Is hyaluronic acid production transcriptionally regulated? A transcriptional repressor gene deletion study in Streptococcus zooepidemicus

2021 ◽  
Author(s):  
Weixia Gao ◽  
Xiaoliang Zhang ◽  
Guangtong Zhang ◽  
Meng Zuo ◽  
Wei Cao ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Acid Production ◽  
Gene Deletion ◽  
Transcriptional Repressor ◽  
Streptococcus Zooepidemicus ◽  
Repressor Gene ◽  
Hyaluronic Acid Production

Culture Conditions Optimization of Hyaluronic Acid Production Based on GP and QPSO Algorithms

2012 ◽  
Vol 424-425 ◽  
pp. 141-145 ◽  
Author(s):  
Hai Xia Long ◽  
Xiu Hong Zhang ◽  
Zhuang Jian Mo
Keyword(s):  
Hyaluronic Acid ◽  
Acid Production ◽  
Particle Swarm Optimization Algorithm ◽  
Data Fitting ◽  
Culture Conditions ◽  
Aeration Rate ◽  
Agitation Speed ◽  
Streptococcus Zooepidemicus ◽  
Swarm Optimization ◽  
Hyaluronic Acid Production

This study aimed to optimize the culture conditions (agitation speed, aeration rate and stirrer number) of hyaluronic acid production by Streptococcus zooepidemicus. Two optimization algorithms were used for comparison: response surface methodology (RSM) and genetic programming coupling Quantum-behaved particle swarm optimization algorithm (GP-QPSO). In GP -QPSO approach, GP is employed to model the microbial HA production and QPSO algorithm is used to find out the optimal culture conditions with the established GP estimator as the objective function. The maximum predicted value of HA production by RSM and GP-QPSO was 5.27 and 5.57 g/l, respectively. Here though both RSM and GP-QPSO approach provided good predictions, yet the proposed GP-QPSO method showed a clear superiority over RSM for both data fitting and optimization capabilities

Sign in / Sign up

Export Citation Format

Share Document