Verapamil exerts biphasic modulation on phenobarbital transport across the blood–brain barrier: evidence from an in vivo and in vitro study

2011 ◽  
Vol 383 (4) ◽  
pp. 393-402 ◽  
Author(s):  
Dan Yao ◽  
Zhi-Hong Yang ◽  
Li Liu ◽  
Jia Li ◽  
Yun-Li Yu ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
In Vitro Study ◽  
Vitro Study ◽  
Brain Barrier ◽  
Blood Brain

scholarly journals TRANSPORT MECHANISM OF TOLBUTAMIDE ACROSS THE BLOOD-BRAIN BARRIER -Analysis of In Vivo-In Vitro Study-

1997 ◽  
Vol 12 (supplement) ◽  
pp. 78-79
Author(s):  
Hitomi TAKANAGA ◽  
Noriko KOYABU ◽  
Hideyasu MURAKAMI ◽  
Hirotami MATSUO ◽  
Mikihiko NAITO ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Transport Mechanism ◽  
In Vitro Study ◽  
Vitro Study ◽  
Brain Barrier ◽  
Barrier Analysis ◽  
Blood Brain

scholarly journals In Vitro Study of the Effects of Angiostrongylus cantonensis Larvae Extracts on Apoptosis and Dysfunction in the Blood-Brain Barrier (BBB)

PLoS ONE ◽  
2012 ◽  
Vol 7 (2) ◽  
pp. e32161 ◽  
Author(s):  
Xin Hu ◽  
Jiang-Hui Li ◽  
Lan Lan ◽  
Fei-Fei Wu ◽  
Er-Peng Zhang ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
In Vitro Study ◽  
Angiostrongylus Cantonensis ◽  
Vitro Study ◽  
Brain Barrier ◽  
Blood Brain

scholarly journals In Vitro Study of Receptor-Mediated Silica Nanoparticles Delivery across Blood–Brain Barrier

2017 ◽  
Vol 9 (24) ◽  
pp. 20410-20416 ◽  
Author(s):  
Yang Song ◽  
Dan Du ◽  
Lei Li ◽  
Jun Xu ◽  
Prashanta Dutta ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Blood Brain Barrier ◽  
In Vitro Study ◽  
Vitro Study ◽  
Brain Barrier ◽  
Blood Brain

scholarly journals Nanoparticles Based on Quaternary Ammonium Chitosan-methyl-β-cyclodextrin Conjugate for the Neuropeptide Dalargin Delivery to the Central Nervous System: An In Vitro Study

Pharmaceutics ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 5
Author(s):  
Chiara Migone ◽  
Letizia Mattii ◽  
Martina Giannasi ◽  
Stefania Moscato ◽  
Andrea Cesari ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Quaternary Ammonium ◽  
Oral Absorption ◽  
In Vitro Study ◽  
Brain Barrier ◽  
Mucosal Barrier ◽  
Blood Brain ◽  
The Brain

Peptide oral administration is a hard goal to reach, especially if the brain is the target site. The purpose of the present study was to set up a vehicle apt to promote oral absorption of the neuropeptide dalargin (DAL), allowing it to cross the intestinal mucosal barrier, resist enzymatic degradation, and transport drugs to the brain after crossing the blood–brain barrier. Therefore, a chitosan quaternary ammonium derivative was synthesized and conjugated with methyl-β-cyclodextrin to prepare DAL-medicated nanoparticles (DAL-NP). DAL-NP particle size was 227.7 nm, zeta potential +8.60 mV, encapsulation efficiency 89%. DAL-NP protected DAL from degradation by chymotrypsin or pancreatin and tripled DAL degradation time compared to non-encapsulated DAL. Use of DAL-NP was safe for either Caco-2 or bEnd.3 cells, with the latter selected as a blood–brain barrier model. DAL-NP could also cross either the Caco-2 or bEnd.3 monolayer by the transepithelial route. The results suggest a potential DAL-NP ability to transport to the brain a DAL dose fraction administered orally, although in vivo experiments will be needed to confirm the present data obtained in vitro.

Blood-brain barrier destruction determines Fisher/Bickerstaff clinical phenotypes: an in vitro study

2013 ◽  
Vol 84 (7) ◽  
pp. 756-765 ◽  
Author(s):  
K. Saito ◽  
F. Shimizu ◽  
M. Koga ◽  
Y. Sano ◽  
A. Tasaki ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
In Vitro Study ◽  
Vitro Study ◽  
Brain Barrier ◽  
Clinical Phenotypes ◽  
Blood Brain

In vitro study of transportation of porphyrin immobilized graphene oxide through blood brain barrier

2020 ◽  
Vol 107 ◽  
pp. 110313 ◽  
Author(s):  
Siheng Su ◽  
Jilong Wang ◽  
Jingjing Qiu ◽  
Raul Martinez-Zaguilan ◽  
Souad R. Sennoune ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Blood Brain Barrier ◽  
In Vitro Study ◽  
Vitro Study ◽  
Brain Barrier ◽  
Blood Brain

Radiation-induced blood–brain barrier damages: An in vitro study

2012 ◽  
Vol 1433 ◽  
pp. 114-126 ◽  
Author(s):  
William Fauquette ◽  
Christine Amourette ◽  
Marie-Pierre Dehouck ◽  
Michel Diserbo
Keyword(s):  
Blood Brain Barrier ◽  
In Vitro Study ◽  
Vitro Study ◽  
Brain Barrier ◽  
Blood Brain ◽  
Radiation Induced
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