Coupling of porcine bone blood flow and metabolism in high-turnover bone disease measured by [15O]H2O and [18F]fluoride ion positron emission tomography

2002 ◽  
Vol 29 (7) ◽  
pp. 907-914 ◽  
Author(s):  
Morand Piert ◽  
Hans-Jürgen Machulla ◽  
Michael Jahn ◽  
Anke Stahlschmidt ◽  
Georg A. Becker ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Blood Flow ◽  
Bone Disease ◽  
Emission Tomography ◽  
Fluoride Ion ◽  
Bone Blood Flow ◽  
High Turnover ◽  
Positron Emission ◽  
18F Fluoride

scholarly journals 2019 Roger A. Mann Award Winner: Imaging of Bone Perfusion and Metabolism in Subjects Undergoing Total Ankle Arthroplasty Using 18F-Positron Emission Tomography

2019 ◽  
Vol 4 (4) ◽  
pp. 2473011419S0002
Author(s):  
Jonathan H. Garfinkel ◽  
Jonathan P. Dyke ◽  
Lauren Volpert ◽  
Austin Sanders ◽  
Meghan Newcomer ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Blood Flow ◽  
The Body ◽  
Emission Tomography ◽  
Bone Blood Flow ◽  
Positron Emission ◽  
Ankle Replacement ◽  
Pet Ct ◽  
Significant Difference ◽  
18F Fluoride

Category: Ankle Arthritis Introduction/Purpose: Total ankle replacement (TAR) continues to exhibit a relatively high incidence of complications and need for revision surgery, particularly when compared to knee and hip arthroplasty. One common mode of failure in TAR is talar component subsidence. This may be caused by disruption in the talar blood supply related to the surgical technique. Positron emission tomography (PET) imaging with [18F]-Fluoride has demonstrated utility in evaluating bone perfusion, and PET-CT in particular is useful in the setting of total joint replacement. In this study we aim to quantify changes in talar perfusion before and after TAR with the INBONE II system (Wright Medical Technology, Inc., Memphis, TN) using [18F]-Fluoride PET-CT. It is our hypothesis that perfusion to the talus would decrease after TAR. Methods: Eight subjects (5M/3F) aged 70.4 ± 7.5 years [Range 61-83] were enrolled for 18F-PET/CT imaging prior to and 3 months following TAR. 5–10 mCi of 18F-Fluoride was administered and dynamic acquisition in list mode for 45 minutes was performed on the operative and non-operative ankles simultaneously on a Siemens mCT Biograph scanner. Static acquisition of the whole body was also performed one hour after injection. Regions of interest (ROI’s) were placed on the postoperative CT images in the body of the talus beneath the INBONE II talar component. These regions were manually delineated on the preoperative CT scans, and were drawn to replicate the ROIs placed on the postoperative studies. ROI’s were overlaid on the fused static 18F-PET images and standard uptake values (SUVs) calculated for these regions as well as the whole foot. Changes in SUVs were analyzed using a paired t-tests with a significance level of 0.05. Results: We found no significant difference in bone perfusion in the talus after TAR in our cohort of patients. 18F uptake in the ROI underneath the talar component compared to that measured at baseline prior to surgery was 3.36 +/- 1.44 SUV postoperatively vs. 2.65 ± 1.24 SUV preoperatively, (p=0.33). Similar results were seen in the whole foot: 2.99 +/- 1.22 SUV postoperatively vs. 2.47 ± 0.75 SUV preoperatively (p=0.16). Figure 1 displays preoperative and postoperative uptake in the bone in the area corresponding to the base of the talar component. Although we did not find a significant difference in our initial study, the observed increase in perfusion to the talus after TAR may reach significance with a larger cohort of patients. Conclusion: 18F-PET demonstrates the ability to quantify changes in bone perfusion and metabolism following TAR. Our results suggest that the vascular blood supply to the talus is not disrupted after TAR. Additional pharmacokinetic analysis of the dynamic activity curves will also allow for estimates of bone blood flow and osteoblastic turnover via compartmental modeling. These results may be used to confirm the presence of adequate bone blood flow and vascularity in the body of the talus following total ankle replacement.

Early Detection and Accurate Description of Extent of Metastatic Bone Disease in Breast Cancer With Fluoride Ion and Positron Emission Tomography

1999 ◽  
Vol 17 (8) ◽  
pp. 2381-2381 ◽  
Author(s):  
Holger Schirrmeister ◽  
Albrecht Guhlmann ◽  
Jörg Kotzerke ◽  
Claudia Santjohanser ◽  
Thorsten Kühn ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Positron Emission Tomography ◽  
Bone Marrow ◽  
Bone Metastases ◽  
Bone Disease ◽  
Roc Curve ◽  
Metastatic Bone Disease ◽  
Emission Tomography ◽  
Fluoride Ion ◽  
Positron Emission

PURPOSE: Previous studies have shown that bone metastases are revealed by magnetic resonance imaging (MRI) or bone marrow scintigraphy several months before they are visible by conventional bone scintigraphy (BS). We present a new approach for detecting bone metastases in patients with breast cancer. We compared findings obtained with fluoride ion (F-18) and positron emission tomography (PET) with those obtained with conventional BS. PATIENTS AND METHODS: Thirty-four breast cancer patients were prospectively examined using F-18–PET and conventional BS. F-18–PET and BS were performed within 3 weeks of each other. Metastatic bone disease was previously known to be present in six patients and was suspected (bone pain or increasing levels of tumor markers, Ca2+, alkaline phosphatase) in 28 patients. Both imaging modalities were compared by patient-by-patient analysis and lesion-by-lesion analysis, using a five-point scale for receiver operating characteristic (ROC) curve analysis. A panel of reference methodswas used, including MRI (28 patients), planar x-ray (17 patients), and spiral computed tomography (four patients). RESULTS: With F-18–PET, 64 bone metastases were detected in 17 patients. Only 29 metastases were detected in 11 patients with BS. As a result of F-18–PET imaging, clinical management was changed in four patients (11.7%). For F-18–PET, the area under the ROC curve was 0.99 on a lesion basis (for BS, it was 0.74; P < .05) and 1.00 on a patient basis (for BS, it was 0.82; P < .05). CONCLUSION: F-18–PET demonstrates a very early bone reaction when small bone marrow metastases are present, allowing accurate detection of breast cancer bone metastases. This accurate detection has a significant effect on clinical management, compared with the effect on management brought about by detection with conventional BS.

Evaluation of the incorporation of bone grafts used in maxillofacial surgery with [18F]fluoride ion and dynamic positron emission tomography

1995 ◽  
Vol 22 (10) ◽  
pp. 1133-1140 ◽  
Author(s):  
Georg Berding ◽  
Wolfgang Burchert ◽  
Jörg van den Hoff ◽  
Christoph Pytlik ◽  
Friedrich Wilhelm Neukam ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Maxillofacial Surgery ◽  
Bone Grafts ◽  
Emission Tomography ◽  
Fluoride Ion ◽  
Dynamic Positron Emission Tomography ◽  
Positron Emission ◽  
18F Fluoride

Measurement of absolute bone blood flow by positron emission tomography

1986 ◽  
Vol 15 (3) ◽  
pp. 198-200 ◽  
Author(s):  
Claude Nahmias ◽  
W. Peter Cockshott ◽  
L. W. Belbeck ◽  
E. S. Garnett
Keyword(s):  
Positron Emission Tomography ◽  
Blood Flow ◽  
Emission Tomography ◽  
Bone Blood Flow ◽  
Positron Emission

scholarly journals Bone Histomorphometry and 18F-Sodium Fluoride Positron Emission Tomography Imaging: Comparison Between only Bone Turnover-based and Unified TMV-based Classification of Renal Osteodystrophy

2021 ◽  
Author(s):  
Louise Aaltonen ◽  
Niina Koivuviita ◽  
Marko Seppänen ◽  
Inari S. Burton ◽  
Heikki Kröger ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Bone Turnover ◽  
Bone Disease ◽  
Bone Biopsy ◽  
Emission Tomography ◽  
Adynamic Bone Disease ◽  
High Turnover ◽  
Positron Emission ◽  
Adynamic Bone

AbstractBone biopsy is the gold standard for characterization of renal osteodystrophy (ROD). However, the classification of the subtypes of ROD based on histomorphometric parameters is not unambiguous and the range of normal values for turnover differ in different publications. 18F-Sodium Fluoride positron emission tomography (18F-NaF PET) is a dynamic imaging technique that measures turnover. 18F-NaF PET has previously been shown to correlate with histomorphometric parameters. In this cross-sectional study, 26 patients on dialysis underwent a 18F-NaF PET and a bone biopsy. Bone turnover-based classification was assessed using Malluche’s historical reference values for normal bone turnover. In unified turnover-mineralization-volume (TMV)-based classification, the whole histopathological picture was evaluated and the range for normal turnover was set accordingly. Fluoride activity was measured in the lumbar spine (L1–L4) and at the anterior iliac crest. On the basis of turnover-based classification of ROD, 12% had high turnover and 61% had low turnover bone disease. On the basis of unified TMV-based classification of ROD, 42% had high turnover/hyperparathyroid bone disease and 23% had low turnover/adynamic bone disease. When using unified TMV-based classification of ROD, 18F-NaF PET had an AUC of 0.86 to discriminate hyperparathyroid bone disease from other types of ROD and an AUC of 0.87, for discriminating adynamic bone disease. There was a disproportion between turnover-based classification and unified TMV-based classification. More research is needed to establish normal range of bone turnover in patients with CKD and to establish the role of PET imaging in ROD.

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