The Effect of Recombinant Human Growth Hormone Therapy on Left-Ventricular Chamber Size and Function in Children With Growth Hormone Deficiency

1. In adult humans with growth hormone deficiency, treatment with growth hormone has recently been shown to have major anabolic effects and to improve exercise performance. The cardiovascular effects of growth hormone in adults with growth hormone deficiency were examined in 24 patients treated with recombinant human growth hormone (0.07 units/kg at night) in a double-blind, placebo-controlled trial lasting 6 months. 2. Compared with placebo, resting M-mode echocardiography showed increases in left ventricular end-diastolic dimension and stroke volume in the group treated with recombinant human growth hormone. No differences were noted between the groups with respect to left ventricular end-systolic dimension, fractional shortening, wall thicknesses or mean arterial blood pressure. Left ventricular myocardial mass increased in the group given recombinant human growth hormone. 3. The supine plasma renin activity was increased and remained elevated over the 6 months, whereas the plasma aldosterone concentration was unchanged, after treatment with recombinant human growth hormone. Clinical signs of sodium retention were evident during the first 3 months of treatment with recombinant human growth hormone. 4. We conclude that treatment with recombinant human growth hormone in adults with growth hormone deficiency resulted in small increases in left ventricular pre-load, due to the sodium-retaining action of growth hormone. Activation of the renin-aldosterone system was involved in such changes. Myocardial hypertrophy was observed without changes in mean arterial pressure, reflecting the anabolic action of growth hormone.

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Effects of two different regimens of recombinant human growth hormone therapy on the bone mineral density of patients with growth hormone deficiency

The Journal of Pediatrics ◽

10.1016/s0022-3476(05)82069-4 ◽

1991 ◽

Vol 119 (3) ◽

pp. 483-485 ◽

Cited By ~ 44

Author(s):

Giorgio Zamboni ◽

Franco Antoniazzi ◽

Giorgio Radetti ◽

Claudia Musumeci ◽

Luciano Tatò

Keyword(s):

Bone Mineral Density ◽

Growth Hormone ◽

Hormone Therapy ◽

Growth Hormone Deficiency ◽

Bone Mineral ◽

Growth Hormone Therapy ◽

Recombinant Human Growth Hormone ◽

Human Growth ◽

Hormone Deficiency ◽

Mineral Density

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Long-term response to recombinant human growth hormone therapy in Indian children with growth hormone deficiency

Indian Journal of Endocrinology and Metabolism ◽

10.4103/ijem.ijem_300_19 ◽

2019 ◽

Vol 23 (4) ◽

pp. 446

Author(s):

Rajesh Khadgawat ◽

Monita Gahlot ◽

Alpesh Goyal ◽

ArunK C. Singh ◽

VivekaP Jyotsna ◽

...

Keyword(s):

Growth Hormone ◽

Hormone Therapy ◽

Growth Hormone Deficiency ◽

Growth Hormone Therapy ◽

Recombinant Human Growth Hormone ◽

Human Growth ◽

Hormone Deficiency ◽

Indian Children ◽

Term Response

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CT-Determined Body Composition Changes with Recombinant Human Growth Hormone Treatment to Adults with Growth Hormone Deficiency

Human Body Composition ◽

10.1007/978-1-4899-1268-8_53 ◽

1993 ◽

pp. 229-231 ◽

Cited By ~ 1

Author(s):

Lars Lönn ◽

Henry Kvist ◽

Ulla Grangård ◽

Bengt-Åke Bengtsson ◽

Lars Sjöström

Keyword(s):

Growth Hormone ◽

Body Composition ◽

Growth Hormone Deficiency ◽

Human Growth Hormone ◽

Growth Hormone Treatment ◽

Recombinant Human Growth Hormone ◽

Human Growth ◽

Hormone Treatment ◽

Hormone Deficiency ◽

Composition Changes

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The Angle of Trunk Rotation in Children With Growth Hormone Deficiency

10.21203/rs.3.rs-70130/v1 ◽

2020 ◽

Author(s):

Magdalena Kobylińska ◽

Roksana Ewa Malak ◽

Katarzyna Majewska ◽

Włodzimierz Samborski ◽

Andrzej Kędzia

Keyword(s):

Growth Hormone ◽

Growth Hormone Deficiency ◽

Human Growth Hormone ◽

Bone Structure ◽

Recombinant Human Growth Hormone ◽

Human Growth ◽

Hormone Deficiency ◽

Trunk Rotation ◽

Sport Activities ◽

Rhgh Treatment

Abstract Background. Growth hormone plays a vital role in the human body. Its deficiency can lead to numerous disorders, including musculoskeletal system defects. Treatment with recombinant human growth hormone (rhGH) in children suffering from growth hormone deficiency (GHD) increases muscle mass and improves bone structure.Aim. The purpose of this study was to evaluate the angle of trunk rotation (ATR) in patients diagnosed with GHD treated with rhGH and to observe the incidence of scoliosis.Material and Methods. The study was conducted among 50 children diagnosed with GHD. The group consisted of 11 girls and 39 boys aged 6-16. The study group included 50 children: 10 children just qualified for rhGH treatment and 40 patients undergoing this treatment, with different therapy duration. ATR was measured using a Bunnell scoliometer on five levels of the spine: cervical 7 / thoracic 1, thoracic 6, thoracic 12 / lumbar 1, lumbar 3, lumbar 5 / sacral 1.Results. The most numerous asymmetries among the examined group were in the thoracolumbar segment and at the thoracic 6 level. Girls had greater asymmetries compared to boys especially at thoraco – lumbar and lumbar 3 level. There were no statistically significant differences in ATR at any level comparing patients before hormonal treatment and patients undergoing rhGH treatment. The age of the beginning of the therapy, the duration of rhGH therapy, and body mass index (BMI) also had no effect on ATR. Sport activities had a positive impact on the results obtained by scoliometer assessment.Conclusions. The angle of trunk rotation is higher in growth hormone-deficient females than in males. Weight, height, BMI, the time of growth hormone therapy beginning and the duration of this therapy do not influence ATR. The more sport activities, the lower value of the angle of trunk rotation, especially in male patients. Obtained results support the thesis, that treatment with recombinant human growth hormone does not increase the incidence of scoliosis.

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