Avian transgenerational reproductive toxicity test with in ovo exposure

2006 ◽  
Vol 80 (12) ◽  
pp. 846-856 ◽  
Author(s):  
Ryo Kamata ◽  
Shinji Takahashi ◽  
Akira Shimizu ◽  
Fujio Shiraishi
Keyword(s):  
Toxicity Test ◽  
Reproductive Toxicity ◽  
In Ovo

Development and validation of an OECD reproductive toxicity test guideline with the pond snail Lymnaea stagnalis (Mollusca, Gastropoda)

2014 ◽  
Vol 70 (3) ◽  
pp. 605-614 ◽  
Author(s):  
Virginie Ducrot ◽  
Clare Askem ◽  
Didier Azam ◽  
Denise Brettschneider ◽  
Rebecca Brown ◽  
...  
Keyword(s):  
Toxicity Test ◽  
Lymnaea Stagnalis ◽  
Reproductive Toxicity ◽  
Pond Snail ◽  
Development And Validation ◽  
Test Guideline

Nanoparticle Delivery Systems Reduce the Reproductive Toxicity of Docetaxel in Rodents

Nano LIFE ◽  
2014 ◽  
Vol 04 (04) ◽  
pp. 1441012 ◽  
Author(s):  
Lijiang Zhang ◽  
Yongguang Yang ◽  
Yisheng Song ◽  
Hongzhong Yang ◽  
Guoliang Zhou ◽  
...  
Keyword(s):  
Toxicity Test ◽  
Developmental Toxicity ◽  
Reproductive Toxicity ◽  
Delivery Systems ◽  
Early Embryo ◽  
Female Rat ◽  
Pharmacological Effects ◽  
Nanoparticle Delivery ◽  
Sperm Abnormality ◽  
Histopathology Examination

Various docetaxel (DTX)-loaded nanoparticle delivery systems have been designed to enhance the solubility and pharmacological effects of DTX. However, the toxicity changes of these nano-modified DTX (nano-DTX) are not yet clear enough. Herein, to compare the reproductive toxicity between conventional DTX and nano-DTX, we performed sperm toxicity test in mice, and fertility and early embryo-fetal developmental toxicity test in rats. It was found that DTX severely repressed spermatogenesis and sperm motility, and dramatically increased sperm abnormality in mice and rats. Moreover, DTX significantly decreased copulation, conception and fertility indexes in rats, and no positive pregnant female rat was obtained after treatment with DTX. However, nano-DTX significantly reduced DTX-induced toxicity to sperm. Most importantly, nano-DTX obviously converted DTX-induced fertility and early embryo-fetal developmental toxicity. Furthermore, organ weights and histopathology examination revealed DTX, but not nano-DTX, significantly decreased testis and epididymis weights, and induced obvious histopathological atrophy of testes and epididymides in rats. Further studies indicated that changed activity of lactate dehydrogenase C4 (LDH-C4) in rodents testes was mainly responsible for the above observations. These results strongly support the idea that DTX-loaded nanoformulations have the potential to overcome the reproductive toxicity of DTX.

Reproductive Toxicity Test

2017 ◽  
Author(s):  
John H. Duffus ◽  
Michael Schwenk ◽  
Douglas M. Templeton
Keyword(s):  
Toxicity Test ◽  
Reproductive Toxicity

scholarly journals Development and validation of an OECD reproductive toxicity test guideline with the mudsnail Potamopyrgus antipodarum (Mollusca, Gastropoda)

Chemosphere ◽  
2017 ◽  
Vol 181 ◽  
pp. 589-599 ◽  
Author(s):  
Katharina Ruppert ◽  
Cornelia Geiß ◽  
Clare Askem ◽  
Rachel Benstead ◽  
Rebecca Brown ◽  
...  
Keyword(s):  
Toxicity Test ◽  
Reproductive Toxicity ◽  
Potamopyrgus Antipodarum ◽  
Development And Validation ◽  
Test Guideline

An extended one-generation reproductive toxicity test of 1,2,4-Triazol-5-one (NTO) in rats

2016 ◽  
Vol 79 (24) ◽  
pp. 1159-1178 ◽  
Author(s):  
Emily May Lent ◽  
Lee C. B. Crouse ◽  
Allison M. Jackovitz ◽  
Erica E. Carroll ◽  
Mark S. Johnson
Keyword(s):  
Toxicity Test ◽  
Reproductive Toxicity

Hexachlorobenzene toxicity in the monkey ovary: III. Ultrastructure induced by high (10 mg/kg) dose exposure

1991 ◽  
Vol 49 ◽  
pp. 130-131
Author(s):  
A. Singh ◽  
A. Dykeman ◽  
J. Jarrelf ◽  
D. C. Villeneuve
Keyword(s):  
Present Report ◽  
Reproductive Toxicity ◽  
Control Group ◽  
Primate Model ◽  
Human Follicular Fluid ◽  
Thin Sections ◽  
Cynomolgus Monkeys ◽  
Cacodylate Buffer ◽  
Induction Cycle ◽  
Comprehensive Study

Hexachlorobenzene (HCB), a persistent and mobile organochlorine pesticide, occurs in environment. HCB has been shown to be present in human follicular fluid. An objective of the present report, which is part of a comprehensive study on reproductive toxicity of HCB, was to determine the cytologic effects of the compound on ovarian follicles in a primate model.Materials and Methods. Eight Cynomolgus monkeys were housed under controlled conditions at Animal facility of Health and Welfare, Ottawa. Animals were orally administered gelatin capsules containing HCB mixed with glucose in daily dosages of 0.0 or 10 mg/kg b.w. for 90 days; the former was the control group. On the menstrual period following completion of dosing, the monkeys underwent an induction cycle of superovulation. At necropsy, one-half of an ovary from each animal was diced into ca. 2- to 3-mm cubed specimens that were fixed by immersion in 2.5% glutaraldehyde in 0.1 M cacodylate buffer (pH 7.3). Subsequent procedures followed to obtain thin sections that were examined in a Hitachi H-7000 electron microscope have been described earlier.

Effects of carbamylcholine on chick embryo aggregate retina cell cultures

1988 ◽  
Vol 46 ◽  
pp. 350-351
Author(s):  
Glenn M. Cohen ◽  
Radharaman Ray
Keyword(s):  
Cell Cultures ◽  
Single Cells ◽  
Retinal Cell ◽  
Cell Aggregates ◽  
High Concentration ◽  
In Ovo ◽  
Sterile Culture ◽  
Retinal Tissue ◽  
Synaptic Junctions ◽  
And Control

Retinal,cell aggregates develop in culture in a pattern similar to the in ovo retina, forming neurites first and then synapses. In the present study, we continuously exposed chick retinal cell aggregates to a high concentration (1 mM) of carbamylcholine (carbachol), an acetylcholine (ACh) analog that resists hydrolysis by acetylcholinesterase (AChE). This situation is similar to organophosphorus anticholinesterase poisoning in which the ACh level is elevated at synaptic junctions due to inhibition of AChE, Our objective was to determine whether continuous carbachol exposure either damaged cholino- ceptive neurites, cell bodies, and synaptic elements of the aggregates or influenced (hastened or retarded) their development.The retinal tissue was isolated aseptically from 11 day embryonic White Leghorn chicks and then enzymatically (trypsin) and mechanically (trituration) dissociated into single cells. After washing the cells by repeated suspension and low (about 200 x G) centrifugation twice, aggregate cell cultures (about l0 cells/culture) were initiated in 1.5 ml medium (BME, GIBCO) in 35 mm sterile culture dishes and maintained as experimental (containing 10-3 M carbachol) and control specimens.

103. Multi-Generation Reproductive Toxicity Study of Implanted Depleted Uranium in Rats

2004 ◽  
Author(s):  
D. Arfsten ◽  
A. Thitoff ◽  
E. Johnson ◽  
A. Jung ◽  
W. Jederberg ◽  
...  
Keyword(s):  
Reproductive Toxicity ◽  
Depleted Uranium ◽  
Toxicity Study
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