody-positive relatives in the European Nicotinamide Diabetes Intervention Trial: the role of additional immune, genetic and metabolic markers of risk

Diabetologia ◽  
2006 ◽  
Vol 49 (5) ◽  
pp. 881-890 ◽  
Author(s):  
◽  
P. J. Bingley ◽  
E. A. M. Gale
Keyword(s):  
Type 1 Diabetes ◽  
Islet Cell ◽  
Islet Cell Antibody ◽  
Intervention Trial ◽  
Metabolic Markers ◽  
Cell Antibody ◽  
Diabetes Intervention

Predictive value of islet cell antibody titer at onset of type 1 diabetes for clinical course of the disease

2000 ◽  
Vol 50 ◽  
pp. 347
Author(s):  
A Jotic ◽  
N.M Lalic ◽  
M Zamaklar ◽  
M Bukelica ◽  
K Lalic ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Antibody Titer ◽  
Predictive Value ◽  
Islet Cell ◽  
Clinical Course ◽  
Islet Cell Antibody ◽  
Cell Antibody

scholarly journals The Role of Autoantibodies to Zinc Transporter 8 in Prediction of Type 1 Diabetes in Relatives: Lessons from the European Nicotinamide Diabetes Intervention Trial (ENDIT) Cohort

2012 ◽  
Vol 97 (2) ◽  
pp. 632-637 ◽  
Author(s):  
Anna E. Long ◽  
A. Talia Gooneratne ◽  
Saba Rokni ◽  
Alistair J. K. Williams ◽  
Polly J. Bingley
Keyword(s):  
Type 1 Diabetes ◽  
Genetic Risk ◽  
Zinc Transporter ◽  
Intervention Trial ◽  
First Degree Relatives ◽  
Zinc Transporter 8 ◽  
Increased Risk ◽  
Diabetes Intervention

Context: Antibodies to islet autoantigens are detectable many years before clinical onset of type 1 diabetes and can be used to identify individuals at increased risk of diabetes. Zinc transporter 8 is a recently identified islet autoantigen. Objective: Our aim was to determine whether addition of zinc transporter 8 autoantibodies (ZnT8A) improved prediction of type 1 diabetes in a well-characterized cohort of islet cell antibody (ICA)-positive first-degree relatives. We were particularly interested in the role of ZnT8A in prediction in antibody-positive relatives with intermediate and low overall risk of diabetes. Participants and Methods: ZnT8A were assayed in baseline samples from 526 ICA-positive first-degree relatives randomized in the European Nicotinamide Diabetes Intervention Trial. Antibodies to insulin, glutamate decarboxylase, islet antigen-2 (IA-2A) and IA-2β (IA-2βA), and human leukocyte antigen type had been previously determined. Risk of diabetes was assessed by survival analysis. Results: Of 221 ZnT8A-positive individuals, 113 developed diabetes during follow-up (5-yr cumulative risk, 55%). In multivariate models based on other autoantibodies, ZnT8A improved prediction in relatives at low genetic risk of diabetes (P = 0.030) and over age 20 yr (P = 0.026), but not in those with ICA alone or with one additional autoantibody (P = 0.696), IA-2A-negative relatives (P = 0.361), those at high or intermediate genetic risk, or younger relatives. Conclusions: ZnT8A are useful additional risk markers in relatives at low genetic risk of diabetes and older individuals, but they add relatively little in younger populations because of the precise prediction possible with current autoantibody combinations.

The Combination of Antibodies to GAD-65 and IA-2ic Can Replace the Islet-Cell Antibody Assay to Identify Subjects at Risk of Type 1 Diabetes Mellitus

1999 ◽  
Vol 31 (10) ◽  
pp. 564-569 ◽  
Author(s):  
E. Hatziagelaki ◽  
C. Jaeger ◽  
R. Petzoldt ◽  
J. Seissler ◽  
W. Scherbaum ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
At Risk ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Islet Cell ◽  
Islet Cell Antibody ◽  
Antibody Assay ◽  
Cell Antibody ◽  
Gad 65

scholarly journals Factors associated with increased irisin levels in the type 1 diabetes mellitus

2017 ◽  
Vol 51 (1) ◽  
pp. 1-7 ◽  
Author(s):  
I. Ates ◽  
M. F. Arikan ◽  
K. Erdogan ◽  
M. Kaplan ◽  
M. Yuksel ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Glycosylated Hemoglobin ◽  
Islet Cell Antibody ◽  
Acid Decarboxylase ◽  
Insulin Autoantibody ◽  
Cell Antibody ◽  
Positive Groups

Abstract Objective. The aim of the present study was to determine the irisin levels in patients with the type 1 diabetes mellitus (T1DM) and to examine the relation of irisin levels with the inflammation and autoimmunity.Methods. This study included 35 cases diagnosed with T1DM and 36 healthy volunteers. Antiglutamic acid decarboxylase (anti-GAD), islet cell antibody (ICA), and insulin autoantibody levels were measured in patients at the time when they were included into the study and recorded from the patient files. Serum irisin levels were measured by ELISA kit.Results. The median irisin levels were determined higher in T1DM group compared to the control one (6.8 ng/ml vs. 4.8 ng/ml, p=0.022; respectively). Median irisin levels were higher in anti-GAD (p=0.022) and ICA (p=0.044) positive groups compared to negative groups. In T1DM group, irisin levels displayed positive correlation with glycosylated hemoglobin (HbA1c) (r=0.377, p<0.001) and anti-GAD (r=0.392, p=0.020) and negative correlation with creatinine (r=-0390, p=0.021). In multivariate regression model, HbA1c (B±SE: 2.76±17683, p<0.001), and anti-GAD (B±SE: 2.311±0.610, p=0.001) were determined as independent predictors for predicting the irisin levels.Conclusion. In patients with T1DM, which chronic inflammation and autoimmunity take part in their etiopathogenesis, anti-GAD levels were an independent risk factor for the irisin. Th is may suggest that factors such as inflammation and autoimmunity can be effective in the synthesis of irisin.

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