The Effect of Cyclosporine A on Proteins Controlling Intracellular Calcium Concentration in Breast Cancer Cells

2021 ◽  
Author(s):  
Armagan Caner ◽  
Muge Gulcihan Onal ◽  
Nazmiye Bitgen ◽  
Gulay Sezer
Keyword(s):  
Breast Cancer ◽  
Intracellular Calcium ◽  
Cancer Cells ◽  
Cyclosporine A ◽  
Breast Cancer Cells ◽  
Calcium Concentration ◽  
Intracellular Calcium Concentration

scholarly journals Mango Fruit Extracts Differentially Affect Proliferation and Intracellular Calcium Signalling in MCF-7 Human Breast Cancer Cells

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Meng-Wong Taing ◽  
Jean-Thomas Pierson ◽  
Paul N. Shaw ◽  
Ralf G. Dietzgen ◽  
Sarah J. Roberts-Thomson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Proliferation ◽  
Intracellular Calcium ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Cultivar Differences ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Mcf 7

The assessment of human cancer cell proliferation is a common approach in identifying plant extracts that have potential bioactive effects. In this study, we tested the hypothesis that methanolic extracts of peel and flesh from three archetypal mango cultivars, Irwin (IW), Nam Doc Mai (NDM), and Kensington Pride (KP), differentially affect proliferation, extracellular signal-regulated kinase (ERK) activity, and intracellular calcium ([Ca2+]I) signalling in MCF-7 human breast cancer cells. Mango flesh extracts from all three cultivars did not inhibit cell growth, and of the peel extracts only NDM reduced MCF-7 cell proliferation. Mango cultivar peel and flesh extracts did not significantly change ERK phosphorylation compared to controls; however, some reduced relative maximal peak[Ca2+]Iafter adenosine triphosphate stimulation, with NDM peel extract having the greatest effect among the treatments. Our results identify mango interfruit and intrafruit (peel and flesh) extract variability in antiproliferative effects and[Ca2+]Isignalling in MCF-7 breast cancer cells and highlight that parts of the fruit (such as peel and flesh) and cultivar differences are important factors to consider when assessing potential chemopreventive bioactive compounds in plants extracts.

Regulation of Intracellular Calcium in Human Breast Cancer Cells

Endocrine ◽  
1998 ◽  
Vol 9 (3) ◽  
pp. 321-328 ◽  
Author(s):  
Igor N. Sergeev ◽  
William B. Rhoten
Keyword(s):  
Breast Cancer ◽  
Intracellular Calcium ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast
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