Decreased bone mineral density and content in neurofibromatosis type 1: Lowest local values are located in the load-carrying parts of the body

2004 ◽  
Vol 16 (8) ◽  
pp. 928-936 ◽  
Author(s):  
T. Kuorilehto ◽  
M. Pöyhönen ◽  
R. Bloigu ◽  
J. Heikkinen ◽  
K. Väänänen ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Neurofibromatosis Type 1 ◽  
Neurofibromatosis Type ◽  
The Body ◽  
Mineral Density ◽  
Load Carrying

scholarly journals Bone mineral density in children and young adults with neurofibromatosis type 1

2012 ◽  
Vol 19 (6) ◽  
pp. 817-825 ◽  
Author(s):  
Maya B Lodish ◽  
Urania Dagalakis ◽  
Ninet Sinaii ◽  
Ethan Bornstein ◽  
AeRang Kim ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Neurofibromatosis Type 1 ◽  
Plexiform Neurofibroma ◽  
Neurofibromatosis Type ◽  
Whole Body ◽  
Mineral Density ◽  
Bone Mineral Apparent Density ◽  
Total Body

Concern for impaired bone health in children with neurofibromatosis type 1 (NF-1) has led to increased interest in bone densitometry in this population. Our study assessed bone mineral apparent density (BMAD) and whole-body bone mineral content (BMC)/height in pediatric patients with NF-1 with a high plexiform neurofibroma burden. Sixty-nine patients with NF-1 (age range 5.2–24.8; mean 13.7±4.8 years) were studied. Hologic dual-energy X-ray absorptiometry scans (Hologic, Inc., Bedford, MA, USA) were performed on all patients. BMD was normalized to derive a reference volume by correcting for height through the use of the BMAD, as well as the BMC. BMAD of the lumbar spine (LS 2–4), femoral neck (FN), and total body BMC/height were measured and Z-scores were calculated. Impaired bone mineral density was defined as a Z-score ≤−2. Forty-seven percent of patients exhibited impaired bone mineral density at any bone site, with 36% at the LS, 18% at the FN, and 20% total BMC/height. BMAD Z-scores of the LS (−1.60±1.26) were more impaired compared with both the FN (−0.54±1.58; P=0.0003) and the whole-body BMC/height Z-scores (−1.16±0.90; P=0.036). Plexiform neurofibroma burden was negatively correlated with LS BMAD (rs=−0.36, P=0.01). In pediatric and young adult patients with NF-1, LS BMAD was more severely affected than the FN BMAD or whole-body BMC/height.

Bone Mineral Density in Children With Neurofibromatosis Type 1

2008 ◽  
Vol 28 (7) ◽  
pp. 791-792
Author(s):  
David Little ◽  
Sukhdeep Dulai ◽  
Julie Briody ◽  
Aaron Schinderler ◽  
Kathryn North ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Neurofibromatosis Type 1 ◽  
Neurofibromatosis Type ◽  
Mineral Density

Bone metabolism markers and bone mineral density in children with neurofibromatosis type-1

2008 ◽  
Vol 30 (9) ◽  
pp. 584-588 ◽  
Author(s):  
Ozgur Duman ◽  
Sebahat Ozdem ◽  
Doga Turkkahraman ◽  
Nihal Dundar Olgac ◽  
Firat Gungor ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Metabolism ◽  
Bone Mineral ◽  
Neurofibromatosis Type 1 ◽  
Neurofibromatosis Type ◽  
Mineral Density ◽  
Bone Metabolism Markers

Reduced spinal bone mineral density (BMD) in pre-pubertal children with neurofibromatosis type 1 (NF1)

Bone ◽  
2009 ◽  
Vol 45 ◽  
pp. S68-S69
Author(s):  
J.A. Eelloo ◽  
S.M. Huson ◽  
K.A. Ward ◽  
J.E. Adams ◽  
S.A. Russell ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Neurofibromatosis Type 1 ◽  
Neurofibromatosis Type ◽  
Spinal Bone Mineral Density ◽  
Mineral Density

Decreased Bone Mineral Density in Neurofibromatosis Type 1

2007 ◽  
Vol 27 (4) ◽  
pp. 472-475 ◽  
Author(s):  
Sukhdeep Dulai ◽  
Julie Briody ◽  
Aaron Schindeler ◽  
Kathryn N. North ◽  
Christopher T. Cowell ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Neurofibromatosis Type 1 ◽  
Neurofibromatosis Type ◽  
Mineral Density

Bone Mineral Density in Children With Neurofibromatosis Type 1

2008 ◽  
Vol 28 (7) ◽  
pp. 791 ◽  
Author(s):  
David A. Stevenson ◽  
Mary Murray ◽  
David H. Viskochil ◽  
John C. Carey ◽  
Laurie J. Moyer-Mileur
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Neurofibromatosis Type 1 ◽  
Neurofibromatosis Type ◽  
Mineral Density

scholarly journals Bone Mineral Density in Children and Adolescents with Neurofibromatosis Type 1

2007 ◽  
Vol 150 (1) ◽  
pp. 83-88 ◽  
Author(s):  
David A. Stevenson ◽  
Laurie J. Moyer-Mileur ◽  
Mary Murray ◽  
Hillarie Slater ◽  
Xiaoming Sheng ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Children And Adolescents ◽  
Bone Mineral ◽  
Neurofibromatosis Type 1 ◽  
Neurofibromatosis Type ◽  
Mineral Density

scholarly journals Bone mineral density predictors in long-standing type 1 and type 2 diabetes mellitus

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Stefana Catalina Bilha ◽  
Letitia Leustean ◽  
Cristina Preda ◽  
Dumitru D. Branisteanu ◽  
Laura Mihalache ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Femoral Neck ◽  
Bone Mineral ◽  
Mineral Density ◽  
Cross Sectional ◽  
The Impact

Abstract Background Despite the increased fracture risk, bone mineral density (BMD) is variable in type 1 (T1D) and type 2 (T2D) diabetes mellitus. We aimed at comparing independent BMD predictors in T1D, T2D and control subjects, respectively. Methods Cross-sectional case-control study enrolling 30 T1D, 39 T2D and 69 age, sex and body mass index (BMI) – matched controls that underwent clinical examination, dual-energy X-ray absorptiometry (BMD at the lumbar spine and femoral neck) and serum determination of HbA1c and parameters of calcium and phosphate metabolism. Results T2D patients had similar BMD compared to T1D individuals (after adjusting for age, BMI and disease duration) and to matched controls, respectively. In multiple regression analysis, diabetes duration – but not HbA1c- negatively predicted femoral neck BMD in T1D (β= -0.39, p = 0.014), while BMI was a positive predictor for lumbar spine (β = 0.46, p = 0.006) and femoral neck BMD (β = 0.44, p = 0.007) in T2D, besides gender influence. Age negatively predicted BMD in controls, but not in patients with diabetes. Conclusions Long-standing diabetes and female gender particularly increase the risk for low bone mass in T1D. An increased body weight partially hinders BMD loss in T2D. The impact of age appears to be surpassed by that of other bone regulating factors in both T1D and T2D patients.

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