scholarly journals Effects of cocaine self-administration history under limited and extended access conditions on in vivo striatal dopamine neurochemistry and acoustic startle in rhesus monkeys

2009 ◽  
Vol 205 (2) ◽  
pp. 237-247 ◽  
Author(s):  
Porche’ Kirkland Henry ◽  
Michael Davis ◽  
Leonard L. Howell
Keyword(s):  
Rhesus Monkeys ◽  
Acoustic Startle ◽  
Striatal Dopamine ◽  
Self Administration ◽  
Extended Access

Effect of cocaine self-administration on striatal dopamine D1 receptors in rhesus monkeys

Synapse ◽  
1998 ◽  
Vol 28 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Rodney J. Moore ◽  
Sharon L. Vinsant ◽  
Michael A. Nader ◽  
Linda J. Porrino ◽  
David P. Friedman
Keyword(s):  
Rhesus Monkeys ◽  
Striatal Dopamine ◽  
D1 Receptors ◽  
Self Administration ◽  
Dopamine D1 Receptors

scholarly journals Antagonism of triazolam self-administration in rhesus monkeys responding under a progressive-ratio schedule: In vivo apparent pA2 analysis

2016 ◽  
Vol 158 ◽  
pp. 22-29 ◽  
Author(s):  
Bradford D. Fischer ◽  
Donna M. Platt ◽  
Sundari K. Rallapalli ◽  
Ojas A. Namjoshi ◽  
James M. Cook ◽  
...  
Keyword(s):  
Rhesus Monkeys ◽  
Progressive Ratio ◽  
Ratio Schedule ◽  
Progressive Ratio Schedule ◽  
Self Administration ◽  
Pa2 Analysis

scholarly journals Corticotropin-releasing factor (CRF) and α2 adrenergic receptors mediate heroin withdrawal-potentiated startle in rats

2013 ◽  
Vol 16 (8) ◽  
pp. 1867-1875 ◽  
Author(s):  
Paula E. Park ◽  
Leandro F. Vendruscolo ◽  
Joel E. Schlosburg ◽  
Scott Edwards ◽  
Gery Schulteis ◽  
...  
Keyword(s):  
Adrenergic Receptors ◽  
Acoustic Startle ◽  
Acoustic Startle Response ◽  
Brain Regions ◽  
Opioid Withdrawal ◽  
Corticotropin Releasing Factor ◽  
Heroin Addiction ◽  
Stress System ◽  
Self Administration ◽  
Extended Access

Abstract Anxiety is one of the early symptoms of opioid withdrawal and contributes to continued drug use and relapse. The acoustic startle response (ASR) is a component of anxiety that has been shown to increase during opioid withdrawal in both humans and animals. We investigated the role of corticotropin-releasing factor (CRF) and norepinephrine (NE), two key mediators of the brain stress system, on acute heroin withdrawal-potentiated ASR. Rats injected with heroin (2 mg/kg s.c.) displayed an increased ASR when tested 4 h after heroin treatment. A similar increase in ASR was found in rats 10–20 h into withdrawal from extended access (12 h) to i.v. heroin self-administration, a model that captures several aspects of heroin addiction in humans. Both the α2 adrenergic receptor agonist clonidine (10 µg/kg s.c.) and CRF1 receptor antagonist N,N-bis(2-methoxyethyl)-3-(4-methoxy-2-methylphenyl)-2,5-dimethyl-pyrazolo[1,5-a] pyrimidin-7-amine (MPZP; 20 mg/kg s.c.) blocked heroin withdrawal-potentiated startle. To investigate the relationship between CRF1 and α2 adrenergic receptors in the potentiation of the ASR, we tested the effect of MPZP on yohimbine (1.25 mg/kg s.c.)-potentiated startle and clonidine on CRF (2 µg i.c.v.)-potentiated startle. Clonidine blocked CRF-potentiated startle, whereas MPZP partially attenuated but did not reverse yohimbine-potentiated startle, suggesting that CRF may drive NE release to potentiate startle. These results suggest that CRF1 and α2 receptors play an important role in the heightened anxiety-like behaviour observed during acute withdrawal from heroin, possibly via CRF inducing the release of NE in stress-related brain regions.

scholarly journals SCH23390 Reduces Methamphetamine Self-Administration and Prevents Methamphetamine-Induced Striatal LTD

2020 ◽  
Vol 21 (18) ◽  
pp. 6491
Author(s):  
Yosef Avchalumov ◽  
Wulfran Trenet ◽  
Juan Piña-Crespo ◽  
Chitra Mandyam
Keyword(s):  
Synaptic Transmission ◽  
Ex Vivo ◽  
Dorsal Striatum ◽  
Long Term Potentiation ◽  
High Frequency Stimulation ◽  
Self Administration ◽  
Striatal Slices ◽  
Extended Access

Extended-access methamphetamine self-administration results in unregulated intake of the drug; however, the role of dorsal striatal dopamine D1-like receptors (D1Rs) in the reinforcing properties of methamphetamine under extended-access conditions is unclear. Acute (ex vivo) and chronic (in vivo) methamphetamine exposure induces neuroplastic changes in the dorsal striatum, a critical region implicated in instrumental learning. For example, methamphetamine exposure alters high-frequency stimulation (HFS)-induced long-term depression in the dorsal striatum; however, the effect of methamphetamine on HFS-induced long-term potentiation (LTP) in the dorsal striatum is unknown. In the current study, dorsal striatal infusion of SCH23390, a D1R antagonist, prior to extended-access methamphetamine self-administration reduced methamphetamine addiction-like behavior. Reduced behavior was associated with reduced expression of PSD-95 in the dorsal striatum. Electrophysiological findings demonstrate that superfusion of methamphetamine reduced basal synaptic transmission and HFS-induced LTP in dorsal striatal slices, and SCH23390 prevented this effect. These results suggest that alterations in synaptic transmission and synaptic plasticity induced by acute methamphetamine via D1Rs could assist with methamphetamine-induced modification of corticostriatal circuits underlying the learning of goal-directed instrumental actions and formation of habits, mediating escalation of methamphetamine self-administration and methamphetamine addiction-like behavior.

scholarly journals Abstinence from Chronic Cocaine Self-Administration Alters Striatal Dopamine Systems in Rhesus Monkeys

2008 ◽  
Vol 34 (5) ◽  
pp. 1162-1171 ◽  
Author(s):  
Thomas J R Beveridge ◽  
Hilary R Smith ◽  
Michael A Nader ◽  
Linda J Porrino
Keyword(s):  
Rhesus Monkeys ◽  
Striatal Dopamine ◽  
Self Administration ◽  
Chronic Cocaine

scholarly journals The effects of nociceptin/orphanin FQ receptor agonist Ro 64-6198 and diazepam on antinociception and remifentanil self-administration in rhesus monkeys

2010 ◽  
Vol 213 (1) ◽  
pp. 53-60 ◽  
Author(s):  
Christopher A. Podlesnik ◽  
Mei-Chuan Ko ◽  
Gail Winger ◽  
Jürgen Wichmann ◽  
Eric P. Prinssen ◽  
...  
Keyword(s):  
Rhesus Monkeys ◽  
Receptor Agonist ◽  
Orphanin Fq ◽  
Self Administration

scholarly journals Parkin regulates drug-taking behavior in rat model of methamphetamine use disorder

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Akhil Sharma ◽  
Arman Harutyunyan ◽  
Bernard L. Schneider ◽  
Anna Moszczynska
Keyword(s):  
Neural Substrates ◽  
Genetically Engineered ◽  
Wild Type ◽  
Therapeutic Approaches ◽  
Self Administration ◽  
Methamphetamine Use ◽  
New Therapeutic Approaches ◽  
Extended Access ◽  
High Doses ◽  
Methamphetamine Use Disorder

AbstractThere is no FDA-approved medication for methamphetamine (METH) use disorder. New therapeutic approaches are needed, especially for people who use METH heavily and are at high risk for overdose. This study used genetically engineered rats to evaluate PARKIN as a potential target for METH use disorder. PARKIN knockout, PARKIN-overexpressing, and wild-type young adult male Long Evans rats were trained to self-administer high doses of METH using an extended-access METH self-administration paradigm. Reinforcing/rewarding properties of METH were assessed by quantifying drug-taking behavior and time spent in a METH-paired environment. PARKIN knockout rats self-administered more METH and spent more time in the METH-paired environment than wild-type rats. Wild-type rats overexpressing PARKIN self-administered less METH and spent less time in the METH-paired environment. PARKIN knockout rats overexpressing PARKIN self-administered less METH during the first half of drug self-administration days than PARKIN-deficient rats. The results indicate that rats with PARKIN excess or PARKIN deficit are useful models for studying neural substrates underlying “resilience” or vulnerability to METH use disorder and identify PARKIN as a novel potential drug target to treat heavy use of METH.

scholarly journals Withdrawal from long-term methamphetamine self-administration ‘normalizes’ neurometabolites in rhesus monkeys: a1H MR spectroscopy study

2013 ◽  
Vol 20 (1) ◽  
pp. 69-79 ◽  
Author(s):  
Shaolin Yang ◽  
Annabelle M. Belcher ◽  
Svetlana Chefer ◽  
D. Bruce Vaupel ◽  
Charles W. Schindler ◽  
...  
Keyword(s):  
Mr Spectroscopy ◽  
Rhesus Monkeys ◽  
Spectroscopy Study ◽  
Self Administration

scholarly journals Effects of Phendimetrazine Treatment on Cocaine vs Food Choice and Extended-Access Cocaine Consumption in Rhesus Monkeys

2013 ◽  
Vol 38 (13) ◽  
pp. 2698-2707 ◽  
Author(s):  
Matthew L Banks ◽  
Bruce E Blough ◽  
Timothy R Fennell ◽  
Rodney W Snyder ◽  
S Stevens Negus
Keyword(s):  
Food Choice ◽  
Rhesus Monkeys ◽  
Extended Access
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