Uptake and tracer kinetics of O-(2-18F-fluoroethyl)-l-tyrosine in meningiomas: preliminary results

2014 ◽  
Vol 42 (3) ◽  
pp. 459-467 ◽  
Author(s):  
Jan F. Cornelius ◽  
Gabriele Stoffels ◽  
Christian Filß ◽  
Norbert Galldiks ◽  
Philipp Slotty ◽  
...  
1995 ◽  
Vol 160-161 ◽  
pp. 465-472 ◽  
Author(s):  
S.C. Polischuk ◽  
R.J. Letcher ◽  
R.J. Norstrom ◽  
M.A. Ramsay

1978 ◽  
Vol 235 (3) ◽  
pp. F254-F264 ◽  
Author(s):  
R. N. Pierson ◽  
D. C. Price ◽  
J. Wang ◽  
R. K. Jain

Bromide and sucrose distributions were measured as functions of time after tracer injection into 14 rat organs that accounted for 93% of body wt, with the goal of evaluating the use of bromide and sucrose as tracers for the extracellular water volume (ECW). The tracers, Na, 82Br, 125I-labeled human serum albumin, [14C]sucrose, and 3H2O, were used to calculate bromide and sucrose content in red cells, plasma, and 13 blood-free organs. Selective concentration of Br- occurs in RBC, stomach, and skin, accounting in part for the discrepancy between the Br- space and the smaller ECW volume as derived from other methods. Sucrose is rapidly metabolized in the rat and its 14C tracer cannot be used for ECW determination in this species. The kinetics of Br- distribution were estimated in rats and in 16 human subjects by measuring plasma disappearance values and specific organ uptakes. A pharmacokinetic compartmental model was derived, containing explicit parameters for blood flow, diffusion constants, and ECW spaces separately for each organ. Precise fitting of experimental bromide data was achieved for the rat; satisfactory fitting was also achieved in man from more limited plasma and biopsy data.


1995 ◽  
Vol 80 (5-6) ◽  
pp. 593-612 ◽  
Author(s):  
Youxue Zhang ◽  
E. M. Stolper ◽  
P. D. Ihinger

2013 ◽  
Author(s):  
Franco Marinozzi ◽  
Fabiano Bini ◽  
Andrea Marinozzi ◽  
Annalisa De Paolis ◽  
Emanuele Habib ◽  
...  

1991 ◽  
Vol 261 (2) ◽  
pp. H319-H326 ◽  
Author(s):  
B. A. Williams ◽  
S. C. Huang ◽  
J. Krivokapich ◽  
D. B. Buxton ◽  
H. R. Schelbert

Radiolabeled monoclonal antibody fragments to myosin, specifically 111In-labeled antimyosin, have been shown to be effective for imaging areas of myocardial infarct. To determine if 111In-labeled antimyosin can be used to assess the extent of necrosis, we compared the tissue retention fraction of 111In-labeled antimyosin with the amount of creatine kinase (CK) released from the isolated, perfused, interventricular rabbit septum after an intervention to induce tissue necrosis. 111In-labeled antimyosin was injected and tissue radioactivity was monitored for a 60-min period under control conditions. Effluent samples were also collected during this period and assayed for CK content. After a period of Ca2+ depletion followed by Ca2+ repletion, 111In-labeled antimyosin was again injected, and washout and CK data were collected. Comparison of the changes in 111In-labeled antimyosin retention fraction from control to intervention with the corresponding increase in CK released during intervention resulted in a correlation coefficient of 0.83. To corroborate the findings of the Ca2+ depletion followed by repletion experiments, further experiments were conducted in which zero-flow ischemia followed by reperfusion was used as a means of introducing necrosis in the septum. The resulting correlation coefficient between CK release and 111In-labeled antimyosin retention fraction was 0.82. The results of these experiments indicate that 111In-labeled antimyosin can be used to quantitatively estimate the extent of necrosis in the rabbit septum, as determined by CK release, and endorse the potential use of tracer kinetics in humans for quantitation of myocardial necrosis in vivo.


2008 ◽  
Vol 49 (8) ◽  
pp. 1238-1244 ◽  
Author(s):  
L. G. Strauss ◽  
D. Koczan ◽  
S. Klippel ◽  
L. Pan ◽  
C. Cheng ◽  
...  

1988 ◽  
Vol 124 (1) ◽  
pp. 105-122 ◽  
Author(s):  
Y. Fares ◽  
J. D. Goeschl ◽  
C. E. Magnuson ◽  
H. W. Scheld ◽  
B. R. Strain

1970 ◽  
Vol 48 (14) ◽  
pp. 2173-2176 ◽  
Author(s):  
D. M. Graham ◽  
J. F. Soltys

Investigation of the kinetics of oxygen inhibition of the thiyl radical catalyzed isomerization of cis-butene-2 has yielded an estimate for the relative rates of oxidation (k7) and decomposition (k3) of the CH3S and olefin adduct radical. At 25 °C, k7/k3 = 7 × 104 l mole−1, and E3 − E7 = 11.8 ± 2.5 kcal. Making use of these results, a new method has been developed for determining relative reactivities of olefins, and some preliminary results have been obtained.


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