Determination of inorganic acids by ion chromatography with n -tetradecylphosphocholine (zwitterionic surfactant) as the stationary phase and pure water as the mobile phase

A simple, rapid and accurate method for the determination of monoethanolamine (MEA) in PHWR steam-water circuits has been developed. MEA is added in the feed water to provide protection against corrosion while hydrazine is added to scavenge dissolved oxygen. The quantitative determination of MEA in presence of hydrazine was accomplished using derivatization ion chromatography with conductometric detection in nonsuppressed mode. A Metrosep cation 1-2 analytical column and a Metrosep cartridge were used for cation separation. A mixture of 4 mM tartaric acid, 20% acetone and 0.05 mM HNO3was used as eluent. Acetone in the mobile phase leads to the formation of different derivatives with MEA and hydrazine. The interferences due Na+and NH4 +were eliminated by adopting a simple pretreatment procedure employing OnGuard-H cartridge. The limit of detection limit of MEA was 0.1 μg mL−1and the relative standard deviation was 2% for the overall method. The recovery of MEA added was in the range 95%–102%. The method was applied to the determination of MEA in steam generator water samples.

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Determination of atmospheric alkylamines by ion chromatography using 18-crown-6 as mobile phase additive

Journal of Chromatography A ◽

10.1016/j.chroma.2018.05.074 ◽

2018 ◽

Vol 1563 ◽

pp. 154-161 ◽

Cited By ~ 3

Author(s):

Shengqian Zhou ◽

Jing Lin ◽

Xiaofei Qin ◽

Ying Chen ◽

Congrui Deng

Keyword(s):

Ion Chromatography ◽

Mobile Phase ◽

Mobile Phase Additive

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Determination of New Antidepressants in Pharmaceuticals by Thin-Layer Chromatography with Densitometry

Journal of AOAC International ◽

10.1093/jaoac/93.3.778 ◽

2010 ◽

Vol 93 (3) ◽

pp. 778-782 ◽

Cited By ~ 4

Author(s):

Tatána Gondová ◽

Iveta Petríková

Keyword(s):

Thin Layer ◽

Stationary Phase ◽

Thin Layer Chromatography ◽

Mobile Phase ◽

Pharmaceutical Formulations ◽

Simultaneous Separation ◽

Tlc Plates ◽

Precision And Accuracy ◽

Layer Chromatography

Abstract A new and simple TLC-densitometry method has been developed for the simultaneous separation of the two noradrenergic and specific serotonergic antidepressants mirtazapine and mianserine and validated for their determination in commercially available tablets. The method used TLC plates precoated with silica gel 60F254 as the stationary phase, and the mobile phase consisted of hexaneisopropanol25 ammonia (70 + 25 + 5, v/v/v). Densitometric analysis was carried out in the absorbance mode at 280 nm. The method was validated in accordance with International Conference on Harmonization guidelines in terms of linearity, LOD, LOQ, precision, and accuracy. Calibration curves were linear (R2 > 0.9970) with respect to peak area in the concentration range of 5002500 and 5005000 ng/spot for mirtazapine and mianserine, respectively. The LODs were 20 and 35 ng/spot for mirtazapine and mianserine, respectively. The described method was successfully applied to the determination of mirtazapine and mianserine in their pharmaceutical formulations with recovery ranging from 99.83 to 101.20 of the labeled amount of the compounds. The proposed method can be used in routine QC of these drugs in pharmaceutical formulations.

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