Overexpression of the ICL1 gene changes the product ratio of citric acid production by Yarrowia lipolytica

2007 ◽  
Vol 77 (4) ◽  
pp. 861-869 ◽  
Author(s):  
André Förster ◽  
Kordula Jacobs ◽  
Thomas Juretzek ◽  
Stephan Mauersberger ◽  
Gerold Barth
Keyword(s):  
Citric Acid ◽  
Yarrowia Lipolytica ◽  
Acid Production ◽  
Citric Acid Production ◽  
Product Ratio

Aconitase overexpression changes the product ratio of citric acid production by Yarrowia lipolytica

2009 ◽  
Vol 81 (6) ◽  
pp. 1087-1096 ◽  
Author(s):  
Martina Holz ◽  
André Förster ◽  
Stephan Mauersberger ◽  
Gerold Barth
Keyword(s):  
Citric Acid ◽  
Yarrowia Lipolytica ◽  
Acid Production ◽  
Citric Acid Production ◽  
Product Ratio

scholarly journals Experimental Design as a Tool for the Development of Citric Acid Production by Yarrowia lipolytica Using Glycerol as a Feedstock

2013 ◽  
Vol 3 (8) ◽  
Author(s):  
Luana V. da Silva ◽  
Camila B. Tavares ◽  
Roberta dos R. Ribeiro ◽  
Fernando L. P. Pessoa ◽  
Maria Alice Z. Coelho ◽  
...  
Keyword(s):  
Citric Acid ◽  
Experimental Design ◽  
Yarrowia Lipolytica ◽  
Acid Production ◽  
Citric Acid Production

scholarly journals Physiological Characterization of a Novel Wild-Type Yarrowia lipolytica Strain Grown on Glycerol: Effects of Cultivation Conditions and Mode on Polyols and Citric Acid Production

2020 ◽  
Vol 10 (20) ◽  
pp. 7373
Author(s):  
Seraphim Papanikolaou ◽  
Panagiota Diamantopoulou ◽  
Fabrice Blanchard ◽  
Eleni Lambrinea ◽  
Isabelle Chevalot ◽  
...  
Keyword(s):  
Citric Acid ◽  
Yarrowia Lipolytica ◽  
Acid Production ◽  
Unsaturated Fatty Acids ◽  
Citric Acid Production ◽  
Wild Type ◽  
Alcohol Production ◽  
Physiological Characterization ◽  
Batch Bioreactor ◽  
New Yeast

A new yeast wild-type Yarrowia lipolytica isolate presented efficient growth on glycerol. During flask cultures, nitrogen limitation led to the secretion of sugar-alcohols as the major metabolites of the process (mannitol, arabitol and erythritol), whereas insignificant quantities of citrate were synthesized. Although in some instances high initial glycerol concentrations were employed (≈150 g/L), remarkable glycerol assimilation and polyol secretion was observed. Total polyols ≈ 52 g/L (conversion yield on glycerol consumed = 0.43 g/g) was recorded in the flask experiments. The sugar-alcohol production bioprocess was successfully simulated with the aid of a modified Velhlust–Aggelis model that fitted very well with the experimental data, while optimized parameter values seemed to be quite consistent. In bioreactor trials, a noticeable metabolic shift towards citric acid production was observed, while simultaneously insignificant polyol quantities were produced. In fed-batch bioreactor experiments, a total citric acid quantity ≈ 102 g/L was recorded—one of the highest in the literature for wild-type Y. lipolytica strains. This metabolic transition was due to higher oxygen saturation into the medium that occurred in the bioreactor experiments compared with the flasks. Cellular lipids produced in the bioreactor trial contained higher concentrations of unsaturated fatty acids compared with those produced in flasks.

Comparison of citric acid production from glycerol and glucose by different strains of Yarrowia lipolytica

2009 ◽  
Vol 26 (7) ◽  
pp. 1217-1224 ◽  
Author(s):  
Anita Rywińska ◽  
Waldemar Rymowicz ◽  
Barbara Żarowska ◽  
Adam Skrzypiński
Keyword(s):  
Citric Acid ◽  
Yarrowia Lipolytica ◽  
Acid Production ◽  
Citric Acid Production ◽  
Different Strains

Inulin hydrolysis and citric acid production from inulin using the surface-engineered Yarrowia lipolytica displaying inulinase

2010 ◽  
Vol 12 (5) ◽  
pp. 469-476 ◽  
Author(s):  
Xiao-Yan Liu ◽  
Zhe Chi ◽  
Guang-Lei Liu ◽  
Fang Wang ◽  
Catherine Madzak ◽  
...  
Keyword(s):  
Citric Acid ◽  
Yarrowia Lipolytica ◽  
Acid Production ◽  
Citric Acid Production ◽  
Inulin Hydrolysis

Repeated fed-batch fermentation using biosensor online control for citric acid production by Yarrowia lipolytica

2011 ◽  
Vol 153 (3-4) ◽  
pp. 133-137 ◽  
Author(s):  
Lucie Moeller ◽  
Mario Grünberg ◽  
Andreas Zehnsdorf ◽  
Andreas Aurich ◽  
Thomas Bley ◽  
...  
Keyword(s):  
Citric Acid ◽  
Yarrowia Lipolytica ◽  
Acid Production ◽  
Batch Fermentation ◽  
Online Control ◽  
Citric Acid Production ◽  
Fed Batch ◽  
Fed Batch Fermentation
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