Association of TGFBR2 rs6785358 Polymorphism with Increased Risk of Congenital Ventricular Septal Defect in a Chinese Population

AbstractBackgroundIL-27, a member of the IL-12 family, has been involved in maternal tolerance to the foetus and successful pregnancy. Growing evidences indicate that IL-27 plays a crucial role in pregnancy.AimWe carried out the present study in order to investigate whether polymorphisms in theIL27are associated with the risk for CHDs, including atrial septal defect and ventricular septal defect.Patients and methodsWe conducted this case–control study among 247 atrial septal defect patients, 150 ventricular septal defect patients, and 368 healthy controls in a Chinese population using polymerase chain reaction-restriction fragment length polymorphism assay.ResultsSignificantly increased risk for atrial septal defect (p=0.001, OR=1.490, 95% CI=1.178–1.887) and ventricular septal defect (p=0.004, OR=1.502, 95% CI=1.139–1.976) was observed to be associated with the allele G of rs153109. In a dominant model, we have also observed that increased susceptibilities for atrial septal defect (p<0.01, OR=1.89, 95% CI=1.35–2.63) and ventricular septal defect (p<0.01, OR=2.50, 95% CI=1.67–3.85) were statistically associated with rs153109; however, no association was found between CHD risk and rs17855750 in theIL27gene.ConclusionThe 153109 of theIL27gene may be associated with the susceptibility to CHD, including atrial septal defect and ventricular septal defect.

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Clinical and electrocardiographic variables associated with increased risk of ventricular septal defect in acute anterior myocardial infarction

The American Journal of Cardiology ◽

10.1016/s0002-9149(00)01101-2 ◽

2000 ◽

Vol 86 (8) ◽

pp. 830-834 ◽

Cited By ~ 18

Author(s):

Yochai Birnbaum ◽

Galen S Wagner ◽

Kathy B Gates ◽

Trevor D Thompson ◽

Gabriel I Barbash ◽

...

Keyword(s):

Myocardial Infarction ◽

Ventricular Septal Defect ◽

Septal Defect ◽

Anterior Myocardial Infarction ◽

Increased Risk

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Ondansetron use in the first trimester of pregnancy and the risk of neonatal ventricular septal defect

International Journal of Epidemiology ◽

10.1093/ije/dyz255 ◽

2019 ◽

Vol 49 (2) ◽

pp. 648-656 ◽

Cited By ~ 2

Author(s):

Lara S Lemon ◽

Lisa M Bodnar ◽

William Garrard ◽

Raman Venkataramanan ◽

Robert W Platt ◽

...

Keyword(s):

Ventricular Septal Defect ◽

Birth Defects ◽

Septal Defect ◽

Dose Range ◽

First Trimester ◽

Sensitivity Analyses ◽

Full Cohort ◽

Adjusted Risk ◽

Adjusted Risk Ratio ◽

Increased Risk

Abstract Background Literature is divided regarding the risk of neonatal ventricular septal defect (VSD) associated with first trimester ondansetron use in pregnancy. Methods We evaluated the risk of VSD associated with first trimester exposure to intravenous or oral ondansetron in 33 677 deliveries at Magee–Womens Hospital in Pittsburgh, PA (2006–2014). Using log-binomial regression, we evaluated the risk: (1) in the full cohort, (2) using propensity score designs with both matching and inverse probability weighting and (3) utilizing clustered trajectory analysis evaluating the role of dose. Sensitivity analyses assessed the association between ondansetron and all recorded birth defects in aggregate. Results A total of 3733 (11%) pregnancies were exposed to ondansetron in the first trimester (dose range: 2.4–1008 mg). Ondansetron was associated with increased risk of VSD with risk ratios ranging from 1.7 [95% confidence interval (CI) 1.0–2.9] to 2.1 (95% CI 1.1–4.0) across methods. Risks correspond to one additional VSD for approximately every 330 pregnancies exposed in the first trimester. The association was dose-dependent with increased risk in women receiving highest cumulative doses compared with lowest doses [adjusted risk ratio: 3.2 (95% CI 1.0–9.9)]. The association between ondansetron and congenital malformations was diluted as the outcome included additional birth defects. Conclusions First trimester ondansetron use is associated with an increased risk of neonatal VSD potentially driven by higher doses. This risk should be viewed in the context of risks attributable to severe untreated nausea and vomiting of pregnancy.

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Surgical management of ventricular septal defect with pulmonary stenosis with idiopathic thrombocytopenic purpura

Bangladesh Medical Research Council Bulletin ◽

10.3329/bmrcb.v36i3.6665 ◽

2011 ◽

Vol 36 (3) ◽

pp. 101-103

Author(s):

Shimu Paul ◽

Jalal Uddin ◽

Niaz Ahmed ◽

Md Sirajul Islam ◽

MH Millat

Keyword(s):

Ventricular Septal Defect ◽

Idiopathic Thrombocytopenic Purpura ◽

Heart Surgery ◽

Septal Defect ◽

Pulmonary Stenosis ◽

Fresh Frozen Plasma ◽

Oral Steroid ◽

Thrombocytopenic Purpura ◽

Methyl Prednisolone ◽

Increased Risk

Patients with idiopathic thrombocytopenic pupura (ITP), when under goes any cardiac surgery face an increased risk of postoperative haemorrhagic complications. A 28 years old female patient with idiopathic thrombocytopenic purpura(ITP) and Ventricular septal defect (VSD) with pulmonary stenosis (PS) was operated. We treated her with oral steroid for three weeks immediately before surgery. During surgery under extracorporeal circulation bleeding was controlled meticulously and she was administered methyl prednisolone, injection hydrocortisone, fresh frozen plasma, platelets and whole blood. Steroid was continued postoperatively for two weeks. She did not suffer from any haemorrhagic complication and her recovery was uneventful. Congenital heart disease with idiopathic thrombocytopenic purpura can be operated for heart surgery if appropriate pre, intra and postoperative measures are taken. DOI: 10.3329/bmrcb.v36i3.6665Bangladesh Med Res Counc Bull 2010; 36: 101-103

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Dental Management of a Patient with Pulmonary Atresia and Ventricular Septal Defect

Frontiers in Dentistry ◽

10.18502/fid.v18i21.6931 ◽

2021 ◽

Author(s):

Ghassem Ansari ◽

Mahsa Mansouri ◽

Leila Eftekhar

Keyword(s):

Ventricular Septal Defect ◽

General Anesthesia ◽

G6pd Deficiency ◽

Septal Defect ◽

Genetic Disorder ◽

Pulmonary Atresia ◽

Bacterial Endocarditis ◽

Single Visit ◽

Dental Management ◽

Increased Risk

Pulmonary atresia with ventricular septal defect (PA/VSD) is one of the congenital heart diseases that results in cyanosis, susceptibility to bacterial endocarditis, and increased risk of complications during general anesthesia. Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common inherited genetic disorder affecting the red blood cells. We aimed to elaborate the potential dental management for patients with this serious condition. This report presents the single-visit dental treatment of a three-year-old female with PA/VSD, G6PD deficiency and rampant caries. The complexity of dental treatments, high incidence of dental caries, lack of cooperation, and the systemic condition limit treatment options to providing service under general anesthesia and hospitalization. Careful monitoring of oxygen saturation during general anesthesia and antibiotic prophylaxis are essential due to the invasive nature of dental treatments. It appears that single-visit dental management under general anesthesia minimizes the risk of treatment of patients at high risk of bacterial endocarditis.

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