Calcium-Sensing Receptor Gene Polymorphism A986S Does Not Predict Serum Calcium Level, Bone Mineral Density, Calcaneal Ultrasound Indices, or Fracture Rate in a Large Cohort of Elderly Women

2003 ◽  
Vol 74 (1) ◽  
pp. 12-17 ◽  
Author(s):  
J. Bollerslev ◽  
S. G. Wilson ◽  
I. M. Dick ◽  
A. Devine ◽  
S. S. Dhaliwal ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Serum Calcium Level ◽  
Elderly Women ◽  
Receptor Gene ◽  
Fracture Rate ◽  
Mineral Density ◽  
Calcium Sensing Receptor ◽  
Calcium Sensing ◽  
Receptor Gene Polymorphism ◽  
Calcium Sensing Receptor Gene

scholarly journals The Calcium-Sensing Receptor Gene Polymorphism rs1801725 and Calcium-Related Phenotypes in Hemodialysis Patients

2018 ◽  
Vol 43 (3) ◽  
pp. 719-734 ◽  
Author(s):  
Alicja E. Grzegorzewska ◽  
Dariusz Bednarski ◽  
Monika Świderska ◽  
Adrianna Mostowska ◽  
Paweł P. Jagodziński
Keyword(s):  
Gene Polymorphism ◽  
Receptor Gene ◽  
Hemodialysis Patients ◽  
Calcium Sensing Receptor ◽  
Calcium Sensing ◽  
Receptor Gene Polymorphism ◽  
Calcium Sensing Receptor Gene

scholarly journals Calcium-sensing receptor gene polymorphism is not associated with bone mineral density in Italian postmenopausal women

2003 ◽  
pp. 603-607 ◽  
Author(s):  
F Cetani ◽  
E Pardi ◽  
S Borsari ◽  
E Vignali ◽  
G Dipollina ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Receptor Gene ◽  
Osteoporotic Fractures ◽  
Fragility Fractures ◽  
Mineral Density ◽  
Calcium Sensing Receptor ◽  
Calcium Sensing ◽  
Significant Difference

OBJECTIVE: Calcium-sensing receptor (CaR) is a candidate gene for osteoporosis susceptibility. Several CaR polymorphisms have been identified and an association between the A986S genotype and serum calcium levels has been found in Canadian postmenopausal women. We investigated whether the presence of 986S allele was associated with bone mineral density (BMD) and osteoporotic fractures. DESIGN: The study group consisted of 164 Italian postmenopausal women without fragility fracture (Fx(-)) and 55 women with fracture (Fx(+)). METHODS: A fragment of exon 7 of CaR gene containing three polymorphisms (A986S, R990G and Q1011E) was amplified by PCR and sequenced. Anthropometric characteristics and BMD were evaluated. RESULTS: The A986S polymorphism was the most commonly observed (27.9%), whereas the other two CaR polymorphisms, R990G and Q1011E, occurred in a minority of cases (8.8 and 5.5% respectively). There was no significant difference in the frequency distribution of any CaR allele between Fx(-) and Fx(+) patients. Body mass index was found to predict BMD at the lumbar spine and femoral neck. The A986S polymorphism and Years since menopause were not independent predictors of BMD at any site. As far as fracture occurrence, there was no statistically significant difference in the prevalence of fractures between women carrying or not carrying the 986S allele. CONCLUSIONS: Our data do not support a role of A986S CaR polymorphism in BMD and in the prevalence of fragility fractures in Italian postmenopausal women.

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