scholarly journals EFFICACY OF PERSONALIZED THERAPY FOR PELVIC ORGAN PROLAPSE DEPENDING ON THE PRESENCE OF UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA

2021 ◽  
pp. 77-83
Author(s):  
N. A. Lysov ◽  
G. I. Teleeva ◽  
L. S. Tselkovich ◽  
T. V. Ivanova ◽  
O. V. Tyumina ◽  
...  
Keyword(s):  
Pelvic Organ Prolapse ◽  
Connective Tissue ◽  
Pelvic Organ ◽  
Personalized Therapy ◽  
Connective Tissue Dysplasia

scholarly journals Signs of connective tissue dysplasia in women with genital prolapse

2021 ◽  
Vol 15 (1) ◽  
pp. 32-40
Author(s):  
A. S. Ustyuzhina ◽  
M. A. Solodilova ◽  
A. V. Polonikov ◽  
S. P. Pakhomov ◽  
U. G. Shokirova
Keyword(s):  
Pelvic Organ Prolapse ◽  
Connective Tissue ◽  
Varicose Veins ◽  
Genital Prolapse ◽  
Pelvic Organ ◽  
Main Group ◽  
Control Group ◽  
Systematic Analysis ◽  
Healthy Women ◽  
Connective Tissue Dysplasia

Introduction. Despite a long history of the disease, genital prolapse still have not been definitively solved. A relevance of pelvic organ prolapse in women has been increasing in recent years largely due to a change in the quality of life and desire to sustain their youth. The number of studies pinpointing the cause of the disease in connective tissue dysplasia (CTD) has been increasing annually.Aim: to conduct a systematic analysis and determine most common signs of CTD in women with genital prolapse.Materials and methods. CTD criteria and the relationship with genital prolapse were analyzed. The study was conducted using questionnaires and including clinical studies examining residents of the Belgorod region (135 women). The main group included 91 patients who had signs of pelvic organ prolapse, and control group consisted of 44 healthy women. CTD intensity score proposed by T.Yu. Smolnova et al. (2003) was used to assess signs of dysplasia in women examined allowing to build up three groups in which each symptom was evaluated as severity score.Results. Asthenic constitution was noted in high percentage of women suffering from genital prolapse (16.70 ± 0.38 %) compared with healthy women (2.30 ± 0.15 %; p = 0.016). Mild bruising, increased tissue bleeding tended to rise in main vs. control group (16.50 ± 0.37 % in main group and 0.0 in control group; p = 0.016). Signs of varicose veins and hemorrhoids requiring no surgical treatment were found in 33.00 ± 0.47 % and 4.50 ± 0.21 % in main vs. control group (p = 0.0002), respectively. Genital prolapse and hernia in first-line relatives were recorded in 9.90 ± 0.30 % in main group (p = 0.031), women without signs of prolapse did not indicate prolapse in close relatives.Conclusion. Asthenic constitution, hernias, varicose veins and hemorrhoids, female pelvic and hernial prolapse in close female relatives, a tendency to mild bruising, skeletal anomalies, elastosis skin were among common CTD signs in women with genital prolapse.

Support role undifferentiated connective tissue dysplasia in genital organ rolapse evolution

2021 ◽  
Author(s):  
М.С. Селихова ◽  
В.В. Скворцов ◽  
Г.В. Ершов ◽  
А.Г. Ершов ◽  
Г.И. Малякин
Keyword(s):  
Risk Factors ◽  
Pelvic Organ Prolapse ◽  
Connective Tissue ◽  
Pelvic Floor ◽  
Connective Tissue Diseases ◽  
Significant Risk ◽  
Genital Prolapse ◽  
Pelvic Organ ◽  
Genital Organ ◽  
Connective Tissue Dysplasia

Одним из наиболее значимых факторов риска формирования опущений и выпадений внутренних половых органов являются заболевания соединительной ткани. Неуклонный рост числа женщин, страдающих пролапсом органов малого таза, привел к тому, что данная патология стала как медицинской, так и социально-экономической проблемой во многих странах. В то же время данные о роли недифференцированных дисплазий соединительной ткани в развитии пролапса органов малого таза и в формировании недостаточности тазового дна и возможности использования ее с целью прогнозирования данной патологии разноречивы. С целью определения взаимосвязи проявления недифференцированных дисплазий соединительной ткани с развитием пролапса органов малого таза был проведен ретроспективный анализ 157 историй болезни пациенток с пролапсом гениталий. У 27,39% пациенток были отмечены проявления дисплазий соединительной ткани. В 39,53% случаев было выявлено сочетание проявления недифференцированных дисплазий соединительной ткани с родовым травматизмом. У 16,28% от количества случаев с родовым травматизмом и пролапсом органов малого таза выявлены выраженные формы дисплазии соединительной ткани (варикозное расширение вен нижних конечностей, полипоз кишечника, пролапс митрального клапана), потребовавшие хирургической коррекция до беременности или после родов. Выявленная у каждой третьей пациентки, оперированной по поводу несостоятельности тазового дна, недифференцированная дисплазия соединительной ткани позволяет рассматривать ее как фактор риска развития пролапса органов малого таза, особенно в сочетании с травматизацией промежности в родах. Однако для оценки роли и значимости патологии соединительной ткани в прогнозировании формирования опущения и выпадения внутренних половых органов малого таза у женщин необходимы проспективные рандомизированные исследования. One of the most significant risk factors for the formation of internal genital organs is connective tissue diseases. The steady increase in the number of women suffering from pelvic organ prolapse has led to the fact that this pathology has become both a medical and socio-economic problem in many countries. At the same time, the data on the role of undifferentiated connective tissue dysplasias in the development of pelvic organ prolapse and in the formation of pelvic floor insufficiency and the possibility of using it to predict this pathology are contradictory. To determine the relationship between the manifestation of undifferentiated connective tissue dysplasia and the development of pelvic organ prolapse, a retrospective analysis of 157 case histories of patients with genital prolapse was carried out. In 27,39% of patients, manifestations of connective tissue dysplasia were noted. In 39,53% of cases, a combination of the manifestation of undifferentiated connective tissue dysplasias with birth traumatism was revealed. Severe forms of connective tissue dysplasia (varicose veins of the lower extremities, intestinal polyposis, mitral valve prolapse) were found in 16,28% of the number of cases with birth traumatism and pelvic organ prolapse, which required surgical correction before pregnancy or after childbirth. Revealed in every third patient operated on for pelvic floor incompetence, undifferentiated connective tissue dysplasias allows us to consider it as a risk factor for pelvic organ prolapse, especially in combination with perineal trauma during childbirth. However, to assess the role and significance of connective tissue pathology in predicting the formation of prolapse and prolapse of the internal genital organs of the small pelvis in a woman, prospective randomized studies are needed. Keywords: genital prolapse, connective tissue dysplasia, risk factors, social-active age, surgical treatment.

scholarly journals “Locus minoris resistentiae” and connective tissue weakness in older women: a case report and literature review on pelvic organ prolapse with inguinal bladder hernia

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
A. Esber ◽  
A. Kopera ◽  
M. P. Radosa ◽  
I. B. Runnebaum ◽  
H. K. Mothes ◽  
...  
Keyword(s):  
Case Report ◽  
Inguinal Hernia ◽  
Pelvic Organ Prolapse ◽  
Connective Tissue ◽  
Genital Prolapse ◽  
Pelvic Organ ◽  
Simultaneous Occurrence ◽  
Patient Counselling ◽  
Hernia Sac ◽  
Bladder Hernia

Abstract Background Conditions such as genital prolapse and hernia are known to be related to connective tissue dysfunction. In this report on cases of the rare simultaneous finding of large genital prolapse and post-prolapse repair female inguinal bladder hernia, we aim to contribute to the discussion of a possible clinical definition of connective tissue weakness, for its clinical assessment and preoperative patient counselling. Case presentation Three cases of medial third-grade (MIII, Aachen classification) inguinal bladder hernia developing or enlarging after successful stage-IV pelvic organ prolapse (POP) repair at a university pelvic floor centre are presented. All patients were aged ≥ 80 years with long-standing postmenopausal status. One patient was followed for 5 years and two patients were followed for 6 months. In all patients, ultrasound revealed that the hernia sac contained the urinary bladder, which had herniated through the inguinal hernia orifice. A literature search revealed only one case report of direct female inguinal bladder hernia and few investigations of the simultaneous occurrence of POP and hernia in general. Conclusion The simultaneous occurrence of inguinal hernia and female POP can lead to bladder herniation following prolapse surgery in the sense of a “locus minoris resistentiae”. Clinical examination for simultaneous signs of connective tissue weakness and counselling prior to pelvic reconstructive surgery could help to increase patients’ compliance with further surgical treatment for hernia.

Proteomics of Uterosacral Ligament Connective Tissue from Women with and without Pelvic Organ Prolapse

2018 ◽  
Vol 13 (4) ◽  
pp. 1800086
Author(s):  
Xiang‐Juan Li ◽  
Hai‐Tao Pan ◽  
Juan‐Juan Chen ◽  
Yi‐Bin Fu ◽  
Min Fang ◽  
...  
Keyword(s):  
Pelvic Organ Prolapse ◽  
Connective Tissue ◽  
Pelvic Organ ◽  
Uterosacral Ligament

Connective tissue alterations in women with pelvic organ prolapse and urinary incontinence

2007 ◽  
Vol 86 (7) ◽  
pp. 882-888 ◽  
Author(s):  
Rafi Suzme ◽  
Onay Yalcin ◽  
Figen Gurdol ◽  
Funda Gungor ◽  
Ayhan Bilir
Keyword(s):  
Urinary Incontinence ◽  
Pelvic Organ Prolapse ◽  
Connective Tissue ◽  
Pelvic Organ ◽  
Tissue Alterations

Collagen Structure Deterioration in the Skin of Patients with Pelvic Organ Prolapse Determined by Atomic Force Microscopy

2015 ◽  
Vol 21 (2) ◽  
pp. 324-333 ◽  
Author(s):  
Svetlana L. Kotova ◽  
Peter S. Timashev ◽  
Anna E. Guller ◽  
Anatoly B. Shekhter ◽  
Pavel I. Misurkin ◽  
...  
Keyword(s):  
Atomic Force Microscopy ◽  
Pelvic Organ Prolapse ◽  
Connective Tissue ◽  
Histological Study ◽  
Pelvic Organ ◽  
Diagnostic Tools ◽  
Pathological Changes ◽  
Significant Deterioration ◽  
Force Microscopy ◽  
Atomic Force

AbstractWe used atomic force microscopy (AFM) to diagnose pathological changes in the extracellular matrix (ECM) of skin connective tissue in patients with pelvic organ prolapse (POP). POP is a common condition affecting women that considerably decreases the patients’ quality of life. Deviations from normal morphology of the skin ECM from patients with POP occur including packing and arrangement of individual collagen fibers and arrangement of collagen fibrils. The nanoindentation study revealed significant deterioration of the mechanical properties of collagen fibril bundles in the skin of POP patients as compared with the skin of healthy subjects. Changes in the skin ECM appeared to correlate well with changes in the ECM of the pelvic ligament tissue associated with POP. AFM data on the ECM structure of normal and pathologically altered connective tissue were in agreement with results of the standard histological study on the same clinical specimens. Thus, AFM and related techniques may serve as independent or complementary diagnostic tools for tracking POP-related pathological changes of connective tissue.

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