scholarly journals Changes in connective tissue in patients with pelvic organ prolapse—a review of the current literature

2008 ◽  
Vol 20 (4) ◽  
pp. 461-474 ◽  
Author(s):  
M. H. Kerkhof ◽  
L. Hendriks ◽  
H. A. M. Brölmann
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
A. Esber ◽  
A. Kopera ◽  
M. P. Radosa ◽  
I. B. Runnebaum ◽  
H. K. Mothes ◽  
...  

Abstract Background Conditions such as genital prolapse and hernia are known to be related to connective tissue dysfunction. In this report on cases of the rare simultaneous finding of large genital prolapse and post-prolapse repair female inguinal bladder hernia, we aim to contribute to the discussion of a possible clinical definition of connective tissue weakness, for its clinical assessment and preoperative patient counselling. Case presentation Three cases of medial third-grade (MIII, Aachen classification) inguinal bladder hernia developing or enlarging after successful stage-IV pelvic organ prolapse (POP) repair at a university pelvic floor centre are presented. All patients were aged ≥ 80 years with long-standing postmenopausal status. One patient was followed for 5 years and two patients were followed for 6 months. In all patients, ultrasound revealed that the hernia sac contained the urinary bladder, which had herniated through the inguinal hernia orifice. A literature search revealed only one case report of direct female inguinal bladder hernia and few investigations of the simultaneous occurrence of POP and hernia in general. Conclusion The simultaneous occurrence of inguinal hernia and female POP can lead to bladder herniation following prolapse surgery in the sense of a “locus minoris resistentiae”. Clinical examination for simultaneous signs of connective tissue weakness and counselling prior to pelvic reconstructive surgery could help to increase patients’ compliance with further surgical treatment for hernia.


2018 ◽  
Vol 13 (4) ◽  
pp. 1800086
Author(s):  
Xiang‐Juan Li ◽  
Hai‐Tao Pan ◽  
Juan‐Juan Chen ◽  
Yi‐Bin Fu ◽  
Min Fang ◽  
...  

2007 ◽  
Vol 86 (7) ◽  
pp. 882-888 ◽  
Author(s):  
Rafi Suzme ◽  
Onay Yalcin ◽  
Figen Gurdol ◽  
Funda Gungor ◽  
Ayhan Bilir

2021 ◽  
Vol 31 (6) ◽  
pp. 531-536
Author(s):  
Dmitry Y. Pushkar ◽  
George R. Kasyan ◽  
Alexander A. Popov

2015 ◽  
Vol 21 (2) ◽  
pp. 324-333 ◽  
Author(s):  
Svetlana L. Kotova ◽  
Peter S. Timashev ◽  
Anna E. Guller ◽  
Anatoly B. Shekhter ◽  
Pavel I. Misurkin ◽  
...  

AbstractWe used atomic force microscopy (AFM) to diagnose pathological changes in the extracellular matrix (ECM) of skin connective tissue in patients with pelvic organ prolapse (POP). POP is a common condition affecting women that considerably decreases the patients’ quality of life. Deviations from normal morphology of the skin ECM from patients with POP occur including packing and arrangement of individual collagen fibers and arrangement of collagen fibrils. The nanoindentation study revealed significant deterioration of the mechanical properties of collagen fibril bundles in the skin of POP patients as compared with the skin of healthy subjects. Changes in the skin ECM appeared to correlate well with changes in the ECM of the pelvic ligament tissue associated with POP. AFM data on the ECM structure of normal and pathologically altered connective tissue were in agreement with results of the standard histological study on the same clinical specimens. Thus, AFM and related techniques may serve as independent or complementary diagnostic tools for tracking POP-related pathological changes of connective tissue.


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