Genetic evidence for involvement of the alternative sigma factor SigI in controlling expression of the cell wall hydrolase gene lytE and contribution of LytE to heat survival of Bacillus subtilis

2011 ◽  
Vol 193 (9) ◽  
pp. 677-685 ◽  
Author(s):  
Chi-Ling Tseng ◽  
Jung-Tze Chen ◽  
Ju-Hui Lin ◽  
Wan-Zhen Huang ◽  
Gwo-Chyuan Shaw
Keyword(s):  
Cell Wall ◽  
Bacillus Subtilis ◽  
Sigma Factor ◽  
Genetic Evidence ◽  
Alternative Sigma Factor ◽  
Cell Wall Hydrolase

scholarly journals Nucleotide sequence and regulation of a new putative cell wall hydrolase gene, cwlD, which affects germination in Bacillus subtilis. .

1995 ◽  
Vol 177 (19) ◽  
pp. 5582-5589 ◽  
Author(s):  
J Sekiguchi ◽  
K Akeo ◽  
H Yamamoto ◽  
F K Khasanov ◽  
J C Alonso ◽  
...  
Keyword(s):  
Cell Wall ◽  
Bacillus Subtilis ◽  
Nucleotide Sequence ◽  
Cell Wall Hydrolase

scholarly journals SweC and SweD are essential co-factors of the FtsEX-CwlO cell wall hydrolase complex in Bacillus subtilis

PLoS Genetics ◽  
2019 ◽  
Vol 15 (8) ◽  
pp. e1008296 ◽  
Author(s):  
Yannick R. Brunet ◽  
Xindan Wang ◽  
David Z. Rudner
Keyword(s):  
Cell Wall ◽  
Bacillus Subtilis ◽  
Cell Wall Hydrolase

scholarly journals Evidence that RpoS (σS) in Borrelia burgdorferi Is Controlled Directly by RpoN (σ54/σN)

2006 ◽  
Vol 189 (5) ◽  
pp. 2139-2144 ◽  
Author(s):  
Alexandra H. Smith ◽  
Jon S. Blevins ◽  
Gulnaz N. Bachlani ◽  
Xiaofeng F. Yang ◽  
Michael V. Norgard
Keyword(s):  
Borrelia Burgdorferi ◽  
Virulence Factors ◽  
Sigma Factor ◽  
Genetic Evidence ◽  
Alternative Sigma Factor

ABSTRACT The alternative sigma factor (RpoN-RpoS) pathway controls the expression of key virulence factors in Borrelia burgdorferi. However, evidence to support whether RpoN controls rpoS directly or, perhaps, indirectly via a transactivator has been lacking. Herein we provide biochemical and genetic evidence that RpoN directly controls rpoS in B. burgdorferi.

scholarly journals Role of autoregulation and relative synthesis of operon partners in alternative sigma factor networks

2015 ◽  
Author(s):  
Jatin Narula ◽  
Abhinav Tiwari ◽  
Oleg A. Igoshin
Keyword(s):  
Bacillus Subtilis ◽  
Stress Response ◽  
Negative Feedback ◽  
Sigma Factor ◽  
Critical Role ◽  
Sigma Factors ◽  
Alternative Sigma Factor ◽  
Negative Feedback Regulation ◽  
Alternative Sigma Factors

SummaryDespite the central role of alternative sigma factors in bacterial stress response and virulence their regulation remains incompletely understood. Here we investigate one of the best-studied examples of alternative sigma factors: the σBnetwork that controls the general stress response ofBacillus subtilisto uncover widely relevant general design principles that describe the structure-function relationship of alternative sigma factor regulatory networks. We show that the relative stoichiometry of the synthesis rates of σB, its anti-sigma factor RsbW and the anti-anti-sigma factor RsbV plays a critical role in shaping the network behavior by forcing the σBnetwork to function as an ultrasensitive negative feedback loop. We further demonstrate how this negative feedback regulation insulates alternative sigma factor activity from competition with the housekeeping sigma factor for RNA polymerase and allows multiple stress sigma factors to function simultaneously with little competitive interference.Major Subject Areas:Computational and systems biology, Microbiology & Infectious diseaseResearch Organism:Bacillus subtilis

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