scholarly journals The p21-activated kinase (PAK1) is involved in diet-induced beta cell mass expansion and survival in mice and human islets

Diabetologia ◽  
2016 ◽  
Vol 59 (10) ◽  
pp. 2145-2155 ◽  
Author(s):  
Miwon Ahn ◽  
Stephanie M. Yoder ◽  
Zhanxiang Wang ◽  
Eunjin Oh ◽  
Latha Ramalingam ◽  
...  
Keyword(s):  
Beta Cell ◽  
Cell Mass ◽  
Beta Cell Mass ◽  
Human Islets ◽  
P21 Activated Kinase ◽  
Mass Expansion

scholarly journals Prolactin-stimulated survivin induction is required for beta cell mass expansion during pregnancy in mice

Diabetologia ◽  
2015 ◽  
Vol 58 (9) ◽  
pp. 2064-2073 ◽  
Author(s):  
Yili Xu ◽  
Xiaojing Wang ◽  
Li Gao ◽  
Jiayu Zhu ◽  
Hui Zhang ◽  
...  
Keyword(s):  
Beta Cell ◽  
Cell Mass ◽  
Beta Cell Mass ◽  
Mass Expansion

A SELECTIVE DECREASE IN THE BETA CELL MASS OF HUMAN ISLETS TRANSPLANTED INTO DIABETIC NUDE MICE

1995 ◽  
Vol 59 (6) ◽  
pp. 817-820 ◽  
Author(s):  
A. M. DAVALLI ◽  
Y. OGAWA ◽  
C. RICORDI ◽  
D. W. SCHARP ◽  
S. BONNER-WEIR ◽  
...  
Keyword(s):  
Beta Cell ◽  
Nude Mice ◽  
Cell Mass ◽  
Beta Cell Mass ◽  
Human Islets

scholarly journals miRNA-375 a Sensor of Glucotoxicity Is Altered in the Serum of Children with Newly Diagnosed Type 1 Diabetes

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Lucien Marchand ◽  
Audrey Jalabert ◽  
Emmanuelle Meugnier ◽  
Kathleen Van den Hende ◽  
Nicole Fabien ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Beta Cell ◽  
Cell Mass ◽  
Beta Cell Mass ◽  
Human Islets ◽  
Rt Pcr ◽  
Stem Loop ◽  
Cell Alterations ◽  
Established Role

Background.The use of miRNAs as biomarkers for Type 1 Diabetes (T1D) risk is attractive as T1D is usually diagnosed in front of acute symptoms. As miR-375 is highly expressed in the endocrine pancreas, we postulated that its circulating level might reflect beta cell alterations and might be altered in the blood of T1D patients recently diagnosed.Methods.Sera were obtained from 22 T1D children at onset of the disease, before subcutaneous insulin treatment, and from 10 nondiabetic pediatric controls. MiR-375 seric level was quantified by stem-loop RT-PCR-based assay. MiRNAs regulations in isolated human islets in response to high glucose concentrations were determined by TaqMan Low-Density Array.Results.The abundance of miR-375, among the 410 miRNAs detected in human islets, mirrored its well-established role in rodent islet biology. Upregulated miRNAs targeted genes involved in islet homeostasis and regulation of beta cell mass. Downregulated miRNAs, including miR-375, were involved in pancreas secretion and protein turnover. Seric level of miR-375 was lower in T1D children versus age-matched controls, without any correlations with HbA1c, glycaemia, and number of autoantibodies.Conclusion.Altered circulating level of miR-375 at onset of T1D might be a general biomarker of metabolic alterations and inflammation associated with the disease.

scholarly journals Evidence for the homeostatic regulation of induced beta cell mass expansion

Diabetologia ◽  
2006 ◽  
Vol 49 (12) ◽  
pp. 2910-2919 ◽  
Author(s):  
M. A. Lipsett ◽  
E. B. Austin ◽  
M. L. Castellarin ◽  
J. Lemay ◽  
L. Rosenberg
Keyword(s):  
Beta Cell ◽  
Cell Mass ◽  
Beta Cell Mass ◽  
Homeostatic Regulation ◽  
Mass Expansion

scholarly journals Non-invasive monitoring of glycemia-induced regulation of GLP-1R expression in murine and human islets of langerhans

2020 ◽  
Author(s):  
Ada Admin ◽  
Mijke Buitinga ◽  
Christian M.Cohrs ◽  
Wael A.Eter ◽  
Lieke Claessens-Joosten ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Beta Cell ◽  
Cell Mass ◽  
Beta Cell Mass ◽  
Human Islets ◽  
Tracer Uptake ◽  
Expression Levels ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Islet Volume

GLP-1R imaging with radiolabelled exendin has proven to be a powerful tool to quantify beta-cell mass (BCM) <i>in vivo</i>. As GLP-1R expression is thought to be influenced by glycemic control, we examined the effect of blood glucose levels on GLP-1R-mediated exendin uptake in both murine and human islets and its implications for BCM quantification. Periods of hyperglycemia significantly reduced exendin uptake in murine and human islets, which was paralleled by a reduction in GLP-1R expression. Detailed mapping of the tracer uptake and insulin and GLP-1R expression conclusively demonstrated that the observed reduction in tracer uptake directly correlates to GLP-1R expression levels. Importantly, the linear correlation between tracer uptake and beta-cell area was maintained in spite of the reduced GLP-1R expression levels. Subsequent normalization of blood glucose levels restored absolute tracer uptake and GLP-1R expression in beta-cells and the observed loss in islet volume was halted. <p>This manuscript emphasizes the potency of nuclear imaging techniques to monitor receptor regulation non-invasively. Our findings have significant implications for clinical practice, indicating that blood glucose levels should be near-normalized for at least three weeks prior to GLP-1R agonist treatment or quantitative radiolabeled exendin imaging for BCM analysis.</p>

A SELECTIVE DECREASE IN THE BETA CELL MASS OF HUMAN ISLETS TRANSPLANTED INTO DIABETIC NUDE MICE

1995 ◽  
Vol 59 (6) ◽  
pp. 817-820 ◽  
Author(s):  
A. M. DAVALLI ◽  
Y. OGAWA ◽  
C. RICORDI ◽  
D. W. SCHARP ◽  
S. BONNER-WEIR ◽  
...  
Keyword(s):  
Beta Cell ◽  
Nude Mice ◽  
Cell Mass ◽  
Beta Cell Mass ◽  
Human Islets

scholarly journals Survivin Is Required for Beta-Cell Mass Expansion in the Pancreatic Duct-Ligated Mouse Model

PLoS ONE ◽  
2012 ◽  
Vol 7 (8) ◽  
pp. e41976 ◽  
Author(s):  
Xiaohong Wu ◽  
Qinfeng Zhang ◽  
Xiaojing Wang ◽  
Jiayu Zhu ◽  
Kuangfeng Xu ◽  
...  
Keyword(s):  
Mouse Model ◽  
Beta Cell ◽  
Pancreatic Duct ◽  
Cell Mass ◽  
Beta Cell Mass ◽  
Mass Expansion

scholarly journals TREATMENT WITH EXENATIDE PRESERVES BETA CELL MASS IN HUMAN ISLETS DURING CULTURE: IMPLICATIONS FOR ISLET TRANSPLANTATION

2010 ◽  
Vol 90 ◽  
pp. 1001
Author(s):  
L. Marzban ◽  
Z. Ao ◽  
T. J. Kieffer ◽  
M. Meloche ◽  
N. Safikhan ◽  
...  
Keyword(s):  
Beta Cell ◽  
Islet Transplantation ◽  
Cell Mass ◽  
Beta Cell Mass ◽  
Human Islets
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