Incremental sheet forming is a cost-effective process for rapid manufacturing of sheet metal products. However, incremental sheet forming also has some limitations such as severe sheet thinning and long processing time. These limitations hamper the forming part quality and production efficiency, thus restricting the incremental sheet forming application in industrial practice. To overcome the problem of sheet thinning, a variety of processes, such as multi-step incremental sheet forming, have been proposed to improve the material flow and thickness distribution. In this work, a new process has been developed by introducing multi-point forming as preforming step before conducting incremental sheet forming processing. Employing an established hybrid sheet forming system and the corresponding thickness prediction model, the preform shape can be optimized by employing a two-step optimization approach to improve the sheet thickness distribution. In total, two case study examples, including a hemisphere part and an aerospace cowling part, are fabricated using the developed hybrid flexible process in this study. The experimental results show that the hybrid flexible forming process with the optimal preform design could achieve sheet parts with more uniform thickness distribution and reduced forming time.