Giant cell tumor complicating Paget disease of long bone

Giant cell tumour (GCT) is histopathologically benign tumor of long bone particularly in distal femur and the proximal tibia. It commonly occurs in adults of age 20-40 years but rare in children. GCT is considered to be locally aggressive tumor and tendency of recurrence is higher even after surgery. The clinical features are nonspecific, the principle symptoms are pain, swelling and limiting adjacent joint movements. Diagnosis is based on the radiographic appearance and histopathological findings .In our case X-ray showed ill defined lytic lesion on proximal fibula with cortical thinning and MRI finding revealed expansile lyticlesion in meta-epiphysis of right fibula 16×16×28mm adjacent to growth plate with fluid level. The sclerotic rim appears hypo intense on T1 & hyper intense on T2. Core needle biopsy showed giant cell tumor on proximal fibula. Considering the risk of recurrence wide local excision was done. Management of GCT of proximal fibula in young patient is critical for preventing recurrence and enhancing functional outcomes by saving adjacent anatomical structure. No evidence of local recurrence and metastasis was found in 24 months of follow up.

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Patient-Specific Finite Element Analysis of Femoral Giant Cell Tumor Reconstructed Using Locking Plate System

ASME 2009 Summer Bioengineering Conference, Parts A and B ◽

10.1115/sbc2009-204566 ◽

2009 ◽

Author(s):

Jihui Li ◽

Felasfa Wodajo

Keyword(s):

Finite Element ◽

Giant Cell Tumor ◽

Giant Cell ◽

Locking Plate ◽

Pathologic Fracture ◽

Cell Tumor ◽

Long Bone ◽

Patient Specific ◽

Element Analysis ◽

Reconstruction Methods

Giant cell tumor (GCT) is a benign bone tumor that usually involves the end of long bone in young adults. GCT is locally aggressive, weakens the bone and can lead to pathologic fracture [1, 2]. Clinically, GCT is removed and the defect is reconstructed with bone cement, sometimes enhanced with intramedullary pins. However, there was no significant biomechanical advantage to using a cement plus pin construct over cement alone; clinical outcomes of both reconstruction methods were controversial [3–5]. While locking plates were recently adopted for GCT reconstruction, no biomechanics analysis has been performed to indicate its advantage over the cement alone or cement plus pin reconstruction. In this study we developed patient specific finite element (FE) models to compare the mechanical strengths of GCT reconstructed using cement alone and cement plus locking plate.

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Giant Cell Tumor of the Larynx

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348949810700819 ◽

1998 ◽

Vol 107 (8) ◽

pp. 729-732 ◽

Cited By ~ 6

Author(s):

Kenneth O. Devaney ◽

Alfio Ferlito ◽

Alessandra Rinaldo

Keyword(s):

Giant Cell Tumor ◽

Giant Cell ◽

Malignant Fibrous Histiocytoma ◽

Fibrous Histiocytoma ◽

Sarcomatoid Carcinoma ◽

Cell Tumor ◽

Long Bone ◽

Giant Cell Tumors ◽

Tentative Diagnosis ◽

True Neoplasm

Among the more uncommon tumors that may sometimes be encountered in the laryngeal region is the recently described giant cell tumor of the larynx. This lesion is a true neoplasm, presumably of the fibrohistiocytic series. Histologically, it closely resembles the more familiar true giant cell tumor of long bone. The laryngeal giant cell tumors appear, to date, to be nonmetastasizing lesions; it is possible that they may recur locally if incompletely excised (although this remains to be demonstrated). In view of the rarity of these tumors, a tentative diagnosis of such a neoplasm should always prompt consideration of other (more frequently encountered) differential diagnostic possibilities, including cytologically malignant giant cell-rich tumors such as malignant fibrous histiocytoma and sarcomatoid carcinoma.

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A histological comparison of the giant cells in the central giant cell granuloma of the jaws and the giant cell tumor of long bone

Journal of Oral Pathology and Medicine ◽

10.1111/j.1600-0714.1974.tb01714.x ◽

1974 ◽

Vol 3 (5) ◽

pp. 217-223 ◽

Cited By ~ 45

Author(s):

B. Abrams ◽

M. Shear

Keyword(s):

Giant Cell Tumor ◽

Giant Cell ◽

Giant Cells ◽

Cell Tumor ◽

Long Bone ◽

Giant Cell Granuloma ◽

Central Giant Cell Granuloma

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Reconstruction and repair, using mini-plate and bone graft for persons living with HIV with giant cell tumor of long bone: retrospective analysis of a single-center experience

AIDS Research and Therapy ◽

10.1186/s12981-021-00406-3 ◽

2021 ◽

Vol 18 (1) ◽

Author(s):

Biao Xu ◽

Rui Ma ◽

Wen-sheng Zhang ◽

Qiang Zhang ◽

Chang-song Zhao ◽

...

Keyword(s):

Bone Graft ◽

Giant Cell Tumor ◽

Retrospective Analysis ◽

Giant Cell ◽

Proximal Tibia ◽

Cell Tumor ◽

Long Bone ◽

Hiv Positive ◽

Joint Function ◽

Mini Plate

Abstract Background To evaluate the effect of reconstruction and repair, using a mini-plate and bone graft for HIV -positive patients with giant cell tumor of long bone. Methods We conducted a retrospective analysis of 12 HIV positive patients with giant cell tumor of long bone. A non-HIV-positive cohort of patients, matched for age, sex, and disease type, was selected as the control group. From June 2012 to August 2020, curettage by ultrasonic scalpel was performed in all patients, combined with min- plate and bone graft treatment. All patients were followed- up for 18 to 60 months. Limb function was evaluated, using the MSTS93 scoring system, and any examples of postoperative recurrence, distant metastasis, complications, MSTS93 score, and fracture prognosis were recorded. Results The mean age of HIV group was 43.5 years. The ratio of men to women was 11: 1. In all cases the histopathological diagnosis was clear, except the patients with primary malignant giant cell tumor of bone, including five, three, two, and two cases in the proximal tibia, distal femur, distal tibia, and talus, respectively. Following their surgery, all patients were followed up with an average of 31.24 ± 11.84 months. No local recurrence or pulmonary metastases were observed. Post-surgery, all the 12 patients showed good bone morphologic repair and reconstruction, good bone healing, good joint function, and no pathological fractures around their lesion. In the HIV group, one case of giant cell tumor in the proximal tibia showed mild articular surface collapse and mild valgus deformity of the knee joint but retained good joint function. The MSTS scores of excellent or good in the two groups comprised 83.3%, thus, there was no significant difference between them (P > 0.05). Compared with preoperatively, the MSTS scores in the HIV group were significantly improved, ranging from 7 to 11 points preoperatively to 24 to 27 points postoperatively; this difference was statistically significant (P < 0.05). Conclusion Reconstruction and repair, using a mini-plate and bone graft for HIV -positive patients with giant cell tumor of long bone can achieve satisfactory results. The mini- plate requires little space and is flexible during reconstruction and fixation, significantly reducing complications such as surgical site infection, as well as preserving joint function and avoiding amputation; therefore, it is a safe and effective treatment method.

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