Detecting Novel Bone Density and Bone Size Quantitative Trait Loci Using a Cross of MRL/MpJ and CAST/EiJ Inbred Mice

2007 ◽  
Vol 80 (2) ◽  
pp. 103-110 ◽  
Author(s):  
H. Yu ◽  
S. Mohan ◽  
B. Edderkaoui ◽  
G. L. Masinde ◽  
H. M. Davidson ◽  
...  
Keyword(s):  
Quantitative Trait Loci ◽  
Bone Density ◽  
Quantitative Trait ◽  
Inbred Mice ◽  
Bone Size ◽  
Trait Loci

scholarly journals Quantitative trait loci that determine plasma lipids and obesity in C57BL/6J and 129S1/SvImJ inbred mice

2004 ◽  
Vol 45 (9) ◽  
pp. 1624-1632 ◽  
Author(s):  
Naoki Ishimori ◽  
Renhua Li ◽  
Peter M. Kelmenson ◽  
Ron Korstanje ◽  
Kenneth A. Walsh ◽  
...  
Keyword(s):  
Quantitative Trait Loci ◽  
Quantitative Trait ◽  
Plasma Lipids ◽  
Inbred Mice ◽  
Trait Loci

scholarly journals A genomewide scan for quantitative trait loci underlying areal bone size variation in 451 Caucasian families

2006 ◽  
Vol 43 (11) ◽  
pp. 873-880 ◽  
Author(s):  
H Shen ◽  
J-R Long ◽  
D-H Xiong ◽  
Y-F Guo ◽  
P Xiao ◽  
...  
Keyword(s):  
Quantitative Trait Loci ◽  
Quantitative Trait ◽  
Size Variation ◽  
Bone Size ◽  
Trait Loci

Quantitative Trait Loci Controlling Allergen-Induced Airway Hyperresponsiveness in Inbred Mice

2000 ◽  
Vol 23 (4) ◽  
pp. 537-545 ◽  
Author(s):  
Susan L. Ewart ◽  
Douglas Kuperman ◽  
Eric Schadt ◽  
Clarke Tankersley ◽  
Andrew Grupe ◽  
...  
Keyword(s):  
Quantitative Trait Loci ◽  
Quantitative Trait ◽  
Airway Hyperresponsiveness ◽  
Inbred Mice ◽  
Trait Loci

scholarly journals Quantitative Trait Loci That Determine BMD in C57BL/6J and 129S1/SvImJ Inbred Mice

2005 ◽  
Vol 21 (1) ◽  
pp. 105-112 ◽  
Author(s):  
Naoki Ishimori ◽  
Renhua Li ◽  
Kenneth A Walsh ◽  
Ron Korstanje ◽  
Jarod A Rollins ◽  
...  
Keyword(s):  
Quantitative Trait Loci ◽  
Quantitative Trait ◽  
Inbred Mice ◽  
Trait Loci

scholarly journals Identification of Quantitative Trait Loci That Determine Plasma Total-Cholesterol and Triglyceride Concentrations in DDD/Sgn and C57BL/6J Inbred Mice

Cholesterol ◽  
2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Jun-ichi Suto ◽  
Misaki Kojima
Keyword(s):  
Quantitative Trait Loci ◽  
Total Cholesterol ◽  
Quantitative Trait ◽  
Inbred Mice ◽  
Plasma Lipid ◽  
Interval Mapping ◽  
Plasma Total Cholesterol ◽  
Phenotypic Effect ◽  
Trait Loci ◽  
Genetic Mechanisms

DDD/Sgn mice have significantly higher plasma lipid concentrations than C57BL/6J mice. In the present study, we performed quantitative trait loci (QTL) mapping for plasma total-cholesterol (CHO) and triglyceride (TG) concentrations in reciprocal F2 male intercross populations between the two strains. By single-QTL scans, we identified four significant QTL on chromosomes (Chrs) 1, 5, 17, and 19 for CHO and two significant QTL on Chrs 1 and 12 for TG. By including cross direction as an interactive covariate, we identified separate significant QTL on Chr 17 for CHO but none for TG. When the large phenotypic effect of QTL on Chr 1 was controlled by composite interval mapping, we identified three additional significant QTL on Chrs 3, 4, and 9 for CHO but none for TG. QTL on Chr 19 was a novel QTL for CHO and the allelic effect of this QTL significantly differed between males and females. Whole-exome sequence analysis in DDD/Sgn mice suggested that Apoa2 and Acads were the plausible candidate genes underlying CHO QTL on Chrs 1 and 5, respectively. Thus, we identified a multifactorial basis for plasma lipid concentrations in male mice. These findings will provide insight into the genetic mechanisms of plasma lipid metabolism.

Genetic Effects on Bone Mechanotransduction in Congenic Mice Harboring Bone Size and Strength Quantitative Trait Loci

2007 ◽  
Vol 22 (7) ◽  
pp. 984-991 ◽  
Author(s):  
Alexander G Robling ◽  
Stuart J Warden ◽  
Kathryn L Shultz ◽  
Wesley G Beamer ◽  
Charles H Turner
Keyword(s):  
Quantitative Trait Loci ◽  
Quantitative Trait ◽  
Genetic Effects ◽  
Bone Size ◽  
Congenic Mice ◽  
Trait Loci
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