A label-free MALDI TOF MS-based method for studying the kinetics and inhibitor screening of the Alzheimer’s disease drug target β-secretase

2018 ◽  
Vol 410 (28) ◽  
pp. 7441-7448 ◽  
Author(s):  
Markéta Machálková ◽  
Jan Schejbal ◽  
Zdeněk Glatz ◽  
Jan Preisler
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Drug Target ◽  
Label Free ◽  
Maldi Tof Ms ◽  
Inhibitor Screening ◽  
Maldi Tof ◽  
Tof Ms

Copper binding properties of a tau peptide associated with Alzheimer's disease studied by CD, NMR, and MALDI-TOF MS

Peptides ◽  
2006 ◽  
Vol 27 (4) ◽  
pp. 841-849 ◽  
Author(s):  
Qingfeng Ma ◽  
Yanmei Li ◽  
Jintang Du ◽  
Huadong Liu ◽  
Kenji Kanazawa ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Copper Binding ◽  
Binding Properties ◽  
Maldi Tof Ms ◽  
Maldi Tof ◽  
Tof Ms

scholarly journals MALDI-TOF MS as a label-free approach to rapid inhibitor screening

2006 ◽  
Vol 17 (6) ◽  
pp. 815-822 ◽  
Author(s):  
Kenneth D. Greis ◽  
Songtao Zhou ◽  
Thomas M. Burt ◽  
Andrew N. Carr ◽  
Elizabeth Dolan ◽  
...  
Keyword(s):  
Label Free ◽  
Maldi Tof Ms ◽  
Inhibitor Screening ◽  
Maldi Tof ◽  
Tof Ms

scholarly journals Precision enhancement of MALDI-TOF MS using high resolution peak detection and label-free alignment

PROTEOMICS ◽  
2008 ◽  
Vol 8 (8) ◽  
pp. 1530-1538 ◽  
Author(s):  
Maureen B. Tracy ◽  
Haijian Chen ◽  
Dennis M. Weaver ◽  
Dariya I. Malyarenko ◽  
Maciek Sasinowski ◽  
...  
Keyword(s):  
High Resolution ◽  
Peak Detection ◽  
Label Free ◽  
Maldi Tof Ms ◽  
Maldi Tof ◽  
Tof Ms

Measurement of Blood Protease Kinetic Parameters with Self-Assembled Monolayer Ligand Binding Assays and Label-Free MALDI-TOF MS

2013 ◽  
Vol 85 (21) ◽  
pp. 10597-10604 ◽  
Author(s):  
Steven M. Patrie ◽  
Michael J. Roth ◽  
Daniel A. Plymire ◽  
Erica Maresh ◽  
Junmei Zhang
Keyword(s):  
Ligand Binding ◽  
Kinetic Parameters ◽  
Label Free ◽  
Binding Assays ◽  
Self Assembled Monolayer ◽  
Maldi Tof Ms ◽  
Maldi Tof ◽  
Self Assembled ◽  
Tof Ms

Memapsin 2, a drug target for Alzheimer's disease

2003 ◽  
Vol 70 ◽  
pp. 213-220 ◽  
Author(s):  
Gerald Koelsch ◽  
Robert T. Turner ◽  
Lin Hong ◽  
Arun K. Ghosh ◽  
Jordan Tang
Keyword(s):  
Crystal Structure ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Transition State ◽  
Amyloid Precursor Protein ◽  
Therapeutic Target ◽  
Drug Target ◽  
Aspartic Protease ◽  
Precursor Protein ◽  
Memapsin 2

Mempasin 2, a ϐ-secretase, is the membrane-anchored aspartic protease that initiates the cleavage of amyloid precursor protein leading to the production of ϐ-amyloid and the onset of Alzheimer's disease. Thus memapsin 2 is a major therapeutic target for the development of inhibitor drugs for the disease. Many biochemical tools, such as the specificity and crystal structure, have been established and have led to the design of potent and relatively small transition-state inhibitors. Although developing a clinically viable mempasin 2 inhibitor remains challenging, progress to date renders hope that memapsin 2 inhibitors may ultimately be useful for therapeutic reduction of ϐ-amyloid.

895: Proteomic Analysis of Sera from Bladder Cancer Patients with MALDI-TOF-MS

2007 ◽  
Vol 177 (4S) ◽  
pp. 297-297
Author(s):  
Kristina Schwamborn ◽  
Rene Krieg ◽  
Ruth Knüchel-Clarke ◽  
Joachim Grosse ◽  
Gerhard Jakse
Keyword(s):  
Bladder Cancer ◽  
Cancer Patients ◽  
Proteomic Analysis ◽  
Maldi Tof Ms ◽  
Maldi Tof ◽  
Tof Ms
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