scholarly journals Further reductions in nonvertebral fracture rate with long-term denosumab treatment in the FREEDOM open-label extension and influence of hip bone mineral density after 3 years

2015 ◽  
Vol 26 (12) ◽  
pp. 2763-2771 ◽  
Author(s):  
S. Ferrari ◽  
J. D. Adachi ◽  
K. Lippuner ◽  
C. Zapalowski ◽  
P. D. Miller ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Nonvertebral Fracture ◽  
Fracture Rate ◽  
Mineral Density ◽  
Open Label ◽  
Open Label Extension ◽  
Denosumab Treatment

scholarly journals Relationship Between Bone Mineral Density T ‐Score and Nonvertebral Fracture Risk Over 10 Years of Denosumab Treatment

2019 ◽  
Vol 34 (6) ◽  
pp. 1033-1040 ◽  
Author(s):  
S Ferrari ◽  
C Libanati ◽  
Celia Jow Fang Lin ◽  
JP Brown ◽  
F Cosman ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Fracture Risk ◽  
Bone Mineral ◽  
Nonvertebral Fracture ◽  
Mineral Density ◽  
T Score ◽  
Denosumab Treatment

Persistent improvement of bone mineral density up to 20 years after treatment of Cushing’s syndrome.

2021 ◽  
Author(s):  
Pepijn van Houten ◽  
Romana Netea-Maier ◽  
Margreet Wagenmakers ◽  
Sean Roerink ◽  
Ad Hermus ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Cushing's Syndrome ◽  
Fracture Rate ◽  
Mineral Density ◽  
Duration Of Symptoms ◽  
Younger Age ◽  
Z Scores ◽  
Male Sex

Objective: Cushing’s syndrome (CS) is associated with osteoporosis and high fracture risk. Besides males sex it is unknown which variables influence bone mineral density (BMD) at diagnosis and it is unclear to what extent BMD normalizes during long-term follow-up after treatment of CS. The aim of this study was to determine factors associated with BMD at diagnosis of CS and to determine the long-term course of BMD and fracture rate after successful treatment of CS. Design: Retrospective cross-sectional and longitudinal cohort study. Methods: Data were collected from 231 patients with CS who were treated at the Radboud University Medical Centre between 1968 and 2020. Results: At diagnosis, male sex was associated with lower Z-scores at the lumbar spine (LS) compared with female sex: -0.97SD [-1.45 - -0.49] after correction for possible confounders. Shorter duration of symptoms and younger age were also associated with lower Z-scores at diagnosis, while etiology of CS, urinary cortisol excretion and gonadal status were not associated with Z-scores at diagnosis. Z-scores improved up to 20 years after treatment. Fifteen years after treatment, men showed larger improvements of Z-scores than women; +2.56 [1.82-3.30] increase in LS Z-score versus +1.48 [0.96-2.00] respectively. Fracture incidence was highest during the 2 years before diagnosis and decreased after treatment. Conclusion: Male sex, younger age and shorter duration of symptoms are associated with lower BMD at diagnosis of CS. BMD continues to improve up to 20 years after treatment of CS. Fracture rate decreases after treatment of CS.

Bone Mineral Density Changes After 1 Year of Denosumab Discontinuation in Postmenopausal Women with Long-Term Denosumab Treatment for Osteoporosis

2018 ◽  
Vol 103 (1) ◽  
pp. 50-54 ◽  
Author(s):  
Albrecht Werner Popp ◽  
Nadshathra Varathan ◽  
Helene Buffat ◽  
Christoph Senn ◽  
Romain Perrelet ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Mineral Density ◽  
Denosumab Treatment

Abstract #880: Greater Increases in Bone Mineral Density Do Not Relate to Greater Decreases in Nonvertebral Fracture Risk

2005 ◽  
Vol 11 ◽  
pp. 47
Author(s):  
Nelson B. Watts ◽  
Piet Geusens ◽  
Ian P. Barton ◽  
Dieter Felsenberg
Keyword(s):  
Bone Mineral Density ◽  
Fracture Risk ◽  
Bone Mineral ◽  
Nonvertebral Fracture ◽  
Mineral Density

Determinants of bone mineral density in long-term adult survivors of childhood cancer

2013 ◽  
Author(s):  
C Klap B ◽  
L te Winkel M ◽  
den Hoed M ◽  
van Waas M ◽  
J C M M Neggers S ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Childhood Cancer ◽  
Bone Mineral ◽  
Adult Survivors ◽  
Mineral Density ◽  
Survivors Of Childhood Cancer
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