Role of 18FDG PET/CT in patients treated with 177Lu-DOTATATE for advanced differentiated neuroendocrine tumours

Abstract Introduction: Conventional radiography remains the “gold standard” technique for bone involvement assessment in patients with multiple myeloma (MM). Newer imaging modalities such as whole-body Magnetic Resonance (MR) and 18FDG-PET/CT have emerged as more sensitive techniques than routine skeletal survey in the detection of bone involvement in the diagnostic and follow up of patients with MM. The advantages and disadvantages of MR and 18FDG-PET/CT are discussed. Patients and methods: We have retrospectively analyzed 12 patients since 2012 to 2014 with multiple myeloma in our institution whose bone involvement was evaluated with MR and 18FDG-PET/CT. Age range: 36-70. Seven patients were female and five were male. Eight cases were treated with an induction regimen containing bortezomib, three cases with chemotherapy with alternating VBCMP/VBAD and one of them with VAD. After induction, ten of them received autologous stem cell transplantation (ASCT), one patient allogeneic stem cell transplantation and one patient no transplantation. Results: All patients presented bone lesions on MR and all of them were also positive at PET/CT. One showed leptomeningeal involvement on RM and PET. Regarding extramedullar disease two patients presented soft tissue masses and in other two cases there was ganglionar involvement, all of them positives by both techniques. Of nine evaluable patients after complete treatment, six of them have a negative PET and three have a low positive SUV value, however eight of them still had persistent residual lesions on MR, what could indicate not stringent complete response. The patient with leptomeningeal involvement had both MR and PET negative result after treatment. Comments and conclusions: Our data suggest that whole-body MR and 18FDG-PET/CT provide valuable complementary information, MR could be superior to assess extent of lesions and PET to monitor disease activity and to detect asymptomatic relapse. The optimal imaging technique for the management of patients with MM is not well defined and our proposal is a multimodality imaging approach according to individualized criteria. References: Caers J et al. The role of positron emission tomography-computed and magnetic resonance imaging in diagnosis and follow-up of multiple myeloma. Haematologica 2014;99(4):629-637. doi:10.3324/haematol.2013.091918. Agarwal A et al. Evolving Role of FDG PET/CT in Multiple Myeloma Imaging and Management. AJR 2013;200:884-890. Dimopoulos D et al. International myeloma working group consensus statement and guidelines regarding the current role of imaging techniques in the diagnosis and monitoring of multiple Myeloma. Leukemia 2009, 1–12. doi:10.1038/leu.2009.89 Disclosures Alegre: Celgene: Membership on an entity's Board of Directors or advisory committees, Research Funding; Jansen: Membership on an entity's Board of Directors or advisory committees, Research Funding.

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Role of 18FDG PET/CT in Breast Cancer

Journal of College of Physicians And Surgeons Pakistan ◽

10.29271/jcpsp.2018.03.177 ◽

2018 ◽

Vol 28 (3) ◽

pp. 177-179

Author(s):

Nosheen Fatima ◽

Maseeh uz Zaman

Keyword(s):

Breast Cancer ◽

18Fdg Pet ◽

Pet Ct

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Detection of unknown primary neuroendocrine tumors (CUP-NET) using 68Ga DOTA-NOC receptor PET/CT

Journal of Clinical Oncology ◽

10.1200/jco.2009.27.15_suppl.4599 ◽

2009 ◽

Vol 27 (15_suppl) ◽

pp. 4599-4599

Author(s):

D. Hörsch ◽

V. Prasad ◽

V. Ambrosini ◽

M. Hommann ◽

S. Fanti ◽

...

Keyword(s):

Neuroendocrine Tumours ◽

Primary Tumour ◽

Unknown Primary ◽

Low Grade ◽

Pet Ct ◽

Pancreatic Net ◽

The Mean ◽

Standardised Uptake Values ◽

F 33

4599 Background: This bi-centric study aimed at determining the role of receptor PET/CT using 68Ga-DOTA-NOC in the detection of undiagnosed primary sites of neuroendocrine tumours (NETs). Methods: Overall 59 patients (M: F 33:26, age 65±9 yr) with documented NET and unknown primary, were enrolled. PET/CT was performed after injection of approximately 100 MBq (46–260 MBq) of 68Ga-DOTA-NOC. The maximum standardised uptake values (SUVmax) were calculated and compared with SUVmax in known pancreatic NET (pNET) and ileum / jejunum / duodenum (SI-NET). The results of PET/CT were also correlated with CT alone. Results: In 35/59 (59%) of patients, 68Ga-DOTA-NOC PET/CT localised the site of the primary: ileum/jejunum (14), pancreas (16), rectum (2), lungs (2) and paraganglioma (1). CT alone (on retrospective analyses) confirmed the findings in 12/59 (20%) patients. The mean SUVmax of identified previously unknown pNET and SI-Net were 18.6 ± 9.8 (range 7.8–34.8) and 9.1± 6.0 (range 4.2–27.8), respectively. SUVmax in patients with previously known pNET and SI-NET were 26.1± 14.5 (range 8.7–42.4) and 11.3±3.7 (range 5.6- 17.9). The SUVmax of the unknown pNET and SI-NET were significantly lower (p< 0.05) as compared to the ones with known primary tumour sites. 19% of the patients had high grade, and 81% low grade NET. In 4/59 patients the primary tumour was subsequently resected (2 pancretic, one ileal and one rectal tumour). Conclusions: Our data indicate that 68Ga- DOTA-NOC PET/CT is highly superior to 111In Octreoscan (17% detection rate for CUP according to literature) and can play a major role in the management of patients with CUP-NET. No significant financial relationships to disclose.

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457 ROLE OF 18FDG PET-CT IN PATIENTS LISTED FOR LIVER TRANSPLANTATION FOR HEPATOCELLULAR CARCINOMA

Journal of Hepatology ◽

10.1016/s0168-8278(09)60459-1 ◽

2009 ◽

Vol 50 ◽

pp. S173

Author(s):

T. Decaens ◽

E. Itti ◽

A. Laurent ◽

A. Luciani ◽

J. Tran Van Nhieu ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Liver Transplantation ◽

18Fdg Pet ◽

Pet Ct

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Incremental Role of 18FDG PET/CT in Assessment of Testicular Viability

Nuclear Medicine and Molecular Imaging ◽

10.1007/s13139-018-0531-z ◽

2018 ◽

Vol 52 (5) ◽

pp. 377-379

Author(s):

Venkata Subramanian Krishnaraju ◽

Dharmender Malik ◽

Rajender Kumar ◽

Giridhar S. Bora ◽

Bhagwant Rai Mittal ◽

...

Keyword(s):

18Fdg Pet ◽

Pet Ct

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Recent applications of nuclear medicine in diagnostics (I part)

Italian Journal of Medicine ◽

10.4081/itjm.2010.84 ◽

2013 ◽

pp. 84-91 ◽

Cited By ~ 2

Author(s):

Giorgio Treglia ◽

Ernesto Cason ◽

Giorgio Fagioli

Keyword(s):

Nuclear Medicine ◽

Neuroendocrine Tumours ◽

High Spatial Resolution ◽

Cellular Level ◽

Ct Imaging ◽

Imaging Systems ◽

Lymph Node Mapping ◽

Pet Ct ◽

Anatomic Information

Introduction: Aim of this review is to describe the recent applications of nuclear medicine techniques in diagnostics, particularly in oncology. Materials and methods: We reviewed scientific literature data searching for the current role of tomographic nuclear medicine techniques (SPECTand PET) in oncology and summarized the main applications of these techniques. Results: Nuclear medicine techniques have a key role in oncology allowing early diagnosis of many tumours, an accurate staging of disease and evalutation of treatment response. Hybrid SPECT/CT and PET/CT imaging systems now provide metabolic and functional information from SPECTor PETcombined with the high spatial resolution and anatomic information of CT. The most frequent applications of SPECT/CT in oncology concern thyroid tumours, neuroendocrine tumours, bone metastases and lymph node mapping. Furthermore the evaluation of many tumours may benefit from PET/CT imaging. Discussion: The recent development of new radiopharmaceuticals and the growth of hybrid tomographic devices, such as SPECT/CT and PET/CT, now permits molecular imaging of biologic processes at the cellular level to improve both the diagnosis and treatment of many tumours.

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