scholarly journals Source-specific host response and outcomes in critically ill patients with sepsis: a prospective cohort study

Author(s):  
Hessel Peters-Sengers ◽  
Joe M. Butler ◽  
Fabrice Uhel ◽  
Marcus J. Schultz ◽  
Marc J. Bonten ◽  
...  
PLoS ONE ◽  
2019 ◽  
Vol 14 (9) ◽  
pp. e0222095 ◽  
Author(s):  
Claudmeire Dias Carneiro de Almeida ◽  
Ana Cristina Simões e Silva ◽  
João Antonio de Queiroz Oliveira ◽  
Isabela Soares Fonseca Batista ◽  
Fernando Henrique Pereira ◽  
...  

Author(s):  
Charles Chin Han Lew ◽  
Gabriel Jun Yung Wong ◽  
Ka Po Cheung ◽  
Ai Ping Chua ◽  
Mary Foong Fong Chong ◽  
...  

There is limited evidence for the association between malnutrition and hospital mortality as well as Intensive Care Unit length-of-stay (ICU-LOS) in critically ill patients. We aimed to examine the aforementioned associations by conducting a prospective cohort study in an ICU of a Singapore tertiary hospital. Between August 2015 and October 2016, all adult patients with ≥24 h of ICU-LOS were included. The 7-point Subjective Global Assessment (7-point SGA) was used to determine patients’ nutritional status within 48 hours of ICU admission. Multivariate analyses were conducted in two ways: 1) presence versus absence of malnutrition, and 2) dose-dependent association for each 1-point decrease in the 7-point SGA. There were 439 patients of which 28.0% were malnourished, and 29.6% died before hospital discharge. Malnutrition was associated with an increased risk of hospital mortality [adjusted-RR 1.39 (95%CI: 1.10–1.76)], and this risk increased with a greater degree of malnutrition [adjusted-RR 1.09 (95%CI: 1.01–1.18) for each 1-point decrease in the 7-point SGA]. No significant association was found between malnutrition and ICU-LOS. Conclusion: There was a clear association between malnutrition and higher hospital mortality in critically ill patients. The association between malnutrition and ICU-LOS could not be replicated and hence requires further evaluation.


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