Long-Term Fracture Risk Following Ischemic Stroke: A Population-Based Study

2001 ◽  
Vol 12 (11) ◽  
pp. 980-986 ◽  
Author(s):  
L. J. Melton III ◽  
R. D. Brown Jr ◽  
S. J. Achenbach ◽  
W. M. O'Fallon ◽  
J. P. Whisnant ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Fracture Risk ◽  
Population Based ◽  
Population Based Study

Long-Term Fracture Risk Among Children With Asthma: A Population-Based Study

2004 ◽  
Vol 20 (4) ◽  
pp. 564-570 ◽  
Author(s):  
L Joseph Melton ◽  
Ashok Patel ◽  
Sara J Achenbach ◽  
Ann L Oberg ◽  
John W Yunginger
Keyword(s):  
Fracture Risk ◽  
Population Based ◽  
Population Based Study ◽  
Children With Asthma

Abstract 2145: The Long-term Trajectory Of Functional Decline Before And After Stroke: The Northern Manhattan Study

Stroke ◽  
2012 ◽  
Vol 43 (suppl_1) ◽  
Author(s):  
Mandip Dhamoon ◽  
Yeseon P Moon ◽  
Myunghee C Paik ◽  
Consuelo McLaughlin-Mora ◽  
Ralph L Sacco ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Functional Status ◽  
Functional Decline ◽  
Population Based ◽  
Insurance Status ◽  
Population Based Study ◽  
Before And After ◽  
Over Time

Background: Previous research in our population showed a steeper long-term decline in functional status after first ischemic stroke among those with Medicaid or no insurance compared to those with Medicare or private insurance. With only post-stroke data, it was unknown whether these findings were caused by the stroke. We sought to compare the long-term trajectory of functional status before and after ischemic stroke. Methods: The Northern Manhattan Study contains a prospective, population-based study of stroke-free individuals >40 years of age, followed for a median of 10 years. The Barthel index (BI) was assessed annually. Generalized estimating equations were used to assess functional decline over time before and after stroke. The 6 months after stroke were ignored, since the course of recovery during this period is well documented, and our interest was the long-term course of functional status. Follow-up was censored at the time of recurrent stroke. Sociodemographic and medical risk factors were included and results were stratified by insurance status. Linearity of the curves was evaluated by plotting residuals against time and with a lowess curve. Results: Among 3298 participants, 261 had an ischemic stroke during follow-up, of which 51 died within 6 months of stroke. Among the remaining 210 participants, mean age at stroke (standard deviation) was 77+9 years, 38% were male, 52% were Hispanic, 37% had diabetes, and 31% had coronary artery disease. There was no difference in functional decline over time before and after stroke (p= 0.51), with a decline of 0.96 BI points per year before stroke (p<.0001) and 1.24 after stroke (p=0.001). However, when stratified by insurance status, among those with Medicaid or no insurance, in a fully adjusted model, there was a difference in slope before and after stroke (p=0.04), with a decline of 0.58 BI points per year before stroke (p=0.02) and 1.94 after stroke (p=0.001). Other predictors of worse functional status were increasing age, female sex, diabetes, and being married. Conclusion: In this large, prospective, population-based study with long-term follow-up, there was a significantly steeper decline in functional status after ischemic stroke compared to before stroke among those with Medicaid or no insurance, after adjusting for confounders. The cause of this differential decline is not known but may be related to poor control of risk factors, silent strokes, or an effect of socioeconomic status.

Long-term fracture risk in patients with Crohn's disease: A population-based study in Olmsted County, Minnesota

2002 ◽  
Vol 123 (2) ◽  
pp. 468-475 ◽  
Author(s):  
Edward V. Loftus ◽  
Cynthia S. Crowson ◽  
William J. Sandborn ◽  
William J. Tremaine ◽  
William M. O'Fallon ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Fracture Risk ◽  
Population Based ◽  
Olmsted County ◽  
Population Based Study

scholarly journals Seizures Following Ischemic Stroke: Frequency of Occurrence and Impact on Outcome in a Long-Term Population-Based Study

2016 ◽  
Vol 25 (1) ◽  
pp. 150-156 ◽  
Author(s):  
Tomas Bryndziar ◽  
Petra Sedova ◽  
Neha M. Kramer ◽  
Jay Mandrekar ◽  
Robert Mikulik ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Population Based ◽  
Frequency Of Occurrence ◽  
Population Based Study ◽  
Stroke Frequency

Long-term fracture risk following renal transplantation: a population-based study

2003 ◽  
Vol 15 (2) ◽  
pp. 160-167 ◽  
Author(s):  
Line M. Vautour ◽  
L. Joseph Melton ◽  
Bart L. Clarke ◽  
Sara J. Achenbach ◽  
Ann L. Oberg ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Fracture Risk ◽  
Population Based ◽  
Population Based Study

scholarly journals Long-term Fracture Risk in Patients with Celiac Disease: A Population-Based Study in Olmsted County, Minnesota

2007 ◽  
Vol 53 (4) ◽  
pp. 964-971 ◽  
Author(s):  
Mohammed R. Jafri ◽  
Charles W. Nordstrom ◽  
Joseph A. Murray ◽  
Carol T. Van Dyke ◽  
Ross A. Dierkhising ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Fracture Risk ◽  
Population Based ◽  
Olmsted County ◽  
Population Based Study

Long-term fracture risk following adult-onset asthma: a population-based study

2004 ◽  
Vol 15 (4) ◽  
pp. 311-316 ◽  
Author(s):  
L. Joseph Melton, ◽  
Ashok Patel ◽  
Sara J. Achenbach ◽  
Ann L. Oberg ◽  
John W. Yunginger
Keyword(s):  
Fracture Risk ◽  
Population Based ◽  
Adult Onset ◽  
Population Based Study

No relation between biomarkers at age 47–49 and aortic diameter after 14–19 years of follow-up – a population-based study

VASA ◽  
2017 ◽  
Vol 46 (4) ◽  
pp. 291-295 ◽  
Author(s):  
Soumia Taimour ◽  
Moncef Zarrouk ◽  
Jan Holst ◽  
Olle Melander ◽  
Gunar Engström ◽  
...  
Keyword(s):  
Population Based ◽  
Aortic Diameter ◽  
Aortic Dilatation ◽  
Population Based Study ◽  
Reactive Protein ◽  
Abdominal Aortic ◽  
Long Term Follow Up ◽  
Old Men

Abstract. Background: Biomarkers reflecting diverse pathophysiological pathways may play an important role in the pathogenesis of abdominal aortic aneurysm (aortic diameter ≥30 mm, AAA), levels of many biomarkers are elevated and correlated to aortic diameter among 65-year-old men undergoing ultrasound (US) screening for AAA. Probands and methods: To evaluate potential relationships between biomarkers and aortic dilatation after long-term follow-up, levels of C-reactive protein (CRP), proneurotensin (PNT), copeptin (CPT), lipoprotein-associated phospholipase 2 (Lp-PLA2), cystatin C (Cyst C), midregional proatrial natriuretic peptide (MR-proANP), and midregional proadrenomedullin (MR-proADM) were measured in 117 subjects (114 [97 %] men) aged 47–49 in a prospective population-based cohort study, and related to aortic diameter at US examination of the aorta after 14–19 years of follow-up. Results: Biomarker levels at baseline did not correlate with aortic diameter after 14–19 years of follow up (CRP [r = 0.153], PNT [r = 0.070], CPT [r = –.156], Lp-PLA2 [r = .024], Cyst C [r = –.015], MR-proANP [r = 0.014], MR-proADM [r = –.117]). Adjusting for age and smoking at baseline in a linear regression model did not reveal any significant correlations. Conclusions: Tested biomarker levels at age 47–49 were not associated with aortic diameter at ultrasound examination after 14–19 years of follow-up. If there are relationships between these biomarkers and aortic dilatation, they are not relevant until closer to AAA diagnosis.

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