Protective role of simvastatin on isolated rabbit atrioventricular node during experimental atrial fibrillation model: role in rate control of ventricular beats

2012 ◽  
Vol 385 (7) ◽  
pp. 697-706 ◽  
Author(s):  
Vahid Khori ◽  
Soroosh Aminolsharieh Najafi ◽  
Ali Mohammad Alizadeh ◽  
Hamid Reza Moheimani ◽  
Delaram Shakiba ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Rate Control ◽  
Atrioventricular Node ◽  
Protective Role

scholarly journals PROGNOSTIC ROLE OF ATRIAL FIBRILLATION AND HEART RATE CONTROL IN CHRONIC HEART FAILURE PATIENTS

2013 ◽  
Vol 61 (10) ◽  
pp. E735
Author(s):  
Savina Nodari ◽  
Marco Triggiani ◽  
Laura Lupi ◽  
Alessandra Manerba ◽  
Giuseppe Milesi ◽  
...  
Keyword(s):  
Heart Failure ◽  
Atrial Fibrillation ◽  
Heart Rate ◽  
Chronic Heart Failure ◽  
Rate Control ◽  
Heart Rate Control ◽  
Prognostic Role ◽  
Heart Failure Patients

Protective Role of Medications on Atrial Fibrillation and Heart Failure with Preserved Ejection Fraction

2014 ◽  
Vol 20 (8) ◽  
pp. S121
Author(s):  
Arnav Kumar ◽  
Amarpreet K. Saluja ◽  
Adnan Khan ◽  
Mohammad Morsy ◽  
Wissam I. Khalife
Keyword(s):  
Heart Failure ◽  
Atrial Fibrillation ◽  
Ejection Fraction ◽  
Protective Role ◽  
Preserved Ejection Fraction

scholarly journals Atrial fibrillation ablation in heart failure

2020 ◽  
Vol 22 (Supplement_E) ◽  
pp. E50-E53
Author(s):  
Cristina Balla ◽  
Riccardo Cappato
Keyword(s):  
Heart Failure ◽  
Atrial Fibrillation ◽  
Control Strategy ◽  
Rate Control ◽  
Pharmacological Therapy ◽  
Rhythm Control ◽  
Invasive Approach ◽  
Normal Cardiac Function

Abstract Atrial fibrillation (AF) and heart failure (HF) commonly coexist in the same patient and either condition predisposes to the other. Several mechanisms promote the pathophysiological relationship between AF and HF, reducing quality of life, increasing the risk of stroke, and worsening HF progression. Although restoration and maintenance of sinus rhythm would be ideal for those patients, several trials comparing rhythm and rate control failed to show a benefit of rhythm control strategy, achieved with pharmacological therapy, in terms of hospitalization for HF or death. Catheter ablation is a well-established option for symptomatic AF patients, resistant to drug therapy, with normal cardiac function. Several recent studies have shown an improvement in clinical outcomes after AF ablation in HF patients highlighting the emerging role of the invasive approach in this subset of patients. However, several concerns regarding patients’ selection and standardization of the procedure still remain to be addressed.

scholarly journals A case of atrioventricular junction ablation and permanent left bundle branch pacing for patient with refractory atrial fibrillation and hypertrophic cardiomyopathy

2020 ◽  
Author(s):  
Ning Zhang ◽  
Shan Liu ◽  
Shou Zhang ◽  
Yan Wei ◽  
Le Xie ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Hypertrophic Cardiomyopathy ◽  
Rate Control ◽  
Atrioventricular Node ◽  
Clinical Effectiveness ◽  
Atrioventricular Junction ◽  
His Bundle ◽  
Pace Maker

Atrioventricular node ablation (AVNA) combined with His bundle pacing (HBP) are feasible, safe, and effective in patients with refractory atrial fibrillation (AF), however, the pacing parameters of sensing and capture threshold maybe sometimes unsatisfactory. Left bundle branch pacing (LBBP) provides obvious advantage in patients with conduction diseases at the distal His bundle for its better sensing, a lower and more stable capture threshold. Among hypertrophic cardiomyopathy (HCM) patients, AF is a common sustained arrhythmia, primarily caused by left atrial dilatation and remodeling. Few is known about the feasibility of electrophysiological performance, safety and clinical effectiveness of atrioventricular junction ablation (AVJA) combined with LBBP in patient with refractory AF and HCM. Here, we report a case of a 56-year-old woman suffering from refractory AF and HCM, however HBP was failed for its unsatisfactory sensing, a high and unstable capture threshold for her, therefore, ablation and LBBB were accepted by her to achieve better rate control. Improvement in symptoms, quality of life, and exercise capacity has been observed during the 1.5-year follow-up. To our knowledge, our case originally confirmed that the combination of AVJA and LBBP, without the defect of AVNA combined with HBP, is a better strategy with feasibility and safety for refractory AF patients with comorbidity of HCM, additionally, it may make LBBP more applicable and valuable among patients suffering from HCM meanwhile pace maker treatments are essential.

Rate control: medical therapy

ESC CardioMed ◽  
2018 ◽  
pp. 2155-2159
Author(s):  
Isabelle C. Van Gelder ◽  
Michiel Rienstra ◽  
Laurent Pison ◽  
Harry J. G. M. Crijns
Keyword(s):  
Atrial Fibrillation ◽  
Heart Rate ◽  
Rate Control ◽  
Beta Blockers ◽  
Systolic Heart Failure ◽  
Atrioventricular Node ◽  
Channel Blockers ◽  
Control Approach ◽  
Important Message ◽  
Reasonable Choice

Control of the heart rate (rate control) is central to atrial fibrillation management, even for patients who ultimately require control of the rhythm. The choice of rate control depends on symptoms and clinical characteristics of the patient, but for all patients with atrial fibrillation, rate control is part of the management. Choice of drugs is patient dependent and driven by the patient-specific rate–symptom relationship as well as associated conditions. Beta blockers, alone or in combination with digoxin, or non-dihydropyridine calcium channel blockers effectively lower the heart rate. Digoxin is least effective, but a reasonable choice for older, physically inactive patients, in whom other therapies are ineffective or contraindicated, and as an additional drug, especially in systolic heart failure. Institution of all rate control drugs should be performed cautiously. Atrioventricular node ablation with pacemaker insertion for rate control should be the approach of last resort. Catheter ablation of atrial fibrillation, however, should be considered before atrioventricular node ablation. No one formula can integrate the best approach to a specific drug or the effects of therapeutic combinations, but one important message is that a lenient approach to rate control is easy, safe, and effective in many patients and should be considered as the initial approach. A stricter rate control approach is adopted when symptoms persist or deterioration of the left ventricular function occurs. Although rate control is the top priority and one of the first management issues for all patients with atrial fibrillation, and has been studied extensively, many issues remain.

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