Comparison of the effects of gemfibrozil (600 mg twice daily and 900 mg once daily) on lipid and glucose levels in chinese patients with non—insulin-dependent diabetes mellitus

1995 ◽  
Vol 56 (10) ◽  
pp. 1033-1040 ◽  
Author(s):  
Gary T.C. Ko ◽  
Vincent T.F. Yeung ◽  
Lynn W.W. Tsang ◽  
Chun-Chung Chow ◽  
Clive S. Cockram
1997 ◽  
Vol 31 (6) ◽  
pp. 671-676 ◽  
Author(s):  
Gabriele E Sonnenberg ◽  
Dyal C Garg ◽  
Donald J Weidler ◽  
Russell M Dixon ◽  
Linda A Jaber ◽  
...  

OBJECTIVE: To investigate the metabolic effects and frequency of adverse events with 6 mg of glimepiride, a new oral sulfonylurea, given both in once- and twice-daily dosages to patients with non-insulin-dependent diabetes mellitus (NIDDM). RESEARCH DESIGN AND METHODS: This 15-week study involved 161 subjects with NIDDM. Subjects were randomized into two groups. For 4 weeks, group 1 received glimepiride 3 mg twice daily, and group 2 received glimepiride 6 mg once daily. After a 3-week placebo-washout period, twice- and once-daily regimens were crossed over for a second 4-week treatment period. Subjects were hospitalized at the end of each placebo or active-treatment phase. Their glucose concentrations were recorded at 20 time points over a 24-hour period, and their insulin and C-peptide concentrations were recorded at 16 time points over the same period. Parameters that were calculated included fasting, 24-hour, and postprandial concentrations of glucose, insulin, and C-peptide. RESULTS: One hundred six patients were randomized to receive treatment; 94 completed the entire study. Existing physiologic mechanisms of glucose control were apparently unimpaired by glimepiride treatment. Insulin concentrations increased more during the postprandial glucose peaks than when subjects were fasting. Both twice- and once-daily regimens proved equally effective in reducing concentrations of fasting, postbreakfast, postlunch, and postdinner plasma glucose. Twenty-four-hour mean glucose concentrations showed a slightly greater decrease from baseline for the twice-daily regimen; the difference between the regimens was statistically significant but not clinically meaningful. The incidence of adverse events with glimepiride approximated that obtained with placebo, with both groups reporting only one adverse event, headache, in more than 5% of the subjects. CONCLUSIONS: Glimepiride is equally effective whether administered once or twice daily. Glimepiride seems to stimulate insulin production primarily after meals, when plasma glucose concentrations are highest, but controls blood glucose throughout the day.


1987 ◽  
Vol 9 (5) ◽  
pp. 155-162
Author(s):  
John W. Reynolds

1. All foods should be labeled to indicate the calories, sources of the calories, the mineral and vitamin content, the types and amounts of carbohydrates, the amount of cholesterol and amounts and types of fatty acids, and the amount and type of artificial sweetener, if any. 2. A long-term evaluation of the exchange system in the dietary instruction of patients with insulin-depedent diabetes mellitus and their families should be carried out. 3. General guidelines for meal plans for youngsters with diabetes should allow for flexibility and variety in food selection so that they account for individual differences as well as being applicable to different socio-economic, cultural, and ethnic groups. 4. The distribution of calories in the diet should be: 50% to 60% carbohydrate, 15% to 20% protein, and 20% to 25% fat. 5. Nutrition education of the patient with insulin-dependent diabetes mellitus and of the patient's family about the principles of good nutrition, the importance of a balanced meal plan, and the rationale for food prohibitions should be a critical part of diabetes care. 6. Nutritional assessment should include plotting height and weight measurements on standard growth grids at regular intervals. 7. Scientifically sound cross-over studies of the differences between "simple" and "complex" carbohydrates need to be carried out on children with insulin-dependent diabetes mellitus. 8. Before optimal and safe use of fiber in therapy of children is possible, further studies are needed of the convenience and palatability of meals with currently available fiber, the use of "medicated foods" to which specific types of fiber have been added, and the extent of trace element and mineral binding by various fibers. 9. More studies are needed concerning the effects of food form, nutrient-nutrient interactions, and non-nutritive constituents of food on the glycemic effect of a given food. 10. Fructose and sorbitol may be used in limited amounts as parts of an otherwise nutritious and well-balanced meal plan, but the usefulness of their chronic ingestion has not been established. 11. Fructose and sorbitol are not substitutes for artificial noncaloric sweeteners and should not be used in the belief that they are of use in weight control. 12. Aspartame contains no calories and has no apparent risks. However, consumption of large amounts of granulated aspartame, which contains a lactose or dextrose carrier, could affect blood glucose levels. The use of cyclamate and saccharin by children with insulin-dependent diabetes mellitus should be limited pending further review. 13. The use of combinations of artificial sweeteners is reasonable to limit the risks associated with any one sweetener. 14. The medical profession and patients with insulin-dependent diabetes mellitus should be made aware that the disease is a disorder of lipid metabolism as well as carbohydrate metabolism. 15. Cholesterol and saturated fat intake should be limited and the total calories from fat should be reduced to 20% to 25% of the caloric intake. 16. Patients with insulin-dependent diabetes mellitus should have at least yearly monitoring of their fasting serum total and high-density lipoprotein cholesterol levels and the triglyceride levels. 17. The patient with insulin-dependent diabetes mellitus should be taught that, in addition to control of the dietary lipid intake, limitation of the high rate of cardiovascular complications associated with insulin-dependent diabetes mellitus depends on excellent control of blood glucose levels, age-appropriate aerobic exercise, and avoidance of the use of tobacco in any form. 18. Blood pressure should be monitored every 6 to 12 months. It is critical that hypertension be diagnosed and treated early. 19. Young patients with insulin-dependent diabetes mellitus, and their families, should be educated in a prudent approach to the use of dietary salt, with little use of added salt and a choice of foods without excessive sodium content. However, supplemental sodium chloride may be warranted when there is glycosuria in a newly diagnosed or poorly controlled patient. 20. Insulin-dependent diabetes mellitus does not result in increased dietary requirements for iron, magnesium, zinc, selenium, chromium, or other trace minerals or vitamins and, therefore, should not be an indication per se for mineral or vitamin supplements. 21. Nutritionists and dietitians with expertise in the treatment of childhood and adolescent diabetes should be recognized as valuable members of a multidisciplinary diabetes health care team. The role of such a nutritionist or dietitian includes an initial assessment and then later adjustment of meal plans to be consistent with the patient's growth, development, changes in activity level, and appearance of complications. 22. Families should be advised to follow principles of good nutrition in their own meal planning as a way to increase dietary compliance by their children with insulin-dependent diabetes mellitus. Flexibility in meal plans should be encouraged as a way to maximize dietary compliance.


2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
R. S. Sánchez Peña ◽  
A. S. Ghersin ◽  
F. D. Bianchi

This work considers the problem of automatically controlling the glucose level in insulin dependent diabetes mellitus (IDDM) patients. The objective is to include several important and practical issues in the design: model uncertainty, time variations, nonlinearities, measurement noise, actuator delay and saturation, and real time implementation. These are fundamental issues to be solved in a device implementing this control. Two time-varying control procedures have been proposed which take into consideration all of them: linear parameter varying (LPV) and unfalsified control (UC). The controllers are implemented with low-order dynamics that adapt continuously according to the glucose levels measured in real time in one case (LPV) and by controller switching based on the actual performance in the other case (UC). Both controllers have performed adequately under all these practical restrictions, and a discussion on pros and cons of each method is presented at the end.


Author(s):  
Anup K Rana ◽  
Subhashree Ray

Background: Diabetes is a group of disorders characterized by high blood glucose levels. Disturbances in serum electrolytes sodium (Na+), potassium (K+) and chloride (Cl‑) is found in diabetes. The objective of the study was to investigate the disturbances in concentrations of serum electrolytes in hyperglycaemic crisis, uncontrolled non – insulin dependent diabetes mellitus patients: early detection and treatment of such abnormalities, leading to better quality of life of patients.Methods: Data was collected prospectively over a period of 1 year and analyzed retrospectively. Of the 131 subjects included in the study, two groups were formed; 60 hyperglycaemic diabetes mellitus patients and 71 healthy volunteer as controls. Biochemical analysis for Na+, K+, Cl- was performed by ISE method using Easy – lyte automatic electrolyte analyzer. The random glucose levels were estimated by direct Hexokinase enzymatic method using Cobas Interga 400. Unpaired t-test was done to find out the difference between the two paired groups and Pearson's correlation was calculated to know the correlations between electrolytes and random glucose levels.Results: In uncontrolled diabetes mellitus, increase in serum Na+ and Cl- levels were observed to be highly significant (p<0.001, respectively) while that of K+ showed significant (p<0.05) alterationsConclusions: The study demonstrated significant association of Na+, K+ and Cl- with hyperglycaemia in patients with hyperglycaemic crisis in uncontrolled type 2 diabetes mellitus. So, electrolytes should be measured during the treatment of type 2 diabetes mellitus.


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