Disrupted resting-state interhemispheric functional connectivity in systemic lupus erythematosus patients with and without neuropsychiatric lupus

2021 ◽  
Author(s):  
Yi-ling Wang ◽  
Mu-liang Jiang ◽  
Li-Xuan Huang ◽  
Xia Meng ◽  
Shu Li ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Functional Connectivity ◽  
Lupus Erythematosus ◽  
Resting State ◽  
Neuropsychiatric Lupus ◽  
Systemic Lupus

Functional Connectivity Changes in Systemic Lupus Erythematosus: A Resting-State Study

2018 ◽  
Vol 8 (4) ◽  
pp. 220-234 ◽  
Author(s):  
Jessika Nystedt ◽  
Peter Mannfolk ◽  
Andreas Jönsen ◽  
Anders Bengtsson ◽  
Petra Nilsson ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Functional Connectivity ◽  
Lupus Erythematosus ◽  
Resting State ◽  
Systemic Lupus ◽  
State Study

scholarly journals Jaw Dystonia and Reversible Basal Ganglia Changes as an Initial Presentation of Systemic Lupus Erythematosus

2017 ◽  
Vol 8 (1) ◽  
pp. 31-34 ◽  
Author(s):  
Meghan Romba ◽  
Yujie Wang ◽  
Shu-Ching Hu ◽  
Sandeep Khot
Keyword(s):  
Systemic Lupus Erythematosus ◽  
White Matter ◽  
Basal Ganglia ◽  
Brain Imaging ◽  
Lupus Erythematosus ◽  
Subcortical White Matter ◽  
High Dose ◽  
Neuropsychiatric Lupus ◽  
Systemic Lupus ◽  
Traditional Treatment

Dystonia as a manifestation of neuropsychiatric lupus erythematosus (NPSLE) is uncommon. We report a 25-year-old woman who experienced progressive confusion, reduced speech, and difficulty opening her mouth approximately 2 weeks after development of a facial rash. Brain imaging showed bilateral, symmetric signal abnormalities within the basal ganglia and subcortical white matter. Despite treatment with high-dose steroids, she continued to have difficulty speaking with evidence of jaw dystonia on examination. Jaw dystonia rapidly improved with the initiation of levodopa. Repeat evaluation 3 months later exhibited the absence of jaw dystonia and near resolution of the imaging abnormalities. Our patient demonstrated a unique presentation with jaw dystonia refractory to traditional treatment for NPSLE. Such a presentation likely represents a severe variant of NPSLE requiring both immunosuppressive and symptomatic therapies.

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